دورية أكاديمية
Long-Term Morbidity and Quality of Life in Cervical Cancer Survivors: A Multicenter Comparison Between Surgery and Radiotherapy as Primary Treatment.
| العنوان: | Long-Term Morbidity and Quality of Life in Cervical Cancer Survivors: A Multicenter Comparison Between Surgery and Radiotherapy as Primary Treatment. |
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| المؤلفون: | Derks M; Department of Gynaecologic Oncology, Academic Medical Center, Centre for Gynaecological Oncology, Amsterdam; †Department of Gynaecology, ‡Department of Medical Decision Making, Leiden University Medical Center, Leiden; §Department of Radiotherapy and ∥Department of Gynaecology, Academic Medical Center, Amsterdam, the Netherlands., van Lonkhuijzen LR, Bakker RM, Stiggelbout AM, de Kroon CD, Westerveld H, Roovers JP, Kenter GG, Ter Kuile MM |
| المصدر: | International journal of gynecological cancer : official journal of the International Gynecological Cancer Society [Int J Gynecol Cancer] 2017 Feb; Vol. 27 (2), pp. 350-356. |
| نوع المنشور: | Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: BMJ Country of Publication: England NLM ID: 9111626 Publication Model: Print Cited Medium: Internet ISSN: 1525-1438 (Electronic) Linking ISSN: 1048891X NLM ISO Abbreviation: Int J Gynecol Cancer Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2019- : [London] : BMJ Original Publication: Cambridge, MA, USA : Blackwell Scientific Publications, c1991- |
| مواضيع طبية MeSH: | Cancer Survivors*, Uterine Cervical Neoplasms/*radiotherapy , Uterine Cervical Neoplasms/*surgery, Adult ; Aged ; Cross-Sectional Studies ; Female ; Humans ; Hysterectomy ; Lymph Node Excision ; Middle Aged ; Morbidity ; Neoplasm Staging ; Quality of Life ; Self Report ; Uterine Cervical Neoplasms/mortality ; Uterine Cervical Neoplasms/physiopathology |
| مستخلص: | Objective: To compare long-term morbidity and quality of life after primary surgery or primary radiotherapy for stage IB/II cervical cancer. Methods: A cross-sectional study was performed. Patients treated for stage IB/II cervical cancer between 2000 and 2010 were approached to participate. Primary treatment consisted of radical hysterectomy with pelvic lymphadenectomy (RHL), for selected cases followed by adjuvant (chemo-)radiotherapy, or primary (chemo)radiotherapy (PRT). European Organization for Research and Treatment of Cancer-C30 and European Organization for Research and Treatment of Cancer-CX24 questionnaires were administered. A multivariable analysis was performed to identify factors associated with morbidity/quality of life. In a subgroup analysis, we compared patients with RHL + adjuvant radiotherapy with those after PRT. Results: Three hundred twenty-three cervical cancer survivors were included (263 RHL/60 PRT). In the PRT group, International Federation of Gynecology and Obstetrics stage was higher and women were older. In the RHL group, more women had a partner. Women treated with PRT reported lower physical (β, -6.01) and social functioning (β, -15.2), more financial problems (β, 10.9), diarrhea (β, 9.98), symptom experience (β, 6.13), sexual worry (β, 11.3), and worse sexual/vaginal functioning (β, 11.4). Women treated with RHL reported significantly more lymphedema (β, -16.1). No differences in global health were found. In the subgroup analysis, women after PRT (n = 60) reported poorer social functioning, less sexual enjoyment, and higher symptoms experience than women after RHL and adjuvant radiotherapy (n = 60). The latter reported more lymphedema. Conclusions: Although global health scores are not significantly different, women after PRT report more physical, social, and sexual symptoms. These results can be well used by physicians to inform their patients about treatment-related morbidity. |
| التعليقات: | Comment in: Int J Gynecol Cancer. 2017 Oct;27(8):1570. (PMID: 28945210) |
| تواريخ الأحداث: | Date Created: 20161217 Date Completed: 20180105 Latest Revision: 20181030 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1097/IGC.0000000000000880 |
| PMID: | 27984376 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1525-1438 |
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| DOI: | 10.1097/IGC.0000000000000880 |