دورية أكاديمية
أعرض في EDS

Moderate aerobic exercise on the recovery phase of gentamicin-induced acute kidney injury in rats.

التفاصيل البيبلوغرافية
العنوان: Moderate aerobic exercise on the recovery phase of gentamicin-induced acute kidney injury in rats.
المؤلفون: Oliveira CS; Translational Medicine, Universidade Federal de Sao Paulo, UNIFESP-EPM, Brazil., Rodrigues AM; Nephrology, Universidade Federal de Sao Paulo, UNIFESP-EPM, Brazil., Nogueira GB; Nephrology, Universidade Federal de Sao Paulo, UNIFESP-EPM, Brazil., Nascimento MA; Translational Medicine, Universidade Federal de Sao Paulo, UNIFESP-EPM, Brazil., Punaro GR; Nephrology, Universidade Federal de Sao Paulo, UNIFESP-EPM, Brazil., Higa EM; Translational Medicine, Universidade Federal de Sao Paulo, UNIFESP-EPM, Brazil; Nephrology, Universidade Federal de Sao Paulo, UNIFESP-EPM, Brazil; Emergency Division, Universidade Federal de Sao Paulo, UNIFESP-EPM, Brazil. Electronic address: emshiga@unifesp.br.
المصدر: Life sciences [Life Sci] 2017 Jan 15; Vol. 169, pp. 37-42. Date of Electronic Publication: 2016 Oct 29.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE
أسماء مطبوعة: Publication: <2008->: Amsterdam : Elsevier
Original Publication: Oxford; Elmsford, N. Y. [etc.] Pergamon Press.
مواضيع طبية MeSH: Anti-Bacterial Agents* , Gentamicins*, Acute Kidney Injury/*chemically induced , Acute Kidney Injury/*therapy , Exercise Therapy/*methods , Kidney/*physiopathology, Acute Kidney Injury/metabolism ; Acute Kidney Injury/physiopathology ; Animals ; Kidney/drug effects ; Kidney/metabolism ; Kidney Function Tests ; Male ; Oxidative Stress/drug effects ; Physical Conditioning, Animal ; Rats, Wistar
مستخلص: Introduction: Acute kidney injury is a serious public health problem, especially in intensive care units, where patients may require dialysis support, resulting in 50% mortality.
Aim: To evaluate the effects of moderate aerobic exercise on the recovery phase of acute kidney injury induced by gentamicin in rats.
Main Methods: Male adult Wistar rats were allocated into 4 groups: W10+R30, G10+R30, W10+EX30 and G10+EX30; W10 received water (gentamicin vehicle) and G10 received gentamicin for 10days; R30 remained resting and EX30 made exercise for 30days after gentamicin suspension. Training was performed on treadmill. Blood, 24h urine and kidneys were collected for renal function and oxidative stress, antioxidant, TGF-β and histological analysis.
Key Findings: Gentamicin treatment caused decreased renal function significant oxidative stress, reduced urinary nitric oxide and increased TGF-β. G10+R30 presented partial recovery of metabolic data, renal function and lipoperoxidation levels, although they were still altered compared to W10+R30. Besides, we observed the presence of lymphomononuclear infiltrate in the kidneys of G10+R30. G10+EX30 vs G10+R30 showed additional improvement of all the mentioned parameters, showing at histology, regeneration of the tubule epithelium.
Significance: Our data suggest that moderate exercises could help in the recovery of metabolic parameters, renal function and structure on gentamicin-induced AKI, perhaps due to restoration of redox balance. This could protect the kidneys from further insults like challenges with nephrotoxic drugs or the aging per se.
(Copyright © 2016 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Acute kidney injury; Antioxidants; Gentamicin; Nephrotoxicity; Oxidative stress; TGF-β
المشرفين على المادة: 0 (Anti-Bacterial Agents)
0 (Gentamicins)
تواريخ الأحداث: Date Created: 20161217 Date Completed: 20170221 Latest Revision: 20170221
رمز التحديث: 20231215
DOI: 10.1016/j.lfs.2016.10.028
PMID: 27984075
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0631
DOI:10.1016/j.lfs.2016.10.028