دورية أكاديمية
Is there a relationship between tryptophan dietary intake and plasma levels of indoxyl sulfate in chronic kidney disease patients on hemodialysis?
| العنوان: | Is there a relationship between tryptophan dietary intake and plasma levels of indoxyl sulfate in chronic kidney disease patients on hemodialysis? |
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| المؤلفون: | Brito JS; Universidade Federal Fluminense, Brazil., Borges NA; Universidade Federal Fluminense, Brazil., Dolenga CJ; Universidade Federal do Paraná, Brazil., Carraro-Eduardo JC; Universidade Federal Fluminense, Brazil., Nakao LS; Universidade Federal do Paraná, Brazil., Mafra D; Universidade Federal Fluminense, Brazil. |
| المصدر: | Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia [J Bras Nefrol] 2016 Dec; Vol. 38 (4), pp. 396-402. |
| نوع المنشور: | Journal Article |
| اللغة: | Portuguese; English |
| بيانات الدورية: | Publisher: Sociedade Brasileira de Nefrologia Country of Publication: Brazil NLM ID: 9426946 Publication Model: Print Cited Medium: Internet ISSN: 2175-8239 (Electronic) Linking ISSN: 01012800 NLM ISO Abbreviation: J Bras Nefrol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: São Paulo : Sociedade Brasileira de Nefrologia Original Publication: São Paulo, Brazil : Associação Medica Brasileira |
| مواضيع طبية MeSH: | Diet* , Renal Dialysis*, Indican/*blood , Kidney Failure, Chronic/*blood , Kidney Failure, Chronic/*therapy , Tryptophan/*administration & dosage, Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged |
| مستخلص: | Introduction: Gut microbiota is involved in generation of uremic toxins in chronic kidney disease (CKD) patients on hemodialysis (HD), like indoxyl sulfate (IS) that is originated from tryptophan amino acid fermentation. Objective: To evaluate the tryptophan intake by chronic renal failure patients on HD and its possible relationship with IS plasma levels. Methods: Participated of the study 46 patients with CKD on HD regular program (56.5% men; 52.7 ± 10.3 years; 63 (32.2-118.2) months on HD; BMI 25.6 ± 4.9 kg/m2). The tryptophan intake was evaluated by a 24-hours dietary recall (R-24h) performed on 3 different days. Routine biochemical tests and anthropometric measurements were evaluated. IS plasma levels were determined by High Performance Liquid Chromatography (HPLC) with fluorescent detection and the interleukin-6 (IL-6) plasma levels by immunoenzymatic method (ELISA, Enzyme Linked Immunosorbent Assay). Results: The average of tryptophan intake was according to recommendation, but IS plasma levels (35.0 ± 11.9 mg/L) were elevated, however according to the EUTox values for uremic individuals. There was no correlation between the tryptophan intake and IS plasma levels. However, there was positive correlation between protein intake and tryptophan and variables used to evaluate lean body mass, and moreover, IS levels were positively associated with IL-6 (r = 0.6: p = 0.01). Conclusion: The present study suggests that tryptophan dietary intake may not be a determinant factor to IS levels. However, it suggests that gut microbiota may play an important role in systemic inflammation in patients with CKD. |
| المشرفين على المادة: | 8DUH1N11BX (Tryptophan) N187WK1Y1J (Indican) |
| تواريخ الأحداث: | Date Created: 20161222 Date Completed: 20180129 Latest Revision: 20180129 |
| رمز التحديث: | 20221213 |
| DOI: | 10.5935/0101-2800.20160064 |
| PMID: | 28001180 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2175-8239 |
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| DOI: | 10.5935/0101-2800.20160064 |