دورية أكاديمية
أعرض في EDS

Intake of n-3 fatty acids and long-term outcome in renal transplant recipients: a post hoc analysis of a prospective cohort study.

التفاصيل البيبلوغرافية
العنوان: Intake of n-3 fatty acids and long-term outcome in renal transplant recipients: a post hoc analysis of a prospective cohort study.
المؤلفون: Pranger IG; 1Internal Medicine,University of Groningen and University Medical Center Groningen,PO Box 30.001, 9700 RB Groningen,The Netherlands., Gruppen EG; 1Internal Medicine,University of Groningen and University Medical Center Groningen,PO Box 30.001, 9700 RB Groningen,The Netherlands., van den Berg E; 1Internal Medicine,University of Groningen and University Medical Center Groningen,PO Box 30.001, 9700 RB Groningen,The Netherlands., Soedamah-Muthu SS; 3Division of Human Nutrition,Wageningen University,Stippeneng 4, 6708 WE Wageningen,The Netherlands., Navis G; 1Internal Medicine,University of Groningen and University Medical Center Groningen,PO Box 30.001, 9700 RB Groningen,The Netherlands., Gans RO; 1Internal Medicine,University of Groningen and University Medical Center Groningen,PO Box 30.001, 9700 RB Groningen,The Netherlands., Muskiet FA; 2Laboratory Medicine,University of Groningen and University Medical Center Groningen,PO Box 30.001, 9700 RB Groningen,The Netherlands., Kema IP; 2Laboratory Medicine,University of Groningen and University Medical Center Groningen,PO Box 30.001, 9700 RB Groningen,The Netherlands., Joosten MM; 1Internal Medicine,University of Groningen and University Medical Center Groningen,PO Box 30.001, 9700 RB Groningen,The Netherlands., Bakker SJ; 1Internal Medicine,University of Groningen and University Medical Center Groningen,PO Box 30.001, 9700 RB Groningen,The Netherlands.
المصدر: The British journal of nutrition [Br J Nutr] 2016 Dec; Vol. 116 (12), pp. 2066-2073. Date of Electronic Publication: 2016 Dec 20.
نوع المنشور: Comparative Study; Journal Article; Observational Study
اللغة: English
بيانات الدورية: Publisher: Published on behalf of the Nutrition Society by CABI Publishing Country of Publication: England NLM ID: 0372547 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-2662 (Electronic) Linking ISSN: 00071145 NLM ISO Abbreviation: Br J Nutr Subsets: MEDLINE
أسماء مطبوعة: Publication: <2000->: Wallingford, Oxon, UK : Published on behalf of the Nutrition Society by CABI Publishing
Original Publication: [Cambridge, New York] Cambridge University Press.
مواضيع طبية MeSH: Diet/*adverse effects , Dietary Supplements/*adverse effects , Kidney Transplantation/*adverse effects , alpha-Linolenic Acid/*adverse effects, Adolescent ; Adult ; Aged ; Cohort Studies ; Docosahexaenoic Acids/administration & dosage ; Docosahexaenoic Acids/adverse effects ; Docosahexaenoic Acids/therapeutic use ; Eicosapentaenoic Acid/administration & dosage ; Eicosapentaenoic Acid/adverse effects ; Eicosapentaenoic Acid/therapeutic use ; End Stage Liver Disease/surgery ; Female ; Follow-Up Studies ; Graft Rejection/epidemiology ; Graft Rejection/mortality ; Graft Rejection/prevention & control ; Humans ; Male ; Middle Aged ; Mortality ; Netherlands/epidemiology ; Proportional Hazards Models ; Prospective Studies ; Risk ; Self Report ; Young Adult ; alpha-Linolenic Acid/administration & dosage ; alpha-Linolenic Acid/therapeutic use
مستخلص: Supplementation with n-3 fatty acids may improve long-term outcomes of renal transplant recipients (RTR). Recent evidence suggests that EPA and DHA have different outcomes compared with α-linolenic acid (ALA). We examined the prospective associations of EPA-DHA and ALA intakes with graft failure and all-cause mortality in 637 RTR. During 3·1 years (interquartile range 2·7, 3·8) of follow-up, forty-one developed graft failure and sixty-seven died. In age- and sex-adjusted analyses, EPA-DHA and ALA intakes were not associated with graft failure. EPA-DHA intake was not significantly associated with mortality (hazard ratio (HR) 0·79; 95% CI 0·54, 1·15 per 0·1 energy% difference). ALA intake was significantly associated with mortality (HR 1·17; 95% CI 1·04, 1·31 per 0·1 energy% difference). This association remained following adjustments for BMI, proteinuria and intakes of fat, carbohydrate and protein. RTR in the highest tertile of ALA intake exhibited about 2-fold higher mortality risk (HR 2·21; 95% CI 1·23, 3·97) compared with the lowest tertile. In conclusion, ALA intake may be associated with increased mortality in RTR. Future RCT are needed to confirm these results.
فهرسة مساهمة: Keywords: n-3 Fatty acids; ALA α-linolenic acid; En% energy percentage; HR hazard ratio; IQR interquartile range; RTR renal transplant recipients; Graft failure; Mortality; Renal transplant recipients
المشرفين على المادة: 0RBV727H71 (alpha-Linolenic Acid)
25167-62-8 (Docosahexaenoic Acids)
AAN7QOV9EA (Eicosapentaenoic Acid)
تواريخ الأحداث: Date Created: 20161221 Date Completed: 20170512 Latest Revision: 20170512
رمز التحديث: 20240628
DOI: 10.1017/S0007114516004207
PMID: 27993180
قاعدة البيانات: MEDLINE
الوصف
تدمد:1475-2662
DOI:10.1017/S0007114516004207