دورية أكاديمية
Vitamin C Deficiency, High-Sensitivity C-Reactive Protein, and Cardiac Event-Free Survival in Patients With Heart Failure.
| العنوان: | Vitamin C Deficiency, High-Sensitivity C-Reactive Protein, and Cardiac Event-Free Survival in Patients With Heart Failure. |
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| المؤلفون: | Song EK; Eun Kyeung Song, PhD, RN Associate Professor, Department of Nursing, College of Medicine, University of Ulsan, Korea. Seok-Min Kang, MD, PhD Professor, Division of Cardiology, Yonsei Cardiovascular Center and Cardiovascular Research Institute, Severance Hospital, Seoul, Korea., Kang SM |
| المصدر: | The Journal of cardiovascular nursing [J Cardiovasc Nurs] 2018 Jan/Feb; Vol. 33 (1), pp. 6-12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8703516 Publication Model: Print Cited Medium: Internet ISSN: 1550-5049 (Electronic) Linking ISSN: 08894655 NLM ISO Abbreviation: J Cardiovasc Nurs Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2003- : Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: [Frederick, MD : Aspen Publishers, c1986- |
| مواضيع طبية MeSH: | Ascorbic Acid Deficiency/*blood , Ascorbic Acid Deficiency/*complications , C-Reactive Protein/*metabolism , Heart Failure/*blood , Heart Failure/*mortality, Aged ; Aged, 80 and over ; Ascorbic Acid Deficiency/mortality ; Biomarkers/blood ; Diet ; Disease-Free Survival ; Female ; Heart Failure/complications ; Humans ; Logistic Models ; Male ; Middle Aged ; Nutritional Status ; Proportional Hazards Models ; Prospective Studies |
| مستخلص: | Background: Vitamin C is related to lower levels of high-sensitivity C-reactive protein (hsCRP), an inflammatory biomarker that predicts cardiovascular disease. Whether vitamin C deficiency is associated with hsCRP and cardiac events in heart failure (HF) patients has not been examined. Purpose: The aim of this study is to determine the relationships among vitamin C intake, serum levels of hsCRP, and cardiac events. Methods: A total of 200 HF patients completed a 3-day food diary to determine vitamin C deficiency and provided blood to measure serum levels of hsCRP. Patients were followed for 2 years to obtain data on cardiac event-free survival. Moderation analyses with hierarchical logistic and Cox regressions were used for the data analysis. Results: Seventy-eight patients (39%) had vitamin C deficiency and 100 (50%) had an hsCRP level higher than 3 mg/L. Vitamin C deficiency was associated with an hsCRP level higher than 3 mg/L in the hierarchical logistic regression (odds ratio, 2.40; 95% confidence interval, [1.13-5.10]; P = .023). Vitamin C deficiency (hazard ratio, 1.68; 95% CI, 1.05-2.69, P = .029) and hsCRP level higher than 3 mg/L (hazard ratio, 1.79; 95% CI, 1.07-3.01; P = .027) predicted shorter cardiac event-free survival in hierarchical Cox regression. The interaction of hsCRP level higher than 3 mg/L and vitamin C deficiency produced a 2.3-fold higher risk for cardiac events (P = .002) in moderation analysis. Higher level of hsCRP predicted shorter cardiac event-free survival only in patients with vitamin C deficiency (P = .027), but not in those with vitamin C adequacy. Conclusion: Vitamin C deficiency moderated the relationship between inflammation and cardiac events in patients with HF. Future study is required to determine whether adequate intake of vitamin C could play a protective role against the impact of inflammation on cardiac events in HF patients. |
| المشرفين على المادة: | 0 (Biomarkers) 9007-41-4 (C-Reactive Protein) |
| تواريخ الأحداث: | Date Created: 20161217 Date Completed: 20180810 Latest Revision: 20180810 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1097/JCN.0000000000000389 |
| PMID: | 27984333 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1550-5049 |
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| DOI: | 10.1097/JCN.0000000000000389 |