دورية أكاديمية
Neuroprotective and Ameliorating Impacts of Omega-3 Against Aspartame-induced Neuronal and Astrocytic Degeneration.
| العنوان: | Neuroprotective and Ameliorating Impacts of Omega-3 Against Aspartame-induced Neuronal and Astrocytic Degeneration. |
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| المؤلفون: | Ali EMT; Department of Anatomy, Faculty of Medicine, Mansoura University, Egypt.; Department of Anatomy, Taibah University, Kingdom of Saudi Arabia., Sonpol HMA; Department of Anatomy, Faculty of Medicine, Mansoura University, Egypt. |
| المصدر: | Anatomical record (Hoboken, N.J. : 2007) [Anat Rec (Hoboken)] 2017 Jul; Vol. 300 (7), pp. 1290-1298. Date of Electronic Publication: 2017 Jan 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101292775 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-8494 (Electronic) Linking ISSN: 19328486 NLM ISO Abbreviation: Anat Rec (Hoboken) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Hoboken, NJ : John Wiley & Sons, 2007- |
| مواضيع طبية MeSH: | Aspartame/*adverse effects , Astrocytes/*drug effects , Fatty Acids, Omega-3/*pharmacology , Nerve Degeneration/*prevention & control , Neurons/*drug effects , Neuroprotective Agents/*pharmacology , Spinal Cord/*drug effects, Animals ; Astrocytes/pathology ; Male ; Nerve Degeneration/chemically induced ; Neurons/pathology ; Rats ; Spinal Cord/pathology |
| مستخلص: | Aspartame (ASP) is one of the commonest artificial sweetener used all over the world and considered as an extremely risky compound and raises a lot of controversy. Therefore, this study was designed to investigate cellular damage of the anterior horn cells in the spinal cord of albino male rats and the possibility of hindering these changes by using omega-3 (OM3).Thirty seven adult male albino rats were divided into three groups: Control, ASP-treated and ASP + OM3-treated groups. Spinal cord sections were prepared and stained with Hx&E, caspase-3 and GFAP immunostaining. All data were morphometrically and statistically analyzed. In ASP-treated group, the cell body of some degenerated neurons was swollen and its cytoplasm was vacuolated. Their nuclei were eccentric and pyknotic. Moreover, other neurons were of a heterogeneous pattern in the form of cell body shrinkage, loss of Nissl substance, intensely stained eosinophilic cytoplasm and a small darkly stained nucleus that may eventually fragment. However, the cells were apparently normal in ASP+ OM3-treated group. Strong +ve caspase-3 stained neurons were detected in ASP-treated group. Furthermore, the immunoreaction was faint on treating the rats with both ASP and OM3. Few number of +ve GFAP- stained astrocytes were observed in ASP-treated rats. On the other hand, the immunoreactivity for GFAP was found to be intense in the ASP + OM3-treated group. Additionally, there was a significant decrease in the surface area percentage of the +ve GFAP-stained astrocytes of the ASP-treated group compared to the control and the ASP + OM3-treated groups. Anat Rec, 300:1290-1298, 2017. © 2017 Wiley Periodicals, Inc. (© 2017 Wiley Periodicals, Inc.) |
| فهرسة مساهمة: | Keywords: GFAP; anterior horn cells; aspartame; astrocytes; caspase-3; omega-3 |
| المشرفين على المادة: | 0 (Fatty Acids, Omega-3) 0 (Neuroprotective Agents) Z0H242BBR1 (Aspartame) |
| تواريخ الأحداث: | Date Created: 20161221 Date Completed: 20180326 Latest Revision: 20180326 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1002/ar.23536 |
| PMID: | 27998013 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1932-8494 |
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| DOI: | 10.1002/ar.23536 |