دورية أكاديمية

Presepsin for the detection of early-onset sepsis in preterm newborns.

التفاصيل البيبلوغرافية
العنوان: Presepsin for the detection of early-onset sepsis in preterm newborns.
المؤلفون: Montaldo P; Department of Neonatal Intensive Care, Monaldi Hospital, Naples, Italy.; Centre for Perinatal Neuroscience, Imperial College London, London, UK., Rosso R; Department of Neonatal Intensive Care, Monaldi Hospital, Naples, Italy., Santantonio A; Department of Neonatal Intensive Care, Monaldi Hospital, Naples, Italy., Chello G; Department of Neonatal Intensive Care, Monaldi Hospital, Naples, Italy., Giliberti P; Department of Neonatal Intensive Care, Monaldi Hospital, Naples, Italy.
المصدر: Pediatric research [Pediatr Res] 2017 Feb; Vol. 81 (2), pp. 329-334. Date of Electronic Publication: 2016 Nov 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 0100714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0447 (Electronic) Linking ISSN: 00313998 NLM ISO Abbreviation: Pediatr Res Subsets: MEDLINE
أسماء مطبوعة: Publication: 2012- : New York : Nature Publishing Group
Original Publication: Basel ; New York : Karger.
مواضيع طبية MeSH: Lipopolysaccharide Receptors/*blood , Peptide Fragments/*blood , Sepsis/*blood , Sepsis/*diagnosis, Age of Onset ; Area Under Curve ; Biomarkers/blood ; C-Reactive Protein/analysis ; Calcitonin/blood ; Case-Control Studies ; Female ; Humans ; Infant, Newborn ; Infant, Premature ; Intensive Care Units, Neonatal ; Intensive Care, Neonatal ; Italy ; Male ; Patient Admission ; Protein Precursors/blood ; Reproducibility of Results ; Sensitivity and Specificity ; Time Factors
مستخلص: Background: Early-onset sepsis (EOS) is responsible for an important fraction of neonatal morbidity and mortality all over the world. The aim of this study was to assess whether presepsin (P-SEP) can be a more accurate biomarker of EOS compared with pro-calcitonin (PCT) and C-reactive protein (CRP).
Study Design: Consecutive preterm neonates (<34 wk gestational age, admitted to Neonatal Intensive Care Unit by 6 h of age and undergoing sepsis evaluation) were recruited as part of a case-matched control study. We determined CRP, PCT and P-SEP at admission, and then at 12, 24, and 48 h of age. Neonates recruited into the study were divided into the EOS group (n = 32) and the uninfected group (n =38) according to their infection screening.
Results: P-SEP values were significantly higher in the EOS group than in the uninfected group at different time intervals. The highest accuracy was achieved by P-SEP at 24 h after birth. The AUC for P-SEP was 0.97. In our sample, P-SEP achieved the best accuracy for prediction of EOS at the cut-off of 788 ng/l with 93% sensitivity and 100% specificity.
Conclusions: This study shows that P-SEP is significantly higher in preterm infants with EOS compared with uninfected infants.
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المشرفين على المادة: 0 (Biomarkers)
0 (Lipopolysaccharide Receptors)
0 (Peptide Fragments)
0 (Protein Precursors)
0 (presepsin protein, human)
9007-12-9 (Calcitonin)
9007-41-4 (C-Reactive Protein)
تواريخ الأحداث: Date Created: 20161208 Date Completed: 20171120 Latest Revision: 20220330
رمز التحديث: 20231215
DOI: 10.1038/pr.2016.217
PMID: 27925621
قاعدة البيانات: MEDLINE
الوصف
تدمد:1530-0447
DOI:10.1038/pr.2016.217