دورية أكاديمية
Severe anemia in Malawian children.
| العنوان: | Severe anemia in Malawian children. |
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| المؤلفون: | Calis JC; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi; College of Medicine, University of Malawi, Blantyre, Malawi; Emma Children's Hospital, the Global Child Health Group, Academic Medical Center, Amsterdam, The Netherlands., Phiri KS; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi; College of Medicine, University of Malawi, Blantyre, Malawi., Faragher EB; Liverpool School of Tropical Medicine, Liverpool, United Kingdom., Brabin BJ; Emma Children's Hospital, the Global Child Health Group, Academic Medical Center, Amsterdam, The Netherlands; Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom., Bates I; Liverpool School of Tropical Medicine, Liverpool, United Kingdom., Cuevas LE; Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom., de Haan RJ; Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, Amsterdam, the Netherlands., Phiri AI; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi; College of Medicine, University of Malawi, Blantyre, Malawi., Malange P; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi., Khoka M; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi., Hulshof PJ; Division of Human Nutrition, Wageningen University, Wageningen, the Netherlands., van Lieshout L; Department of Parasitology, Leiden University Medical Center, Leiden, the Netherlands., Beld MG; Department of Medical Microbiology, Laboratory of Clinical Virology., Teo YY; Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom., Rockett KA; Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom., Richardson A; Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom., Kwiatkowski DP; Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom., Molyneux ME; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi; College of Medicine, University of Malawi, Blantyre, Malawi; Liverpool School of Tropical Medicine, Liverpool, United Kingdom., van Hensbroek MB; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi; College of Medicine, University of Malawi, Blantyre, Malawi; Emma Children's Hospital, the Global Child Health Group, Academic Medical Center, Amsterdam, The Netherlands; Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom. |
| المصدر: | Malawi medical journal : the journal of Medical Association of Malawi [Malawi Med J] 2016 Sep; Vol. 28 (3), pp. 99-107. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Published by Montfort Press for the Medical Association of Malawi Country of Publication: Malawi NLM ID: 9500170 Publication Model: Print Cited Medium: Internet ISSN: 1995-7270 (Electronic) Linking ISSN: 19957262 NLM ISO Abbreviation: Malawi Med J Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lilongwe, Malawi : Published by Montfort Press for the Medical Association of Malawi, [1990- |
| مستخلص: | Background: Severe anemia is a major cause of sickness and death in African children, yet the causes of anemia in this population have been inadequately studied. Methods: We conducted a case-control study of 381 preschool children with severe anemia (hemoglobin concentration, <5.0 g per deciliter) and 757 preschool children without severe anemia in urban and rural settings in Malawi. Causal factors previously associated with severe anemia were studied. The data were examined by multivariate analysis and structural equation modeling. Results: Bacteremia (adjusted odds ratio, 5.3; 95% confidence interval [CI], 2.6 to 10.9), malaria (adjusted odds ratio, 2.3; 95% CI, 1.6 to 3.3), hookworm (adjusted odds ratio, 4.8; 95% CI, 2.0 to 11.8), human immunodeficiency virus infection (adjusted odds ratio, 2.0; 95% CI, 1.0 to 3.8), the G6PD -202/-376 genetic disorder (adjusted odds ratio, 2.4; 95% CI, 1.3 to 4.4), vitamin A deficiency (adjusted odds ratio, 2.8; 95% CI, 1.3 to 5.8), and vitamin B Conclusions: There are multiple causes of severe anemia in Malawian preschool children, but folate and iron deficiencies are not prominent among them. Even in the presence of malaria parasites, additional or alternative causes of severe anemia should be considered. |
| التعليقات: | Republished from: N Engl J Med. 2008 Feb 28;358(9):888-99. (PMID: 18305266) |
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| معلومات مُعتمدة: | United Kingdom Wellcome Trust |
| تواريخ الأحداث: | Date Created: 20161130 Date Completed: 20170608 Latest Revision: 20181221 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC5116999 |
| PMID: | 27895843 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1995-7270 |
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