دورية أكاديمية
Anion Recognition as a Supramolecular Switch of Cell Internalization.
العنوان: | Anion Recognition as a Supramolecular Switch of Cell Internalization. |
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المؤلفون: | Rodríguez J; Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain., Mosquera J; Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.; Department of Chemistry, The University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom., Couceiro JR; Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain., Nitschke JR; Department of Chemistry, The University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom., Vázquez ME; Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain., Mascareñas JL; Department of Chemistry, The University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom. |
المصدر: | Journal of the American Chemical Society [J Am Chem Soc] 2017 Jan 11; Vol. 139 (1), pp. 55-58. Date of Electronic Publication: 2016 Dec 21. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Washington, DC : American Chemical Society Original Publication: Easton, Pa. [etc.] |
مواضيع طبية MeSH: | Cell Membrane/*chemistry , Macromolecular Substances/*chemistry, Animals ; Anions/chemistry ; Chlorocebus aethiops ; Molecular Structure ; Vero Cells |
مستخلص: | The cell internalization of designed oligoarginine peptides equipped with six glutamic acid residues and an anionic pyranine at the N-terminus is triggered upon addition of a supramolecular host. This host binds specifically to the pyranine moiety, enabling the complex to traverse the cell membrane. Interestingly, none of the components, neither the host nor the guest, are able to cross the cell membrane on their own. |
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معلومات مُعتمدة: | 340055 International ERC_ European Research Council |
المشرفين على المادة: | 0 (Anions) 0 (Macromolecular Substances) |
تواريخ الأحداث: | Date Created: 20161218 Date Completed: 20170825 Latest Revision: 20231112 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC5389450 |
DOI: | 10.1021/jacs.6b11103 |
PMID: | 27984855 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1520-5126 |
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DOI: | 10.1021/jacs.6b11103 |