دورية أكاديمية
أعرض في EDS

Recommendations for Updating T and N Staging Systems for Nasopharyngeal Carcinoma in the Era of Intensity-Modulated Radiotherapy.

التفاصيل البيبلوغرافية
العنوان: Recommendations for Updating T and N Staging Systems for Nasopharyngeal Carcinoma in the Era of Intensity-Modulated Radiotherapy.
المؤلفون: Liang ZG; Department of Radiation Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, Nanning, P.R. China., Chen XQ; Department of Radiation Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, Nanning, P.R. China., Niu ZJ; Department of Radiation Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, Nanning, P.R. China., Chen KH; Department of Radiation Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, Nanning, P.R. China., Li L; Department of Radiation Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, Nanning, P.R. China., Qu S; Department of Radiation Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, Nanning, P.R. China., Su F; Department of Radiation Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, Nanning, P.R. China., Zhao W; Department of Radiation Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, Nanning, P.R. China., Li Y; Department of Radiation Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, Nanning, P.R. China., Pan XB; Department of Radiation Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, Nanning, P.R. China., Zhu XD; Department of Radiation Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, Nanning, P.R. China.
المصدر: PloS one [PLoS One] 2016 Dec 14; Vol. 11 (12), pp. e0168470. Date of Electronic Publication: 2016 Dec 14 (Print Publication: 2016).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Radiotherapy, Intensity-Modulated*, Carcinoma/*diagnosis , Carcinoma/*radiotherapy , Nasopharyngeal Neoplasms/*diagnosis , Nasopharyngeal Neoplasms/*radiotherapy , Neoplasm Staging/*methods, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biopsy ; China ; Disease-Free Survival ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Nasopharyngeal Carcinoma ; Neoplasm Metastasis ; Neoplasm Recurrence, Local ; Prognosis ; Retrospective Studies ; Societies, Medical ; United States ; Young Adult
مستخلص: Objective: The aim of this study was to compare the 2008 Chinese and the 7th edition of the American Joint Committee on Cancer (AJCC) staging systems for nasopharyngeal carcinoma and to provide proposals for updating T and N staging systems of the present staging system.
Methods: Between January 2007 and December 2012, a cohort of 752 patients with biopsy-proven, newly diagnosed, non-metastatic nasopharyngeal carcinoma who were treated with intensity-modulated radiotherapy were retrospectively analysed. Prognoses were compared by T stage, N stage, and clinical stage according to the two staging systems for overall survival (OS), local relapse-free survival (LRFS), and distant metastasis-free survival (DMFS).
Results: In terms of both the T and N staging systems, the two current staging systems were comparable in predicting OS. The T classification of the 2008 Chinese staging system was better in predicting LRFS, while the N classification of the 7th edition AJCC staging system was superior in predicting DMFS. In the modern era of intensity-modulated radiotherapy, the staging system should be updated by down-staging the current stage T2 to T1, and it might be rational to merge subcategories N1 and N2.
Conclusions: The two current staging systems each had advantages in predicting prognosis. It seems reasonable to downstage T2 to T1 and to merge N1 and N2.
Competing Interests: The authors have declared that no competing interests exist.
References: Int J Radiat Oncol Biol Phys. 2012 Jan 1;82(1):327-33. (PMID: 21035959)
Oral Oncol. 2015 Mar;51(3):254-9. (PMID: 25467207)
Biomed Mater Eng. 2014;24(1):1117-24. (PMID: 24212004)
Oncotarget. 2016 Feb 2;7(5):6221-30. (PMID: 26716900)
Sci Rep. 2016 Mar 01;6:22326. (PMID: 26928265)
Chin J Cancer. 2016 Jan 06;35:2. (PMID: 26739148)
Asian Pac J Cancer Prev. 2013;14(4):2243-8. (PMID: 23725120)
Cancer. 2016 Feb 15;122(4):546-58. (PMID: 26588425)
Medicine (Baltimore). 2015 Sep;94(39):e1457. (PMID: 26426610)
Radiother Oncol. 2012 Sep;104(3):331-7. (PMID: 22103978)
Oncotarget. 2016 Oct 18;7(42):69041-69050. (PMID: 27634892)
Chin J Cancer. 2015 May 20;34(5):189-97. (PMID: 26058563)
BMC Cancer. 2013 May 27;13:260. (PMID: 23710879)
Curr Oncol. 2014 Jun;21(3):e408-17. (PMID: 24940100)
Chin J Cancer. 2014 Oct;33(10 ):511-20. (PMID: 25104280)
CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90. (PMID: 21296855)
Tumour Biol. 2016 Apr;37(4):4429-38. (PMID: 26499947)
Oral Oncol. 2012 Oct;48(10):1007-13. (PMID: 22525607)
J Cancer Res Clin Oncol. 2014 Jan;140(1):69-76. (PMID: 24173695)
Am J Clin Oncol. 2015 Apr;38(2):189-96. (PMID: 23608833)
تواريخ الأحداث: Date Created: 20161216 Date Completed: 20170711 Latest Revision: 20220316
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC5156424
DOI: 10.1371/journal.pone.0168470
PMID: 27973544
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0168470