دورية أكاديمية
أعرض في EDS

Morphine Pharmacodynamics in Mechanically Ventilated Preterm Neonates Undergoing Endotracheal Suctioning.

التفاصيل البيبلوغرافية
العنوان: Morphine Pharmacodynamics in Mechanically Ventilated Preterm Neonates Undergoing Endotracheal Suctioning.
المؤلفون: Välitalo PA; Division of Pharmacology, Leiden University, Leiden, The Netherlands., Krekels EH; Division of Pharmacology, Leiden University, Leiden, The Netherlands., van Dijk M; Intensive Care and Department of Pediatric Surgery Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands.; Department of Pediatrics, Division of Neonatology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands., Simons S; Department of Pediatrics, Division of Neonatology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands., Tibboel D; Intensive Care and Department of Pediatric Surgery Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands., Knibbe CA; Division of Pharmacology, Leiden University, Leiden, The Netherlands.; Intensive Care and Department of Pediatric Surgery Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands.; Department of Clinical Pharmacy, St Antonius Hospital, Nieuwegein, The Netherlands.
المصدر: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2017 Apr; Vol. 6 (4), pp. 239-248. Date of Electronic Publication: 2017 Jan 21.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 101580011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2163-8306 (Electronic) Linking ISSN: 21638306 NLM ISO Abbreviation: CPT Pharmacometrics Syst Pharmacol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2015- : Hoboken, NJ : Wiley
Original Publication: New York, NY : Nature Pub. Group
مواضيع طبية MeSH: Analgesics, Opioid/*pharmacokinetics , Intubation, Intratracheal/*methods , Morphine/*pharmacokinetics , Pain/*drug therapy , Respiration, Artificial/*adverse effects , Respiration, Artificial/*methods, Analgesics, Opioid/administration & dosage ; Humans ; Infant, Newborn ; Infant, Premature ; Intubation, Intratracheal/adverse effects ; Morphine/administration & dosage ; Pain/etiology ; Pain/metabolism ; Pain Measurement ; Randomized Controlled Trials as Topic ; Treatment Outcome
مستخلص: To date, morphine pharmacokinetics (PKs) are well quantified in neonates, but results about its efficacy are ambiguous. This work presents an analysis of a previously published study on pain measurements in mechanically ventilated preterm neonates who received either morphine or placebo to improve comfort during invasive ventilation. The research question was whether morphine reduces the pain associated with endotracheal or nasal suctioning before, during, and after suctioning. Because these neonates cannot verbalize their pain levels, pain was assessed on the basis of several validated pain measurement instruments (i.e., COMFORT-B, preterm infant pain profile [PIPP], Neonatal Infant Pain Scale (NIPS), and visual analogue scale (VAS)). The item response theory (IRT) was used to analyze the data in order for us to handle the data from multiple-item pain scores. The analysis showed an intra-individual relationship between morphine concentrations and pain reduction, as measured by COMFORT-B and VAS. However, the small magnitude of the morphine effect was not considered clinically relevant for this intervention in preterm neonates.
(© 2017 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.)
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المشرفين على المادة: 0 (Analgesics, Opioid)
76I7G6D29C (Morphine)
تواريخ الأحداث: Date Created: 20170122 Date Completed: 20170710 Latest Revision: 20181113
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC5397563
DOI: 10.1002/psp4.12156
PMID: 28109060
قاعدة البيانات: MEDLINE
الوصف
تدمد:2163-8306
DOI:10.1002/psp4.12156