دورية أكاديمية
أعرض في EDS

Targeting β-amyloid plaques and oligomers: development of near-IR fluorescence imaging probes.

التفاصيل البيبلوغرافية
العنوان: Targeting β-amyloid plaques and oligomers: development of near-IR fluorescence imaging probes.
المؤلفون: Liu H; Jiangsu Key Laboratory of Drug Design & Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China., Yang J; Jiangsu Key Laboratory of Drug Design & Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.; Molecular Imaging Laboratory, Massachusetts General Hospital/Massachusetts Institute of Technology/Harvard Medical School Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA 02129, USA., Wang L; Jiangsu Key Laboratory of Drug Design & Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China., Xu Y; Jiangsu Key Laboratory of Drug Design & Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China., Zhang S; Jiangsu Key Laboratory of Drug Design & Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China., Lv J; Jiangsu Key Laboratory of Drug Design & Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China., Ran C; Molecular Imaging Laboratory, Massachusetts General Hospital/Massachusetts Institute of Technology/Harvard Medical School Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA 02129, USA., Li Y; Jiangsu Key Laboratory of Drug Design & Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
المصدر: Future medicinal chemistry [Future Med Chem] 2017 Feb; Vol. 9 (2), pp. 179-198. Date of Electronic Publication: 2017 Jan 27.
نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Future Science Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Future Science, 2009-
مواضيع طبية MeSH: Alzheimer Disease/*diagnosis , Alzheimer Disease/*metabolism , Amyloid beta-Peptides/*analysis , Fluorescent Dyes/*analysis , Fluorescent Dyes/*chemistry, Amyloid beta-Peptides/metabolism ; Binding Sites ; Fluorescent Dyes/chemical synthesis ; Humans
مستخلص: Evidence indicated that shifting treatment to a presymptomatic stage may produce significant benefits to prevent/alleviate the progression of Alzheimer's disease (AD); in particular, early incorporation of noninvasive imaging and biomarker testing will be significantly beneficial for AD drug development. Based on amyloid cascade hypothesis and its revised version, both β-amyloid deposition and soluble oligomeric species could be good diagnostic biomarkers for AD. Near-IR fluorescence (NIRF) imaging, which so far is limited to animal studies, is a promising method for its incomparable advantages such as low cost, high-throughput and easy operation. This review focuses on recent reported NIRF probes that showed excellent binding to plaques and oligomers. We hope that this review will shed light on the future of NIRF probes' discovery.
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معلومات مُعتمدة: K25 AG036760 United States AG NIA NIH HHS; R03 AG050038 United States AG NIA NIH HHS; R21 AG050158 United States AG NIA NIH HHS; S10 RR025504 United States RR NCRR NIH HHS
فهرسة مساهمة: Keywords: Alzheimer's disease; amyloid cascade hypothesis; near-IR fluorescence imaging
المشرفين على المادة: 0 (Amyloid beta-Peptides)
0 (Fluorescent Dyes)
تواريخ الأحداث: Date Created: 20170128 Date Completed: 20170814 Latest Revision: 20181113
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6040043
DOI: 10.4155/fmc-2016-0185
PMID: 28127995
قاعدة البيانات: MEDLINE
الوصف
تدمد:1756-8927
DOI:10.4155/fmc-2016-0185