دورية أكاديمية
Visual projection neurons in the Drosophila lobula link feature detection to distinct behavioral programs.
العنوان: | Visual projection neurons in the Drosophila lobula link feature detection to distinct behavioral programs. |
---|---|
المؤلفون: | Wu M; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Nern A; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Williamson WR; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Morimoto MM; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Reiser MB; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Card GM; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Rubin GM; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States. |
المصدر: | ELife [Elife] 2016 Dec 28; Vol. 5. Date of Electronic Publication: 2016 Dec 28. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012- |
مواضيع طبية MeSH: | Drosophila/*anatomy & histology , Drosophila/*physiology , Neurons/*cytology , Neurons/*physiology , Visual Pathways/*anatomy & histology , Visual Pathways/*physiology, Animals ; Behavior, Animal ; Optical Imaging ; Optogenetics ; Voltage-Sensitive Dye Imaging |
مستخلص: | Visual projection neurons (VPNs) provide an anatomical connection between early visual processing and higher brain regions. Here we characterize lobula columnar (LC) cells, a class of Drosophila VPNs that project to distinct central brain structures called optic glomeruli. We anatomically describe 22 different LC types and show that, for several types, optogenetic activation in freely moving flies evokes specific behaviors. The activation phenotypes of two LC types closely resemble natural avoidance behaviors triggered by a visual loom. In vivo two-photon calcium imaging reveals that these LC types respond to looming stimuli, while another type does not, but instead responds to the motion of a small object. Activation of LC neurons on only one side of the brain can result in attractive or aversive turning behaviors depending on the cell type. Our results indicate that LC neurons convey information on the presence and location of visual features relevant for specific behaviors. Competing Interests: The authors declare that no competing interests exist. |
التعليقات: | Comment in: Elife. 2017 Feb 06;6:. (PMID: 28165325) |
References: | J Exp Biol. 2008 Feb;211(Pt 3):341-53. (PMID: 18203989) J Comp Neurol. 2016 Feb 1;524(2):213-27. (PMID: 26179639) J Comp Neurol. 1999 Mar 22;405(4):543-52. (PMID: 10098944) Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):E2967-76. (PMID: 25964354) J Exp Biol. 2010 May;213(Pt 10):1771-81. (PMID: 20435828) Science. 2014 Apr 11;344(6180):172-7. (PMID: 24723606) Neuron. 2010 Jan 28;65(2):150-64. (PMID: 20152123) J Neurophysiol. 2005 Dec;94(6):3903-15. (PMID: 16049147) Neuron. 2013 Jul 10;79(1):128-40. (PMID: 23849200) Nat Methods. 2015 Jun;12(6):568-76. (PMID: 25915120) Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):E5523-32. (PMID: 26324910) Science. 2004 Aug 13;305(5686):1020-2. (PMID: 15310908) Nature. 2011 Jun 08;474(7350):204-7. (PMID: 21654803) Nature. 2013 Nov 14;503(7475):262-6. (PMID: 24107996) J Neurosci. 2012 May 2;32(18):6061-71. (PMID: 22553013) J Neurosci Methods. 2008 Jan 30;167(2):127-39. (PMID: 17854905) Annu Rev Neurosci. 2010;33:49-70. (PMID: 20225934) Neuron. 2016 Feb 3;89(3):629-44. (PMID: 26844835) Neuron. 2014 Feb 19;81(4):755-65. (PMID: 24559671) Cell Rep. 2014 Aug 7;8(3):897-908. (PMID: 25088417) Neuron. 2008 Oct 23;60(2):328-42. (PMID: 18957224) Nature. 2013 Jul 4;499(7456):83-7. (PMID: 23748445) Front Neural Circuits. 2014 Feb 10;8:8. (PMID: 24574974) Elife. 2014 Dec 23;3:e04580. (PMID: 25535794) Vis Neurosci. 1994 Nov-Dec;11(6):1149-61. (PMID: 7841123) Basic Life Sci. 1980;16:391-407. (PMID: 6779803) Curr Biol. 2014 May 5;24(9):976-83. (PMID: 24704075) Neuron. 2011 Jan 13;69(1):147-58. (PMID: 21220105) Nat Neurosci. 2014 Jul;17 (7):962-70. (PMID: 24908103) Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):E2391-8. (PMID: 22891316) Neuron. 2016 Jul 20;91(2):293-311. (PMID: 27373836) Neuron. 2011 Feb 10;69(3):509-22. (PMID: 21315261) Curr Biol. 2008 Sep 9;18(17):1300-7. (PMID: 18760606) J Comp Neurol. 2006 Aug 20;497(6):928-58. (PMID: 16802334) J Neurocytol. 1983 Dec;12(6):971-91. (PMID: 6420522) Cell. 1993 Feb 26;72(4):527-40. (PMID: 8440019) Nature. 2013 Jul 18;499(7458):295-300. (PMID: 23868258) Neuron. 2006 Mar 16;49(6):833-44. (PMID: 16543132) Annu Rev Entomol. 2014;59:165-84. (PMID: 24160424) Neuron. 2010 Apr 15;66(1):15-36. (PMID: 20399726) Curr Biol. 2012 Mar 6;22(5):353-62. (PMID: 22305754) J Neurosci. 1999 Feb 1;19(3):1122-41. (PMID: 9920674) Elife. 2014 Dec 23;3:e04577. (PMID: 25535793) Nat Biotechnol. 2010 Apr;28(4):348-53. (PMID: 20231818) Curr Biol. 2013 Apr 22;23(8):644-55. (PMID: 23541729) Cell Rep. 2012 Oct 25;2(4):991-1001. (PMID: 23063364) J Neurosci. 2015 May 13;35(19):7587-99. (PMID: 25972183) J Comp Neurol. 2007 Jan 1;500(1):166-88. (PMID: 17099891) Neuron. 2014 Feb 5;81(3):603-15. (PMID: 24507194) Curr Opin Neurobiol. 2012 Apr;22(2):180-6. (PMID: 22226514) J Exp Biol. 2002 Sep;205(Pt 18):2785-98. (PMID: 12177144) Dev Neurobiol. 2007 Sep 1;67(10):1267-88. (PMID: 17638381) Science. 2014 Apr 4;344(6179):97-101. (PMID: 24700860) Naturwissenschaften. 1969 Aug;56(8):424-5. (PMID: 5362004) Cell. 2005 Apr 8;121(1):141-52. (PMID: 15820685) Neuron. 2000 Mar;25(3):549-61. (PMID: 10774724) Biol Open. 2015 Jul 31;4(9):1105-8. (PMID: 26231626) J Neurophysiol. 1998 Apr;79(4):1902-17. (PMID: 9535957) Nature. 2013 Jan 17;493(7432):424-8. (PMID: 23263180) Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14198-203. (PMID: 21831835) Elife. 2013 Mar 05;2:e00337. (PMID: 23471010) Neuron. 2006 Nov 9;52(3):425-36. (PMID: 17088209) Nature. 2013 Aug 8;500(7461):175-81. (PMID: 23925240) Curr Biol. 2016 Oct 24;26(20):R976-R980. (PMID: 27780072) Curr Biol. 2016 Aug 8;26(15):1943-54. (PMID: 27426516) Nat Neurosci. 2009 Oct;12 (10 ):1308-16. (PMID: 19734895) Curr Biol. 2011 Jan 11;21(1):1-11. (PMID: 21129968) Annu Rev Neurosci. 2011;34:1-19. (PMID: 21391815) J Exp Biol. 2010 Jul 15;213(Pt 14):2494-506. (PMID: 20581279) Nature. 2006 Feb 2;439(7076):551-6. (PMID: 16452971) Nat Rev Neurosci. 2014 Sep;15(9):590-9. (PMID: 25116140) Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5664-8. (PMID: 11960020) J Neurogenet. 2014 Sep-Dec;28(3-4):374-88. (PMID: 24766346) Genetics. 2010 Oct;186(2):735-55. (PMID: 20697123) Curr Biol. 2013 Oct 21;23(20):2011-5. (PMID: 24120636) IEEE Pac Vis Symp. 2012;:201-208. (PMID: 23584131) J Neurophysiol. 2009 Aug;102(2):875-85. (PMID: 19474177) Curr Biol. 2005 Aug 23;15(16):1473-8. (PMID: 16111941) Nat Methods. 2014 Mar;11(3):338-46. (PMID: 24509633) Curr Biol. 2008 Mar 25;18(6):464-70. (PMID: 18342508) Nat Neurosci. 2013 Jun;16(6):730-8. (PMID: 23624513) J Comp Physiol A. 1991 Oct;169(4):451-9. (PMID: 1779418) Nature. 2014 Aug 7;512(7512):91-5. (PMID: 24896182) Vision Res. 1999 Nov;39(23):3920-33. (PMID: 10748925) Curr Biol. 2012 Mar 20;22(6):482-7. (PMID: 22386313) J Comp Neurol. 1998 Jun 22;396(1):84-104. (PMID: 9623889) |
معلومات مُعتمدة: | United States HHMI Howard Hughes Medical Institute |
فهرسة مساهمة: | Keywords: D. melanogaster; feature detection; lobula; loom detection and avoidance behaviors; neuroscience; optic glomeruli; retinotopy; visual behavior |
تواريخ الأحداث: | Date Created: 20161229 Date Completed: 20171023 Latest Revision: 20181113 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC5293491 |
DOI: | 10.7554/eLife.21022 |
PMID: | 28029094 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2050-084X |
---|---|
DOI: | 10.7554/eLife.21022 |