دورية أكاديمية
أعرض في EDS

Prevalent neuropathy in a cohort of HIV-infected Kenyan sex workers using antiretroviral drugs.

التفاصيل البيبلوغرافية
العنوان: Prevalent neuropathy in a cohort of HIV-infected Kenyan sex workers using antiretroviral drugs.
المؤلفون: Ndakala FN; University of Nairobi, Institute of Tropical and Infectious Diseases, Directorate of Research Management & Development, State Department of Science & Technology, Nairobi, Kenya; University of Nairobi, Institute of Tropical and Infectious Diseases, University of Manitoba, College of Medicine, Department of Medical Microbiology, Winnipeg, Manitoba, Canada., Oyugi JO; University of Nairobi, Institute of Tropical and Infectious Diseases, University of Manitoba, College of Medicine, Department of Medical Microbiology, Winnipeg, Manitoba, Canada., Oluka MN; University of Nairobi, College of Health Sciences, School of Pharmacy, Nairobi, Kenya., Kimani J; University of Manitoba, College of Medicine, Department of Medical Microbiology, Winnipeg, Manitoba, Canada., Jablonka A; Clinical Immunology and Rheumatology, Hannover Medical School, Germany and German Centre for Infection Research, Germany., Behrens GM; Clinical Immunology and Rheumatology, Hannover Medical School, Germany and German Centre for Infection Research, Germany.
المصدر: The Pan African medical journal [Pan Afr Med J] 2016 Sep 20; Vol. 25, pp. 14. Date of Electronic Publication: 2016 Sep 20 (Print Publication: 2016).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: African Field Epidemiology Network Country of Publication: Uganda NLM ID: 101517926 Publication Model: eCollection Cited Medium: Internet ISSN: 1937-8688 (Electronic) NLM ISO Abbreviation: Pan Afr Med J Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Kampala, Uganda : African Field Epidemiology Network
مواضيع طبية MeSH: Sex Workers*, Anti-HIV Agents/*administration & dosage , HIV Infections/*drug therapy , Polyneuropathies/*epidemiology, Adult ; Age Factors ; Anti-HIV Agents/adverse effects ; Female ; Humans ; Kenya/epidemiology ; Male ; Middle Aged ; Polyneuropathies/etiology ; Prevalence ; Retrospective Studies ; Risk Factors ; Stavudine/administration & dosage ; Stavudine/adverse effects ; Tenofovir/administration & dosage ; Tenofovir/adverse effects ; Zidovudine/administration & dosage ; Zidovudine/adverse effects
مستخلص: Introduction: Several risk factors including stavudine and age have been strongly associated with polyneuropathy. However, conflicting data exist on height as an independent risk factor in polyneuropathy. The objective of this study is to exclude height as an independent polyneuropathy risk factor in a cohort of human immunodeficiency virus (HIV)-infected Kenyan sex workers.
Methods: This was an analysis of prospectively collected data of treatment-naive subjects initiating either stavudine or tenofovir diphosphate fumarate or zidovudine-based antiretroviral therapy (ART) regimens from January 2008 to August 2012. Polyneuropathy was characterised as burning sensation, numbness, or dysesthesia. The study used arithmetic means of weight (kg) and height (cm) measured in duplicates using calibrated scales.
Results: After exclusion of duplicate data sets and un-confirmed cases of polyneuropathy, the study identified 212 patients without polyneuropathy, 14 pre-ART and 94 post-ART related polyneuropathy cases. Polyneuropathy cases were older but did not differ in demographic, clinical and laboratory parameters at baseline. There was a significant difference in first-line ART regimens with more patients on tenofovir disoproxil fumarate in the post-ART group (p=0.017).
Conclusion: Polyneuropathy is a common disorder among HIV-infected Kenyan sex workers. These data cannot support the postulated increased risk by height after matching for gender and ART duration. Though stavudine is associated with polyneuropathy, in this study many patients previously not exposed to stavudine developed polyneuropathy. This suggests the involvement of unknown risk factors such as genetic and metabolite differences in the development of polyneuropathy.
Competing Interests: The authors declare no competing interest.
References: AIDS. 2002 Oct 18;16(15):2013-8. (PMID: 12370499)
Afr Health Sci. 2014 Jun;14(2):460-7. (PMID: 25320598)
BMC Public Health. 2014 Dec 19;14:1306. (PMID: 25526665)
Am J Trop Med Hyg. 2010 Sep;83(3):565-70. (PMID: 20810821)
Neurology. 2009 Jan 13;72(2):185-92. (PMID: 19056666)
Am J Phys Anthropol. 2006 May;130(1):135-41. (PMID: 16345070)
AIDS Res Hum Retroviruses. 2008 Oct;24(10):1281-4. (PMID: 18834321)
AIDS. 2011 Apr 24;25(7):919-28. (PMID: 21330902)
Neurology. 2009 Jul 28;73(4):315-20. (PMID: 19636052)
AIDS Res Ther. 2012 Nov 26;9(1):35. (PMID: 23181417)
AIDS. 2000 Mar 31;14(5):615. (PMID: 10780724)
Neurology. 1999 Feb;52(3):607-13. (PMID: 10025796)
J Acquir Immune Defic Syndr. 2007 Jul 1;45(3):304-10. (PMID: 17414931)
HIV Med. 2007 Sep;8(6):367-73. (PMID: 17661844)
Clin Infect Dis. 2011 Sep;53(5):490-6. (PMID: 21844033)
AIDS. 2000 Feb 18;14(3):273-8. (PMID: 10716503)
Brain. 2004 Jul;127(Pt 7):1606-15. (PMID: 15128618)
Muscle Nerve. 2010 May;41(5):599-606. (PMID: 20229576)
Arch Neurol. 1999 Jan;56(1):84-9. (PMID: 9923765)
Drugs. 2000 Jun;59(6):1251-60. (PMID: 10882161)
CMAJ. 2006 Jan 31;174(3):319-23. (PMID: 16446472)
Neurology. 2006 Mar 28;66(6):867-73. (PMID: 16567704)
AIDS. 2005 Sep 2;19(13):1341-9. (PMID: 16103764)
World Health Organ Tech Rep Ser. 1995;854:1-452. (PMID: 8594834)
AIDS. 2011 Jan 14;25(2):F1-6. (PMID: 21150557)
Curr Pain Headache Rep. 2012 Jun;16(3):226-36. (PMID: 22367397)
J Pain Symptom Manage. 2011 Apr;41(4):700-6. (PMID: 21145196)
J Neurovirol. 2002 Dec;8 Suppl 2:115-21. (PMID: 12491162)
Pain. 2016 Aug;157(8):1599-1606. (PMID: 27115670)
Arch Neurol. 2010 May;67(5):552-8. (PMID: 20457954)
Diabetes Res Clin Pract. 2002 Jul;57(1):45-51. (PMID: 12007729)
Curr HIV/AIDS Rep. 2007 Aug;4(3):114-8. (PMID: 17883996)
PLoS One. 2010 Dec 08;5(12):e14256. (PMID: 21170387)
Am J Epidemiol. 2006 Nov 1;164(9):873-80. (PMID: 16905646)
AIDS. 2002 Nov 8;16(16):2105-17. (PMID: 12409731)
Clin Infect Dis. 2009 Jun 1;48(11):1617-23. (PMID: 19385733)
Ann Intern Med. 1996 Apr 1;124(7):654-63. (PMID: 8607594)
Expert Opin Pharmacother. 2013 Jun;14(8):1055-64. (PMID: 23510448)
Bull Soc Pathol Exot. 2008 Feb;101(1):11-3. (PMID: 18431998)
HIV AIDS (Auckl). 2013;5:1-17. (PMID: 23326204)
Diabetes Care. 2004 Jul;27(7):1591-7. (PMID: 15220233)
Ann Neurol. 2001 Aug;50(2):157-62. (PMID: 11506397)
AIDS. 2002 Oct 18;16(15):2043-7. (PMID: 12370503)
J Acquir Immune Defic Syndr. 2007 Apr 1;44(4):456-62. (PMID: 17279048)
Curr Opin Neurol. 2006 Oct;19(5):446-50. (PMID: 16969153)
Lancet. 1996 Nov 16;348(9038):1347-51. (PMID: 8918278)
J Neurovirol. 2012 Jun;18(3):162-71. (PMID: 22528477)
فهرسة مساهمة: Keywords: Antiretroviral therapy; height; polyneuropathy; resource-limited settings; risk factor; sex workers; stavudine; tenofovir disoproxil fumarate
المشرفين على المادة: 0 (Anti-HIV Agents)
4B9XT59T7S (Zidovudine)
99YXE507IL (Tenofovir)
BO9LE4QFZF (Stavudine)
تواريخ الأحداث: Date Created: 20170204 Date Completed: 20170322 Latest Revision: 20231112
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC5268751
DOI: 10.11604/pamj.2016.25.14.9699
PMID: 28154706
قاعدة البيانات: MEDLINE
الوصف
تدمد:1937-8688
DOI:10.11604/pamj.2016.25.14.9699