دورية أكاديمية
أعرض في EDS

Three-Dimensional Printing of Bone Extracellular Matrix for Craniofacial Regeneration.

التفاصيل البيبلوغرافية
العنوان: Three-Dimensional Printing of Bone Extracellular Matrix for Craniofacial Regeneration.
المؤلفون: Hung BP; Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore 21231, Maryland, United States; Translational Tissue Engineering Center, The Johns Hopkins University School of Medicine, Baltimore 21231, Maryland, United States., Naved BA; Fischell Department of Biomedical Engineering, University of Maryland, College Park, Maryland 21231, United States., Nyberg EL; Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore 21231, Maryland, United States; Translational Tissue Engineering Center, The Johns Hopkins University School of Medicine, Baltimore 21231, Maryland, United States., Dias M; Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore 21231, Maryland, United States; Translational Tissue Engineering Center, The Johns Hopkins University School of Medicine, Baltimore 21231, Maryland, United States., Holmes CA; Department of Neurosurgery, The Johns Hopkins Hospital, Baltimore 21231, Maryland, United States., Elisseeff JH; Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore 21231, Maryland, United States; Translational Tissue Engineering Center, The Johns Hopkins University School of Medicine, Baltimore 21231, Maryland, United States., Dorafshar AH; Department of Plastic Surgery, The Johns Hopkins Hospital, Baltimore 21231, Maryland, United States., Grayson WL; Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore 21231, Maryland, United States; Translational Tissue Engineering Center, The Johns Hopkins University School of Medicine, Baltimore 21231, Maryland, United States.
المصدر: ACS biomaterials science & engineering [ACS Biomater Sci Eng] 2016 Oct 10; Vol. 2 (10), pp. 1806-1816. Date of Electronic Publication: 2016 Apr 18.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101654670 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2373-9878 (Print) Linking ISSN: 23739878 NLM ISO Abbreviation: ACS Biomater Sci Eng Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : American Chemical Society, [2015]-
مستخلص: Tissue-engineered approaches to regenerate bone in the craniomaxillofacial region utilize biomaterial scaffolds to provide structural and biological cues to stem cells to stimulate osteogenic differentiation. Bioactive scaffolds are typically comprised of natural components but often lack the manufacturability of synthetic materials. To circumvent this trade-off, we 3D printed materials comprised of decellularized bone (DCB) matrix particles combined with polycaprolactone (PCL) to create novel hybrid DCB:PCL scaffolds for bone regeneration. Hybrid scaffolds were readily printable at compositions of up to 70% bone by mass and displayed robust mechanical properties. Assessments of surface features revealed both collagenous and mineral components of bone were present. Qualitative and quantitative assessments showed increased surface roughness relative to that of pure PCL scaffolds. These findings correlated with enhanced cell adhesion on hybrid surfaces relative to that on pure surfaces. Human adipose-derived stem cells (hASCs) cultured in DCB:PCL scaffolds without soluble osteogenic cues exhibited significant upregulation of osteogenic genes in hybrid scaffolds relative to pure PCL scaffolds. In the presence of soluble phosphate, hybrid scaffolds resulted in increased calcification. The hASC-seeded scaffolds were implanted into critical-sized murine calvarial defects and yielded greater bone regeneration in DCB:PCL scaffolds compared to that in PCL-only at 1 and 3 months post-transplantation. Taken together, these results demonstrate that 3D printed DCB:PCL scaffolds might be effective for stimulating bone regeneration.
Competing Interests: Notes The authors declare no competing financial interest.
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معلومات مُعتمدة: F31 DE024922 United States DE NIDCR NIH HHS
فهرسة مساهمة: Keywords: 3D-printing; biomaterials; bone regeneration; decellularized bone; tissue engineering
تواريخ الأحداث: Date Created: 20161213 Latest Revision: 20200929
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5142751
DOI: 10.1021/acsbiomaterials.6b00101
PMID: 27942578
قاعدة البيانات: MEDLINE
الوصف
تدمد:2373-9878
DOI:10.1021/acsbiomaterials.6b00101