دورية أكاديمية
Bromfenac eyedrops in the treatment of diabetic macular edema: a pilot study.
| العنوان: | Bromfenac eyedrops in the treatment of diabetic macular edema: a pilot study. |
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| المؤلفون: | Pinna A; Department of Surgical, Microsurgical and Medical Sciences, Section of Ophthalmology, University of Sassari, Sassari - Italy., Blasetti F; Department of Surgical, Microsurgical and Medical Sciences, Section of Ophthalmology, University of Sassari, Sassari - Italy., Ricci GD; Department of Surgical, Microsurgical and Medical Sciences, Section of Ophthalmology, University of Sassari, Sassari - Italy., Boscia F; Department of Surgical, Microsurgical and Medical Sciences, Section of Ophthalmology, University of Sassari, Sassari - Italy. |
| المصدر: | European journal of ophthalmology [Eur J Ophthalmol] 2017 May 11; Vol. 27 (3), pp. 326-330. Date of Electronic Publication: 2016 Nov 16. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: SAGE Publishing Country of Publication: United States NLM ID: 9110772 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1724-6016 (Electronic) Linking ISSN: 11206721 NLM ISO Abbreviation: Eur J Ophthalmol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2018- : Thousand Oaks, CA : SAGE Publishing Original Publication: Milano ; Birmingham, AL : Wichtig, c1991- |
| مواضيع طبية MeSH: | Visual Acuity*, Benzophenones/*administration & dosage , Bromobenzenes/*administration & dosage , Diabetic Retinopathy/*drug therapy , Macular Edema/*drug therapy, Adult ; Aged ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Diabetic Retinopathy/complications ; Diabetic Retinopathy/diagnosis ; Female ; Humans ; Macula Lutea/pathology ; Macular Edema/diagnosis ; Macular Edema/etiology ; Male ; Middle Aged ; Ophthalmic Solutions ; Pilot Projects ; Tomography, Optical Coherence ; Treatment Outcome |
| مستخلص: | Purpose: To evaluate the efficacy and safety of topical bromfenac in patients with newly diagnosed diabetic macular edema (DME). Methods: In this pilot study including 17 patients with monocular, newly diagnosed DME, diagnosis of DME was established by the detection of retinal thickening at or within 500 μm of the center of the macula on ophthalmoscopic examination, according to the Early Treatment Diabetic Retinopathy Study classification. Central macular thickness (CMT) was determined by optical coherence tomography. Bromfenac sodium hydrate 0.9 mg/mL eyedrops were administered in the affected eye twice daily for 30 days. Primary endpoints were changes in best-corrected visual acuity (BCVA) and CMT at the end of therapy. Results: Topical bromfenac significantly reduced mean CMT, from 465.41 ± 118.47 μm at baseline to 388.88 ± 152.63 μm posttreatment (p = 0.02). There was no significant change in BCVA and differences in mean macular volume fell just short of statistical significance (p = 0.06). Treatment was well-tolerated, and there were no topical or systemic side effects. Conclusions: Topical bromfenac twice daily may play a role in the reduction of DME. These preliminary results warrant further larger multicenter studies to confirm our findings and establish whether topical bromfenac may be of long-term benefit in the treatment of DME. |
| المشرفين على المادة: | 0 (Anti-Inflammatory Agents, Non-Steroidal) 0 (Benzophenones) 0 (Bromobenzenes) 0 (Ophthalmic Solutions) 864P0921DW (bromfenac) |
| تواريخ الأحداث: | Date Created: 20161224 Date Completed: 20170531 Latest Revision: 20181202 |
| رمز التحديث: | 20231215 |
| DOI: | 10.5301/ejo.5000888 |
| PMID: | 28009414 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1724-6016 |
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| DOI: | 10.5301/ejo.5000888 |