دورية أكاديمية
أعرض في EDS

Visual projection neurons in the Drosophila lobula link feature detection to distinct behavioral programs.

التفاصيل البيبلوغرافية
العنوان: Visual projection neurons in the Drosophila lobula link feature detection to distinct behavioral programs.
المؤلفون: Wu M; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Nern A; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Williamson WR; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Morimoto MM; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Reiser MB; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Card GM; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Rubin GM; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
المصدر: ELife [Elife] 2016 Dec 28; Vol. 5. Date of Electronic Publication: 2016 Dec 28.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Drosophila/*anatomy & histology , Drosophila/*physiology , Neurons/*cytology , Neurons/*physiology , Visual Pathways/*anatomy & histology , Visual Pathways/*physiology, Animals ; Behavior, Animal ; Optical Imaging ; Optogenetics ; Voltage-Sensitive Dye Imaging
مستخلص: Visual projection neurons (VPNs) provide an anatomical connection between early visual processing and higher brain regions. Here we characterize lobula columnar (LC) cells, a class of Drosophila VPNs that project to distinct central brain structures called optic glomeruli. We anatomically describe 22 different LC types and show that, for several types, optogenetic activation in freely moving flies evokes specific behaviors. The activation phenotypes of two LC types closely resemble natural avoidance behaviors triggered by a visual loom. In vivo two-photon calcium imaging reveals that these LC types respond to looming stimuli, while another type does not, but instead responds to the motion of a small object. Activation of LC neurons on only one side of the brain can result in attractive or aversive turning behaviors depending on the cell type. Our results indicate that LC neurons convey information on the presence and location of visual features relevant for specific behaviors.
Competing Interests: The authors declare that no competing interests exist.
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معلومات مُعتمدة: United States HHMI Howard Hughes Medical Institute
فهرسة مساهمة: Keywords: D. melanogaster; feature detection; lobula; loom detection and avoidance behaviors; neuroscience; optic glomeruli; retinotopy; visual behavior
تواريخ الأحداث: Date Created: 20161229 Date Completed: 20171023 Latest Revision: 20181113
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5293491
DOI: 10.7554/eLife.21022
PMID: 28029094
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.21022