دورية أكاديمية
أعرض في EDS

Increased IL17A, IFNG, and FOXP3 Transcripts in Moderate-Severe Psoriasis: A Major Influence Exerted by IL17A in Disease Severity.

التفاصيل البيبلوغرافية
العنوان: Increased IL17A, IFNG, and FOXP3 Transcripts in Moderate-Severe Psoriasis: A Major Influence Exerted by IL17A in Disease Severity.
المؤلفون: de Oliveira PS; Laboratório de Imunomodulação e Novas Abordagens Terapêuticas (LINAT), Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino (NUPIT-SG), Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil., Pereira MC; Laboratório de Imunomodulação e Novas Abordagens Terapêuticas (LINAT), Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino (NUPIT-SG), Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil., Silva de Paula SK; Laboratório de Imunomodulação e Novas Abordagens Terapêuticas (LINAT), Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino (NUPIT-SG), Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil., Lima EV; Hospital das Clínicas, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil., Lima MM; Hospital das Clínicas, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil., de Arruda RG; Faculdade Nova Roma, Recife, PE, Brazil., de Oliveira WL; Laboratório de Imunomodulação e Novas Abordagens Terapêuticas (LINAT), Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino (NUPIT-SG), Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil., Duarte ÂL; Hospital das Clínicas, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil., Pitta ID; Laboratório de Imunomodulação e Novas Abordagens Terapêuticas (LINAT), Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino (NUPIT-SG), Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil., Rêgo MJ; Laboratório de Imunomodulação e Novas Abordagens Terapêuticas (LINAT), Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino (NUPIT-SG), Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil., Galdino da Rocha Pitta M; Laboratório de Imunomodulação e Novas Abordagens Terapêuticas (LINAT), Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino (NUPIT-SG), Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil.
المصدر: Mediators of inflammation [Mediators Inflamm] 2016; Vol. 2016, pp. 4395276. Date of Electronic Publication: 2016 Nov 30.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 9209001 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1466-1861 (Electronic) Linking ISSN: 09629351 NLM ISO Abbreviation: Mediators Inflamm Subsets: MEDLINE
أسماء مطبوعة: Publication: 2005- : Sylvania, OH : Hindawi Pub. Corp.
Original Publication: Oxford, UK : Rapid Communications of Oxford Ltd., c1992-
مواضيع طبية MeSH: Forkhead Transcription Factors/*metabolism , Interferon-gamma/*metabolism , Interleukin-17/*metabolism , Psoriasis/*metabolism, Adult ; Aged ; Brazil ; Cohort Studies ; Comorbidity ; Cytokines/metabolism ; Dermatology ; Female ; Humans ; Male ; Middle Aged ; Psoriasis/drug therapy ; Skin/metabolism ; Skin/pathology ; Th1 Cells/metabolism ; Th17 Cells/metabolism ; Young Adult
مستخلص: Psoriasis is a chronic and recurrent dermatitis, mediated by keratinocytes and T cells. Several proinflammatory cytokines contribute to formation and maintenance of psoriatic plaque. The Th1/Th17 pathways and some of IL-1 family members were involved in psoriasis pathogenesis and could contribute to disease activity. Therefore, we sought to analyse skin transcript levels of IL17A, IL22, RORC, IL8, IFNG, IL33, IL36A, FOXP3, and IL10 and correlate with clinic of patients with plaque-type psoriasis. In order to conduct that, we collected punch biopsies from lesional skin and obtained tissue RNA. After reverse transcription, qRT-PCR quantified the relative mRNA expression. The main results revealed increased transcripts levels of IL17A, IFNG, and FOXP3 in moderate-severe patients. Despite this, only IL17A can increase the chance to worsen disease severity. We also observed many significant positive correlations between each transcript. In conclusion, IL17A is elevated in lesional skin from psoriasis patients and plays crucial role in disease severity.
Competing Interests: All authors declare no conflict of interests.
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المشرفين على المادة: 0 (Cytokines)
0 (FOXP3 protein, human)
0 (Forkhead Transcription Factors)
0 (IFNG protein, human)
0 (IL17A protein, human)
0 (Interleukin-17)
82115-62-6 (Interferon-gamma)
تواريخ الأحداث: Date Created: 20170103 Date Completed: 20170804 Latest Revision: 20181113
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5155088
DOI: 10.1155/2016/4395276
PMID: 28042206
قاعدة البيانات: MEDLINE
الوصف
تدمد:1466-1861
DOI:10.1155/2016/4395276