دورية أكاديمية
Serum complement C3 strongly correlates with whole-body insulin sensitivity in rheumatoid arthritis.
| العنوان: | Serum complement C3 strongly correlates with whole-body insulin sensitivity in rheumatoid arthritis. |
|---|---|
| المؤلفون: | Ursini F; Department of Health Sciences, University of Catanzaro 'Magna Graecia', Catanzaro, Italy. francesco.ursini@yahoo.it., D'Angelo S; Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera, Potenza, Italy., Russo E; Department of Health Sciences, University of Catanzaro 'Magna Graecia', Catanzaro, Italy., Arturi F; Department of Health Sciences, University of Catanzaro 'Magna Graecia', Catanzaro, Italy., D'Antona L; Department of Health Sciences, University of Catanzaro 'Magna Graecia', Catanzaro, Italy., Bruno C; Department of Health Sciences, University of Catanzaro 'Magna Graecia', Catanzaro, Italy., Naty S; Department of Health Sciences, University of Catanzaro 'Magna Graecia', Catanzaro, Italy., De Sarro G; Department of Health Sciences, University of Catanzaro 'Magna Graecia', Catanzaro, Italy., Olivieri I; Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera, Potenza, Italy., Grembiale RD; Department of Health Sciences, University of Catanzaro 'Magna Graecia', Catanzaro, Italy. |
| المصدر: | Clinical and experimental rheumatology [Clin Exp Rheumatol] 2017 Jan-Feb; Vol. 35 (1), pp. 18-23. Date of Electronic Publication: 2016 Oct 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Clinical And Experimental Rheumatology S.A.S Country of Publication: Italy NLM ID: 8308521 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0392-856X (Print) Linking ISSN: 0392856X NLM ISO Abbreviation: Clin Exp Rheumatol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Pisa : Clinical And Experimental Rheumatology S.A.S Original Publication: Pisa, Italy : Pacini editore, [1983- |
| مواضيع طبية MeSH: | Arthritis, Rheumatoid/*metabolism , Complement C3/*metabolism , Insulin Resistance/*physiology , Obesity/*metabolism, Aged ; Arthritis, Rheumatoid/blood ; Arthritis, Rheumatoid/complications ; Blood Glucose/metabolism ; Body Mass Index ; Female ; Glucose Tolerance Test ; Humans ; Insulin/blood ; Male ; Middle Aged ; Obesity/blood ; Obesity/complications ; Risk Factors ; Waist Circumference |
| مستخلص: | Objectives: Rheumatoid arthritis (RA) is characterised by an excess of cardiovascular diseases (CVD) risk, attributable to a synergy between under-diagnosed traditional risk factors (i.e. insulin resistance) and inflammatory disease activity. The aim of the present study was to evaluate the correlation between inflammatory measures and insulin sensitivity in RA patients. Methods: Forty non-diabetic RA patients (19 males) were recruited. All patients underwent anthropometric measurements, laboratory evaluation and oral glucose tolerance test (OGTT). Insulin sensitivity index (ISI) was calculated with the equation proposed by Matsuda et al., from dynamic values of glucose and insulin obtained during OGTT. Results: In the univariate analysis, lnISI correlated inversely with age, BMI, waist circumference, sBP, ESR, lnCRP and complement C3, but not with disease duration, dBP or complement C4. In non-obese patients (BMI <30 kg/m2, n=28), only age, BMI, lnCRP and C3 maintained their correlation with lnISI. In a stepwise multiple regression using lnISI as the dependent variable and BMI, age, lnCRP and complement C3 as predictors, only BMI and C3 entered the equation and accounted for 38.2% of the variance in lnISI. In non-obese patients, only C3 entered the regression equation, accounting for 32.2% of the variance in lnISI. Using a ROC curve, we identified the best cut-off for complement C3 of 1.22 g/L that yielded a sensitivity of 67% and a specificity of 79% for classification of insulin resistant patients. Conclusions: In RA patients, complement C3 correlates strongly with insulin sensitivity, in both obese and non-obese individuals. |
| المشرفين على المادة: | 0 (Blood Glucose) 0 (Complement C3) 0 (Insulin) |
| تواريخ الأحداث: | Date Created: 20161203 Date Completed: 20170620 Latest Revision: 20170620 |
| رمز التحديث: | 20240628 |
| PMID: | 27908300 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0392-856X |
|---|