دورية أكاديمية
Expression of NMDA receptor and microRNA-219 in rats submitted to cerebral ischemia associated with alcoholism.
| العنوان: | Expression of NMDA receptor and microRNA-219 in rats submitted to cerebral ischemia associated with alcoholism. |
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| المؤلفون: | Silva CI; Universidade de São Paulo, Departamento de Cirurgia e Anatomia, Ribeirão Preto SP, Brasil., Novais PC; Universidade de Marília, Departamento de Odontologia, Marília SP, Brasil., Rodrigues AR; Universidade de São Paulo, Departamento de Cirurgia e Anatomia, Ribeirão Preto SP, Brasil., Carvalho CA; Universidade Federal de Alagoas, Instituto de Ciências Biológicas e da Saúde, Maceió AL, Brasil., Colli BO; Universidade de São Paulo, Departamento de Cirurgia e Anatomia, Ribeirão Preto SP, Brasil., Carlotti CG Jr; Universidade de São Paulo, Departamento de Cirurgia e Anatomia, Ribeirão Preto SP, Brasil., Tirapelli LF; Universidade de São Paulo, Departamento de Cirurgia e Anatomia, Ribeirão Preto SP, Brasil., Tirapelli DP; Universidade de São Paulo, Departamento de Cirurgia e Anatomia, Ribeirão Preto SP, Brasil. |
| المصدر: | Arquivos de neuro-psiquiatria [Arq Neuropsiquiatr] 2017 Jan; Vol. 75 (1), pp. 30-35. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Thieme Country of Publication: Germany NLM ID: 0125444 Publication Model: Print Cited Medium: Internet ISSN: 1678-4227 (Electronic) Linking ISSN: 0004282X NLM ISO Abbreviation: Arq Neuropsiquiatr Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2022- : [Stuttgart] : Thieme Original Publication: São Paulo. |
| مواضيع طبية MeSH: | Alcoholism/*complications , Brain Ischemia/*metabolism , MicroRNAs/*metabolism , Receptors, N-Methyl-D-Aspartate/*metabolism, Animals ; Brain Ischemia/etiology ; Disease Models, Animal ; Immunohistochemistry ; Male ; Rats ; Rats, Wistar |
| مستخلص: | Objective:: To evaluate the microRNA-219 and NMDA expression in brain tissue and blood of animals subjected to cerebral ischemia associated with alcoholism. Methods:: Fifty Wistar rats were divided into groups: control, sham, ischemic, alcoholic, and ischemic plus alcoholic. The expression of microRNA-219 and NMDA were analyzed by real-time PCR. Results:: When compared to the control group, the microRNA-219 in brain tissue was less expressed in the ischemic, alcoholic, and ischemic plus alcoholic groups. In the blood, this microRNA had lower expression in alcoholic and ischemic plus alcoholic groups. In the brain tissue the NMDA gene expression was greater in the ischemic, alcoholic, and ischemic plus alcoholic groups. Conclusion:: A possible modulation of NMDA by microRNA-219 was observed with an inverse correlation between them. |
| المشرفين على المادة: | 0 (MIRN219 microRNA, rat) 0 (MicroRNAs) 0 (Receptors, N-Methyl-D-Aspartate) |
| تواريخ الأحداث: | Date Created: 20170119 Date Completed: 20170809 Latest Revision: 20220310 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1590/0004-282X20160188 |
| PMID: | 28099560 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1678-4227 |
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| DOI: | 10.1590/0004-282X20160188 |