دورية أكاديمية
أعرض في EDS

Computer quantification of "angle of collapse" on maximum expiratory flow volume curve for diagnosing asthma-COPD overlap syndrome.

التفاصيل البيبلوغرافية
العنوان: Computer quantification of "angle of collapse" on maximum expiratory flow volume curve for diagnosing asthma-COPD overlap syndrome.
المؤلفون: Wang W; Department of Pulmonary Medicine, Qilu Hospital, Shandong University, Jinan, People's Republic of China., Xie M; Department of Pulmonary Medicine, Qilu Hospital, Shandong University, Jinan, People's Republic of China., Dou S; Department of Pulmonary Medicine, Qilu Hospital, Shandong University, Jinan, People's Republic of China., Cui L; Department of Pulmonary Medicine, Qilu Hospital, Shandong University, Jinan, People's Republic of China., Xiao W; Department of Pulmonary Medicine, Qilu Hospital, Shandong University, Jinan, People's Republic of China.
المصدر: International journal of chronic obstructive pulmonary disease [Int J Chron Obstruct Pulmon Dis] 2016 Dec 01; Vol. 11, pp. 3015-3022. Date of Electronic Publication: 2016 Dec 01 (Print Publication: 2016).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: DOVE Medical Press Country of Publication: New Zealand NLM ID: 101273481 Publication Model: eCollection Cited Medium: Internet ISSN: 1178-2005 (Electronic) Linking ISSN: 11769106 NLM ISO Abbreviation: Int J Chron Obstruct Pulmon Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Auckland, N.Z. : DOVE Medical Press,
مواضيع طبية MeSH: Computer Simulation* , Maximal Expiratory Flow-Volume Curves* , Pulmonary Ventilation* , Spirometry*, Asthma/*diagnosis , Lung/*physiopathology , Pulmonary Disease, Chronic Obstructive/*diagnosis , Pulmonary Emphysema/*diagnosis, Aged ; Area Under Curve ; Asthma/diagnostic imaging ; Asthma/physiopathology ; Case-Control Studies ; Cross-Sectional Studies ; Female ; Humans ; Lung/diagnostic imaging ; Male ; Middle Aged ; Multidetector Computed Tomography ; Predictive Value of Tests ; Pulmonary Disease, Chronic Obstructive/diagnostic imaging ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Pulmonary Emphysema/diagnostic imaging ; Pulmonary Emphysema/physiopathology ; ROC Curve ; Syndrome
مستخلص: Background: In a previous study, we demonstrated that asthma patients with signs of emphysema on quantitative computed tomography (CT) fulfill the diagnosis of asthma-COPD overlap syndrome (ACOS). However, quantitative CT measurements of emphysema are not routinely available for patients with chronic airway disease, which limits their application. Spirometry was a widely used examination tool in clinical settings and shows emphysema as a sharp angle in the maximum expiratory flow volume (MEFV) curve, called the "angle of collapse (AC)". The aim of this study was to investigate the value of the AC in the diagnosis of emphysema and ACOS.
Methods: This study included 716 participants: 151 asthma patients, 173 COPD patients, and 392 normal control subjects. All the participants underwent pulmonary function tests. COPD and asthma patients also underwent quantitative CT measurements of emphysema. The AC was measured using computer models based on Matlab software. The value of the AC in the diagnosis of emphysema and ACOS was evaluated using receiver-operating characteristic (ROC) curve analysis.
Results: The AC of COPD patients was significantly lower than that of asthma patients and control subjects. The AC was significantly negatively correlated with emphysema index (EI; r =-0.666, P <0.001), and patients with high EI had a lower AC than those with low EI. The ROC curve analysis showed that the AC had higher diagnostic efficiency for high EI (area under the curve =0.876) than did other spirometry parameters. In asthma patients, using the AC ≤137° as a surrogate criterion for the diagnosis of ACOS, the sensitivity and specificity were 62.5% and 89.1%, respectively.
Conclusion: The AC on the MEFV curve quantified by computer models correlates with the extent of emphysema. The AC may become a surrogate marker for the diagnosis of emphysema and help to diagnose ACOS.
Competing Interests: The authors report no conflicts of interest in this work.
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فهرسة مساهمة: Keywords: COPD; MEFV; airway collapse; asthma; emphysema; overlap
تواريخ الأحداث: Date Created: 20161213 Date Completed: 20170808 Latest Revision: 20220408
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5138020
DOI: 10.2147/COPD.S118415
PMID: 27942211
قاعدة البيانات: MEDLINE
الوصف
تدمد:1178-2005
DOI:10.2147/COPD.S118415