دورية أكاديمية
أعرض في EDS

Practical use of visual medial temporal lobe atrophy cut-off scores in Alzheimer's disease: Validation in a large memory clinic population.

التفاصيل البيبلوغرافية
العنوان: Practical use of visual medial temporal lobe atrophy cut-off scores in Alzheimer's disease: Validation in a large memory clinic population.
المؤلفون: Claus JJ; Department of Neurology, Tergooi Hospital, Blaricum, The Netherlands., Staekenborg SS; Department of Neurology, Tergooi Hospital, Blaricum, The Netherlands.; Department of Neurology, Alzheimer Center, VU University Medical Center, de Boelelaan 1118, 1081 HZ, Amsterdam, The Netherlands., Holl DC; Department of Neurology, Tergooi Hospital, Blaricum, The Netherlands., Roorda JJ; Department of Neurology, Tergooi Hospital, Blaricum, The Netherlands., Schuur J; Department of Geriatrics, Tergooi Hospital, Blaricum, The Netherlands., Koster P; Department of Radiology, Tergooi Hospital, Blaricum, The Netherlands., Tielkes CEM; Department of Medical Psychology, Tergooi Hospital, Blaricum, The Netherlands., Scheltens P; Department of Neurology, Alzheimer Center, VU University Medical Center, de Boelelaan 1118, 1081 HZ, Amsterdam, The Netherlands. p.scheltens@vumc.nl.
المصدر: European radiology [Eur Radiol] 2017 Aug; Vol. 27 (8), pp. 3147-3155. Date of Electronic Publication: 2017 Jan 12.
نوع المنشور: Journal Article; Validation Study
اللغة: English
بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 9114774 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1084 (Electronic) Linking ISSN: 09387994 NLM ISO Abbreviation: Eur Radiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin : Springer International, c1991-
مواضيع طبية MeSH: Alzheimer Disease/*pathology , Temporal Lobe/*pathology, Aged ; Aged, 80 and over ; Alzheimer Disease/diagnosis ; Analysis of Variance ; Atrophy/pathology ; Cognitive Dysfunction/pathology ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Reference Values ; Regression Analysis ; Sensitivity and Specificity ; Tomography, X-Ray Computed
مستخلص: Objective: To provide age-specific medial temporal lobe atrophy (MTA) cut-off scores for routine clinical practice as marker for Alzheimer's disease (AD).
Methods: Patients with AD (n = 832, mean age 81.8 years) were compared with patients with subjective cognitive impairment (n = 333, mean age 71.8 years) in a large single-centre memory clinic. Mean of right and left MTA scores was determined with visual rating (Scheltens scale) using CT (0, no atrophy to 4, severe atrophy). Relationships between age and MTA scores were analysed with regression analysis. For various MTA cut-off scores, decade-specific sensitivity and specificity and area under the curve (AUC) values, computed with receiver operator characteristic curves, were determined.
Results: MTA strongly increased with age in both groups to a similar degree. Optimal MTA cut-off values for the age ranges <65, 65-74, 75-84 and ≥85 were: ≥1.0, ≥1.5, ≥ 2.0 and ≥2.0. Corresponding values of sensitivity and specificity were 83.3% and 86.4%; 73.7% and 84.6%; 73.7% and 76.2%; and 84.0% and 62.5%.
Conclusion: From this large unique memory clinic cohort we suggest decade-specific MTA cut-off scores for clinical use. After age 85 years, however, the practical usefulness of the MTA cut-off is limited.
Key Points: • We suggest decade-specific MTA cut-off scores for AD. • MTA cut-off after the age of 85 years has limited use. • CT is feasible and accurate for visual MTA rating.
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فهرسة مساهمة: Keywords: Alzheimer’s disease; Clinical practice; Computed tomography; Diagnostic imaging; Temporal lobe
تواريخ الأحداث: Date Created: 20170114 Date Completed: 20180305 Latest Revision: 20220408
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5491609
DOI: 10.1007/s00330-016-4726-3
PMID: 28083697
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-1084
DOI:10.1007/s00330-016-4726-3