دورية أكاديمية
Comparison of "Lesion-by-Lesion" and Field Photodynamic Therapy in the Prevention of Actinic Keratoses: A Randomized, Split-Face, Single-Blind Pilot Study.
| العنوان: | Comparison of "Lesion-by-Lesion" and Field Photodynamic Therapy in the Prevention of Actinic Keratoses: A Randomized, Split-Face, Single-Blind Pilot Study. |
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| المؤلفون: | Seubring I; Department of Dermatology, Radboud University Medical Center, Nijmegen, The Netherlands., Groenewoud JMM, Gerritsen MP |
| المصدر: | Dermatology (Basel, Switzerland) [Dermatology] 2016; Vol. 232 (6), pp. 708-714. Date of Electronic Publication: 2017 Jan 18. |
| نوع المنشور: | Comparative Study; Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Karger Country of Publication: Switzerland NLM ID: 9203244 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1421-9832 (Electronic) Linking ISSN: 10188665 NLM ISO Abbreviation: Dermatology Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel ; New York : Karger, c1992- |
| مواضيع طبية MeSH: | Keratosis, Actinic/*drug therapy , Keratosis, Actinic/*prevention & control , Photochemotherapy/*methods, Aged ; Aged, 80 and over ; Aminolevulinic Acid/administration & dosage ; Aminolevulinic Acid/analogs & derivatives ; Female ; Humans ; Male ; Middle Aged ; Photosensitizing Agents/administration & dosage ; Pilot Projects ; Prospective Studies ; Single-Blind Method |
| مستخلص: | Background: Actinic keratoses (AKs) are often treated separately, lesion by lesion. However, in the past years, AKs have been described as a field disease and not limited to single clinically apparent lesions. Treatment should therefore target an area of field change which may reduce the risk of development of further AKs, second tumours, and local recurrence. Objective: The primary objective was to determine the number of new lesions at 9 months after methyl aminolevulinate photodynamic therapy (MAL-PDT). Secondary objectives were to determine the number of new lesions at 3 and 6 months after treatment and the percentage reduction of AKs from baseline at 3, 6, and 9 months after MAL-PDT. Methods: This was a single-centre, prospective, randomized, split-face, investigator-blinded pilot study with a study duration of 1 year. The study population comprised patients with AKs on the face or scalp, with a maximum of 10 AKs on each side. One side was treated with 1 session of "lesion-by-lesion" MAL-PDT (LT side) and the other side with 1 session of field MAL-PDT (FT side). Results: At 9 months the FT demonstrated significantly fewer new lesions. At every time point during the follow-up, we found a significant reduction in the number of AKs in the LT as well as in the FT sides. After 3 and 6 months we did not observe significant differences between the sides. However, after 9 months, the LT area showed significantly fewer remaining AKs, whereas the FT area demonstrated significantly fewer new lesions. Conclusions: Field treatment results in significantly fewer new AK lesions compared with lesion-by-lesion treatment. (© 2017 S. Karger AG, Basel.) |
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| فهرسة مساهمة: | Keywords: Field photodynamic therapy; In-patient comparison; Lesion-by-lesion photodynamic therapy; Prevention |
| المشرفين على المادة: | 0 (Photosensitizing Agents) 585NM85KYM (methyl 5-aminolevulinate) 88755TAZ87 (Aminolevulinic Acid) |
| تواريخ الأحداث: | Date Created: 20170118 Date Completed: 20171227 Latest Revision: 20181113 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC5516406 |
| DOI: | 10.1159/000453610 |
| PMID: | 28095373 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1421-9832 |
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| DOI: | 10.1159/000453610 |