دورية أكاديمية
أعرض في EDS

Placental methylome analysis from a prospective autism study.

التفاصيل البيبلوغرافية
العنوان: Placental methylome analysis from a prospective autism study.
المؤلفون: Schroeder DI; Department of Medical Microbiology and Immunology, Genome Center, Davis, CA 95616 USA., Schmidt RJ; Department of Public Health Sciences, University of California, Davis, CA 95616 USA ; MIND Institute, University of California, Davis, CA 95616 USA., Crary-Dooley FK; Department of Medical Microbiology and Immunology, Genome Center, Davis, CA 95616 USA., Walker CK; Department of Obstetrics and Gynecology, University of California, Davis, CA 95616 USA ; MIND Institute, University of California, Davis, CA 95616 USA., Ozonoff S; Department of Psychiatry and Behavioral Sciences, University of California, Davis, CA 95616 USA ; MIND Institute, University of California, Davis, CA 95616 USA., Tancredi DJ; Department of Pediatrics, University of California, Davis, CA 95616 USA., Hertz-Picciotto I; Department of Public Health Sciences, University of California, Davis, CA 95616 USA ; MIND Institute, University of California, Davis, CA 95616 USA., LaSalle JM; Department of Medical Microbiology and Immunology, Genome Center, Davis, CA 95616 USA ; MIND Institute, University of California, Davis, CA 95616 USA.
المصدر: Molecular autism [Mol Autism] 2016 Dec 15; Vol. 7, pp. 51. Date of Electronic Publication: 2016 Dec 15 (Print Publication: 2016).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101534222 Publication Model: eCollection Cited Medium: Internet ISSN: 2040-2392 (Electronic) NLM ISO Abbreviation: Mol Autism Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central
مواضيع طبية MeSH: Enhancer Elements, Genetic* , Epigenesis, Genetic*, Autism Spectrum Disorder/*diagnosis , Intercellular Signaling Peptides and Proteins/*genetics , Membrane Proteins/*genetics , Placenta/*metabolism, Autism Spectrum Disorder/genetics ; Biomarkers/metabolism ; Calcium-Binding Proteins ; Child, Preschool ; DNA Methylation ; Early Diagnosis ; Female ; Genome, Human ; Genome-Wide Association Study ; High-Throughput Nucleotide Sequencing ; Humans ; Infant, Newborn ; Intercellular Signaling Peptides and Proteins/metabolism ; Male ; Membrane Proteins/metabolism ; Pregnancy
مستخلص: Background: Autism spectrum disorders (ASD) are increasingly prevalent neurodevelopmental disorders that are behaviorally diagnosed in early childhood. Most ASD cases likely arise from a complex mixture of genetic and environmental factors, an interface where the epigenetic marks of DNA methylation may be useful as risk biomarkers. The placenta is a potentially useful surrogate tissue characterized by a methylation pattern of partially methylated domains (PMDs) and highly methylated domains (HMDs) reflective of methylation patterns observed in the early embryo.
Methods: In this study, we investigated human term placentas from the MARBLES (Markers of Autism Risk in Babies: Learning Early Signs) prospective study by whole genome bisulfite sequencing. We also examined the utility of PMD/HMDs in detecting methylation differences consistent with ASD diagnosis at age three.
Results: We found that while human placental methylomes have highly reproducible PMD and HMD locations, there is a greater variation between individuals in methylation levels over PMDs than HMDs due to both sampling and individual variability. In a comparison of methylation differences in placental samples from 24 ASD and 23 typically developing (TD) children, a HMD containing a putative fetal brain enhancer near DLL1 was found to reach genome-wide significance and was validated for significantly higher methylation in ASD by pyrosequencing.
Conclusions: These results suggest that the placenta could be an informative surrogate tissue for predictive ASD biomarkers in high-risk families.
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معلومات مُعتمدة: P01 ES011269 United States ES NIEHS NIH HHS; R01 ES020392 United States ES NIEHS NIH HHS; U54 HD079125 United States HD NICHD NIH HHS; S10 RR029668 United States RR NCRR NIH HHS; R01 ES025574 United States ES NIEHS NIH HHS; S10 RR027303 United States RR NCRR NIH HHS; UL1 TR000002 United States TR NCATS NIH HHS; R01 ES021707 United States ES NIEHS NIH HHS
فهرسة مساهمة: Keywords: Biomarkers; DNA methylation; Epigenetics; Genomics; Methylome; Placenta
المشرفين على المادة: 0 (Biomarkers)
0 (Calcium-Binding Proteins)
0 (DLK1 protein, human)
0 (Intercellular Signaling Peptides and Proteins)
0 (Membrane Proteins)
تواريخ الأحداث: Date Created: 20161227 Date Completed: 20171023 Latest Revision: 20191210
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5159983
DOI: 10.1186/s13229-016-0114-8
PMID: 28018572
قاعدة البيانات: MEDLINE
الوصف
تدمد:2040-2392
DOI:10.1186/s13229-016-0114-8