دورية أكاديمية
Phototherapy and Risk of Type 1 Diabetes.
| العنوان: | Phototherapy and Risk of Type 1 Diabetes. |
|---|---|
| المؤلفون: | Newman TB; Departments of Epidemiology and Biostatistics, and newman@epi.ucsf.edu.; Pediatrics, University of California, San Francisco, California.; Division of Research, Kaiser Permanente Northern California, Oakland, California; and., Wickremasinghe AC; Departments of Epidemiology and Biostatistics, and.; Department of Pediatrics, Kaiser Permanente, Santa Clara, California., Walsh EM; Division of Research, Kaiser Permanente Northern California, Oakland, California; and., Grimes BA; Departments of Epidemiology and Biostatistics, and., McCulloch CE; Departments of Epidemiology and Biostatistics, and., Kuzniewicz MW; Pediatrics, University of California, San Francisco, California.; Division of Research, Kaiser Permanente Northern California, Oakland, California; and. |
| المصدر: | Pediatrics [Pediatrics] 2016 Nov; Vol. 138 (5). Date of Electronic Publication: 2016 Oct 19. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Academy of Pediatrics Country of Publication: United States NLM ID: 0376422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-4275 (Electronic) Linking ISSN: 00314005 NLM ISO Abbreviation: Pediatrics Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Elk Grove Village Il : American Academy of Pediatrics Original Publication: Springfield, Ill., Thomas. |
| مواضيع طبية MeSH: | Phototherapy*, Diabetes Mellitus, Type 1/*epidemiology, California/epidemiology ; Child ; Child, Preschool ; Cohort Studies ; Female ; Follow-Up Studies ; Humans ; Hyperbilirubinemia/epidemiology ; Hyperbilirubinemia/therapy ; Incidence ; Infant ; Infant, Newborn ; Jaundice, Neonatal/epidemiology ; Jaundice, Neonatal/therapy ; Male ; Multivariate Analysis ; Racial Groups/statistics & numerical data ; Retrospective Studies |
| مستخلص: | Background and Objective: Increases in both phototherapy use and the incidence of type 1 diabetes mellitus (DM-1) have been reported. One large study has suggested a strong association between them. Our objective was to quantify any association between neonatal phototherapy and DM-1 in a northern California integrated health care system. Methods: This retrospective cohort study included 499 642 children born at ≥35 weeks' gestation in 15 Kaiser Permanente Northern California hospitals from 1995 to 2011 and followed until March 31, 2014. We ascertained phototherapy, bilirubin levels, and other covariates from electronic records. We identified DM-1 cases using a diabetes registry and inpatient and outpatient diagnoses. We used traditional and propensity-adjusted Cox models to quantify associations. Results: Phototherapy use increased from 2.7% in 1995 to 16.0% in 2011. DM-1 was diagnosed in 37 of 39 406 children who had received phototherapy (15.1 per 100 000 person-years; mean follow-up 6.2 years) and 712 of 460 236 who had not (18.8 per 100 000 person-years; mean follow-up 8.2 years). There was no evidence of increasing diabetes incidence. We found no association between phototherapy and DM-1 in either unadjusted analyses (incidence rate ratio 0.81; 95% confidence interval, 0.56 to 1.12) or analyses adjusted for hyperbilirubinemia and other covariates (hazard ratio 1.06; 95% confidence interval, 0.78 to 1.45). DM-1 incidence was most strongly associated with race and ethnicity, with whites at highest risk (25.6 per 100 000) and Asians at lowest risk (8.9 per 100 000). Conclusions: We found no evidence of increased DM-1 risk in children who had received phototherapy. Competing Interests: POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose. (Copyright © 2016 by the American Academy of Pediatrics.) |
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| معلومات مُعتمدة: | R01 HS020618 United States HS AHRQ HHS; UL1 TR000004 United States TR NCATS NIH HHS |
| تواريخ الأحداث: | Date Created: 20161213 Date Completed: 20170622 Latest Revision: 20211204 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC5079076 |
| DOI: | 10.1542/peds.2016-0687 |
| PMID: | 27940766 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1098-4275 |
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| DOI: | 10.1542/peds.2016-0687 |