دورية أكاديمية
Inhibition of Dimethylbenz(a)anthracene (DMBA) - Croton Oil-Induced Mouse Skin Tumorigenesis by Gmelina arborea with Potential Anti-Inflammatory Activity.
| العنوان: | Inhibition of Dimethylbenz(a)anthracene (DMBA) - Croton Oil-Induced Mouse Skin Tumorigenesis by Gmelina arborea with Potential Anti-Inflammatory Activity. |
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| المؤلفون: | Lawrence L; Amala Cancer Research Centre (Recognized Centre of the University of Calicut, Kerala), Amala Nagar PO, Thrissur-680555, Kerala, India., Menon S; Amala Cancer Research Centre (Recognized Centre of the University of Calicut, Kerala), Amala Nagar PO, Thrissur-680555, Kerala, India., K DM; Amala Cancer Research Centre (Recognized Centre of the University of Calicut, Kerala), Amala Nagar PO, Thrissur-680555, Kerala, India., Sivaram VP; Amala Cancer Research Centre (Recognized Centre of the University of Calicut, Kerala), Amala Nagar PO, Thrissur-680555, Kerala, India., Padikkala J; Amala Cancer Research Centre (Recognized Centre of the University of Calicut, Kerala), Amala Nagar PO, Thrissur-680555, Kerala, India. |
| المصدر: | Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer [J Environ Pathol Toxicol Oncol] 2016; Vol. 35 (3), pp. 263-272. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Begell House Country of Publication: United States NLM ID: 8501420 Publication Model: Print Cited Medium: Internet ISSN: 2162-6537 (Electronic) Linking ISSN: 07318898 NLM ISO Abbreviation: J Environ Pathol Toxicol Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York, Ny : Begell House Original Publication: [Park Forest, Ill. : Chem-Orbital, c1984- |
| مواضيع طبية MeSH: | 9,10-Dimethyl-1,2-benzanthracene/*toxicity , Carcinogenesis/*drug effects , Lamiaceae/*chemistry , Papilloma/*drug therapy , Plant Extracts/*pharmacology , Plant Extracts/*therapeutic use , Skin Neoplasms/*drug therapy, Animals ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Croton Oil/toxicity ; Male ; Mice ; Papilloma/chemically induced ; Plant Bark/chemistry ; Skin Neoplasms/chemically induced |
| مستخلص: | In traditional Indian medicine, the plant Gmelina arborea Linn. (GA) is described to have the ability to relieve edema. The present study evaluates the anticancer property of GA stem bark against 7,12-dimethylbenz(a) anthracene (DMBA)-croton oil-induced skin tumorigenesis along with the evaluation of anti-inflammatory activity. The observed inhibition of inflammation in carrageenan-induced (41.8%) and formalin-induced (34.07%) models may be due to inhibition of prostaglandins (PGs). Skin papilloma was induced by a single topical application of DMBA (470 nmol/200 µL acetone), followed by repeated application of croton oil (1% in 200 µL acetone). Low-concentration GA (GALC; 5% in 200 µL distilled water) and high-concentration GA (GAHC; 10% in 200 µL distilled water) were applied topically 30 min before croton oil application. The GALC and GAHC groups showed 85.7% and 57.14% tumor incidence, respectively. The number of papillomas per mouse was observed to be significantly (p ≤ 0.01) reduced in the treated groups. The onset of papilloma development was delayed considerably from 6 (control) to 12 wk (GAHC). Thus, results from the study give insights into the anticancer efficacy of Gmelina arborea, which may be due to prevention of inflammation-mediated tumor promotion by inhibiting PGs. |
| المشرفين على المادة: | 0 (Anti-Inflammatory Agents) 0 (Plant Extracts) 57-97-6 (9,10-Dimethyl-1,2-benzanthracene) 8001-28-3 (Croton Oil) |
| تواريخ الأحداث: | Date Created: 20161203 Date Completed: 20170207 Latest Revision: 20170207 |
| رمز التحديث: | 20240513 |
| DOI: | 10.1615/JEnvironPatholToxicolOncol.2016014572 |
| PMID: | 27910781 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2162-6537 |
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| DOI: | 10.1615/JEnvironPatholToxicolOncol.2016014572 |