دورية أكاديمية
أعرض في EDS

Protocol for intraoperative assessment of the human cerebrovascular glycocalyx.

التفاصيل البيبلوغرافية
العنوان: Protocol for intraoperative assessment of the human cerebrovascular glycocalyx.
المؤلفون: Haeren RH; Department of Neurosurgery, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands., Vink H; Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands., Staals J; Department of Neurology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands., van Zandvoort MA; Department of Genetics & Cell Biology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.; Institute for Molecular Cardiovascular Research, IMCAR, Universitätsklinikum, Aachen University, Aachen, Germany., Dings J; Department of Neurosurgery, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.; Academic Center for Epileptology, Maastricht University Medical Center and Kempenhaeghe, Maastricht/Heeze, The Netherlands., van Overbeeke JJ; Department of Neurosurgery, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.; Academic Center for Epileptology, Maastricht University Medical Center and Kempenhaeghe, Maastricht/Heeze, The Netherlands., Hoogland G; Department of Neurosurgery, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.; Academic Center for Epileptology, Maastricht University Medical Center and Kempenhaeghe, Maastricht/Heeze, The Netherlands., Rijkers K; Department of Neurosurgery, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.; Department of Neurosurgery, Zuyderland Medical Center, Heerlen, The Netherlands., Schijns OE; Department of Neurosurgery, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.; Academic Center for Epileptology, Maastricht University Medical Center and Kempenhaeghe, Maastricht/Heeze, The Netherlands.
المصدر: BMJ open [BMJ Open] 2017 Jan 05; Vol. 7 (1), pp. e013954. Date of Electronic Publication: 2017 Jan 05.
نوع المنشور: Journal Article; Multicenter Study; Observational Study
اللغة: English
بيانات الدورية: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BMJ Publishing Group Ltd, 2011-
مواضيع طبية MeSH: Blood-Brain Barrier/*diagnostic imaging , Epilepsy, Temporal Lobe/*diagnostic imaging , Epilepsy, Temporal Lobe/*pathology , Glycocalyx/*pathology , Microvessels/*diagnostic imaging, Adolescent ; Adult ; Blood-Brain Barrier/physiopathology ; Case-Control Studies ; Cerebral Cortex/blood supply ; Epilepsy, Temporal Lobe/surgery ; Glycocalyx/physiology ; Hippocampus/blood supply ; Humans ; Intraoperative Care ; Microscopy, Video/methods ; Microvessels/physiopathology ; Middle Aged ; Mouth Floor/blood supply ; Organ Size ; Prospective Studies ; Research Design ; Young Adult
مستخلص: Introduction: Adequate functioning of the blood-brain barrier (BBB) is important for brain homoeostasis and normal neuronal function. Disruption of the BBB has been described in several neurological diseases. Recent reports suggest that an increased permeability of the BBB also contributes to increased seizure susceptibility in patients with epilepsy. The endothelial glycocalyx is coating the luminal side of the endothelium and can be considered as the first barrier of the BBB. We hypothesise that an altered glycocalyx thickness plays a role in the aetiology of temporal lobe epilepsy (TLE), the most common type of epilepsy. Here, we propose a protocol that allows intraoperative assessment of the cerebrovascular glycocalyx thickness in patients with TLE and assess whether its thickness is decreased in patients with TLE when compared with controls.
Methods and Analysis: This protocol is designed as a prospective observational case-control study in patients who undergo resective brain surgery as treatment for TLE. Control subjects are patients without a history of epileptic seizures, who undergo a craniotomy or burr hole surgery for other indications. Intraoperative glycocalyx thickness measurements of sublingual, cortical and hippocampal microcirculation are performed by video microscopy using sidestream dark-field imaging. Demographic details, seizure characteristics, epilepsy risk factors, intraoperative haemodynamic parameters and histopathological evaluation are additionally recorded.
Ethics and Dissemination: This protocol has been ethically approved by the local medical ethical committee (ID: NL51594.068.14) and complies with the Declaration of Helsinki and principles of Good Clinical Practice. Informed consent is obtained before study enrolment and only coded data will be stored in a secured database, enabling an audit trail. Results will be submitted to international peer-reviewed journals and presented at international conferences.
Trial Registration Number: NTR5568.
Competing Interests: HV is the Chief Science Officer at GlycoCheck BV.
(Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.)
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فهرسة مساهمة: Keywords: Blood-brain barrier; Glycocalyx; Sidestream darkfield imaging; Temporal lobe epilepsy; observational study
سلسلة جزيئية: NTR NTR5568
تواريخ الأحداث: Date Created: 20170107 Date Completed: 20171215 Latest Revision: 20181113
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5223665
DOI: 10.1136/bmjopen-2016-013954
PMID: 28057660
قاعدة البيانات: MEDLINE
الوصف
تدمد:2044-6055
DOI:10.1136/bmjopen-2016-013954