دورية أكاديمية
أعرض في EDS

Switching of adenosine diphosphate receptor inhibitor after hospital discharge among myocardial infarction patients: Insights from the Treatment with Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events after Acute Coronary Syndrome (TRANSLATE-ACS) observational study.

التفاصيل البيبلوغرافية
العنوان: Switching of adenosine diphosphate receptor inhibitor after hospital discharge among myocardial infarction patients: Insights from the Treatment with Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events after Acute Coronary Syndrome (TRANSLATE-ACS) observational study.
المؤلفون: Zettler ME; Eli Lilly & Company, Indianapolis, IN., Peterson ED; Duke Clinical Research Institute, Durham, NC., McCoy LA; Duke Clinical Research Institute, Durham, NC., Effron MB; Eli Lilly & Company, Indianapolis, IN., Anstrom KJ; Duke Clinical Research Institute, Durham, NC., Henry TD; Cedars-Sinai Medical Center, Los Angeles, CA., Baker BA; Daiichi Sankyo, Inc., Parsippany, NJ., Messenger JC; University of Colorado School of Medicine, Aurora, CO., Cohen DJ; Saint Luke's Mid America Heart Institute, Kansas City, MO., Wang TY; Duke Clinical Research Institute, Durham, NC. Electronic address: tracy.wang@dm.duke.edu.
مؤلفون مشاركون: TRANSLATE-ACS Investigators
المصدر: American heart journal [Am Heart J] 2017 Jan; Vol. 183, pp. 62-68. Date of Electronic Publication: 2016 Oct 15.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Mosby Country of Publication: United States NLM ID: 0370465 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6744 (Electronic) Linking ISSN: 00028703 NLM ISO Abbreviation: Am Heart J Subsets: MEDLINE
أسماء مطبوعة: Original Publication: St. Louis, MO : Mosby
مواضيع طبية MeSH: Drug Substitution/*statistics & numerical data , Myocardial Infarction/*drug therapy , Purinergic P1 Receptor Antagonists/*therapeutic use, Adenosine/analogs & derivatives ; Adenosine/therapeutic use ; Adenosine Diphosphate ; Aged ; Cardiovascular Diseases/epidemiology ; Clopidogrel ; Female ; Hemorrhage/chemically induced ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Patient Discharge ; Patient Preference ; Platelet Aggregation Inhibitors/therapeutic use ; Prasugrel Hydrochloride/therapeutic use ; Purinergic P1 Receptor Antagonists/adverse effects ; Purinergic P1 Receptor Antagonists/economics ; Ticagrelor ; Ticlopidine/analogs & derivatives ; Ticlopidine/therapeutic use
مستخلص: The reasons for postdischarge adenosine diphosphate receptor inhibitor (ADPri) switching among patients with myocardial infarction (MI) are unclear. We sought to describe the incidence and patterns of postdischarge ADPri switching among patients with acute MI treated with percutaneous coronary intervention.
Methods: We used TRANSLATE-ACS (2010-2012) data to assess postdischarge ADPri switching among 8,672 MI patients discharged after percutaneous coronary intervention who remained on ADPri therapy 1 year post-MI. We examined patient-reported reasons for switching, GUSTO moderate or severe bleeding, major adverse cardiovascular events (MACEs), and definite stent thrombosis events around the time of the switch.
Results: Among patients still on ADPri therapy 1 year post-MI, 663 (7.6%) switched ADPri during that year. Switching occurred at a median of 50 days postdischarge and most frequently in patients discharged on ticagrelor (64/226; 28.3%), followed by prasugrel (383/2,489; 15.4%) and clopidogrel (216/5,957; 3.6%) (P < .001). Among patients discharged on prasugrel, 97.3% of switches were to clopidogrel and 87.5% of ticagrelor switches were to clopidogrel; both of these groups most often cited cost as a reason for switching (43.6% and 39.1%, respectively), whereas 60.7% who switched from clopidogrel cited physician decision as a reason. In the 7 days preceding the switch from clopidogrel, 40 (18.5%) had a MACE and 12 (5.6%) had a definite stent thrombosis event, whereas that from prasugrel or ticagrelor, a GUSTO moderate or severe bleeding event occurred in 1 (0.3%) and 0 patients, respectively.
Conclusions: Postdischarge ADPri switching occurred infrequently within the first year post-MI and uncommonly was associated with MACEs or bleeding events.
(Copyright © 2016 Elsevier Inc. All rights reserved.)
المشرفين على المادة: 0 (Platelet Aggregation Inhibitors)
0 (Purinergic P1 Receptor Antagonists)
61D2G4IYVH (Adenosine Diphosphate)
A74586SNO7 (Clopidogrel)
G89JQ59I13 (Prasugrel Hydrochloride)
GLH0314RVC (Ticagrelor)
K72T3FS567 (Adenosine)
OM90ZUW7M1 (Ticlopidine)
تواريخ الأحداث: Date Created: 20161217 Date Completed: 20170525 Latest Revision: 20181202
رمز التحديث: 20221213
DOI: 10.1016/j.ahj.2016.10.006
PMID: 27979043
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-6744
DOI:10.1016/j.ahj.2016.10.006