دورية أكاديمية
Calcium and calmodulin changes with ageing in C57BL/6J mice.
| العنوان: | Calcium and calmodulin changes with ageing in C57BL/6J mice. |
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| المؤلفون: | Massie HR; Masonic Medical Research Laboratory, Utica, N.Y., Aiello VR, DeWolfe LK |
| المصدر: | Gerontology [Gerontology] 1989; Vol. 35 (2-3), pp. 100-5. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Karger Country of Publication: Switzerland NLM ID: 7601655 Publication Model: Print Cited Medium: Print ISSN: 0304-324X (Print) Linking ISSN: 0304324X NLM ISO Abbreviation: Gerontology Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, New York, Karger. |
| مواضيع طبية MeSH: | Body Composition*, Aging/*physiology , Calcium/*analysis , Calmodulin/*analysis, Animals ; Brain Chemistry ; Calcium/physiology ; Calmodulin/physiology ; Femur/analysis ; Kidney/analysis ; Liver/analysis ; Lung/analysis ; Male ; Mice ; Mice, Inbred C57BL ; Myocardium/analysis |
| مستخلص: | Male C57BL/6J mice ranging in age from 50 to 1186 days were used to measure total calcium and calmodulin concentrations. The increase in calcium between 0 and 1,000 days of age was 260% for kidney, followed by brain (189%), heart (173.5%), lung (106.5%) and liver (78.5%). Calcium in femur declined by 28.2%. The calmodulin content of liver increased with ageing. Both liver and kidney calmodulin concentrations declined early in life followed by ageing-related increases. Brain, lung and heart calmodulin concentrations did not change significantly with ageing. We conclude that changes in calcium homeostasis are not reflected in calmodulin changes. The loss of calcium in bone is consistent with the occurrence of osteoporosis in ageing C57 mice. |
| المشرفين على المادة: | 0 (Calmodulin) SY7Q814VUP (Calcium) |
| تواريخ الأحداث: | Date Created: 19890101 Date Completed: 19891120 Latest Revision: 20180216 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1159/000213006 |
| PMID: | 2792777 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0304-324X |
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| DOI: | 10.1159/000213006 |