دورية أكاديمية
Prevalent neuropathy in a cohort of HIV-infected Kenyan sex workers using antiretroviral drugs.
العنوان: | Prevalent neuropathy in a cohort of HIV-infected Kenyan sex workers using antiretroviral drugs. |
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المؤلفون: | Ndakala FN; University of Nairobi, Institute of Tropical and Infectious Diseases, Directorate of Research Management & Development, State Department of Science & Technology, Nairobi, Kenya; University of Nairobi, Institute of Tropical and Infectious Diseases, University of Manitoba, College of Medicine, Department of Medical Microbiology, Winnipeg, Manitoba, Canada., Oyugi JO; University of Nairobi, Institute of Tropical and Infectious Diseases, University of Manitoba, College of Medicine, Department of Medical Microbiology, Winnipeg, Manitoba, Canada., Oluka MN; University of Nairobi, College of Health Sciences, School of Pharmacy, Nairobi, Kenya., Kimani J; University of Manitoba, College of Medicine, Department of Medical Microbiology, Winnipeg, Manitoba, Canada., Jablonka A; Clinical Immunology and Rheumatology, Hannover Medical School, Germany and German Centre for Infection Research, Germany., Behrens GM; Clinical Immunology and Rheumatology, Hannover Medical School, Germany and German Centre for Infection Research, Germany. |
المصدر: | The Pan African medical journal [Pan Afr Med J] 2016 Sep 20; Vol. 25, pp. 14. Date of Electronic Publication: 2016 Sep 20 (Print Publication: 2016). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: African Field Epidemiology Network Country of Publication: Uganda NLM ID: 101517926 Publication Model: eCollection Cited Medium: Internet ISSN: 1937-8688 (Electronic) NLM ISO Abbreviation: Pan Afr Med J Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Kampala, Uganda : African Field Epidemiology Network |
مواضيع طبية MeSH: | Sex Workers*, Anti-HIV Agents/*administration & dosage , HIV Infections/*drug therapy , Polyneuropathies/*epidemiology, Adult ; Age Factors ; Anti-HIV Agents/adverse effects ; Female ; Humans ; Kenya/epidemiology ; Male ; Middle Aged ; Polyneuropathies/etiology ; Prevalence ; Retrospective Studies ; Risk Factors ; Stavudine/administration & dosage ; Stavudine/adverse effects ; Tenofovir/administration & dosage ; Tenofovir/adverse effects ; Zidovudine/administration & dosage ; Zidovudine/adverse effects |
مستخلص: | Introduction: Several risk factors including stavudine and age have been strongly associated with polyneuropathy. However, conflicting data exist on height as an independent risk factor in polyneuropathy. The objective of this study is to exclude height as an independent polyneuropathy risk factor in a cohort of human immunodeficiency virus (HIV)-infected Kenyan sex workers. Methods: This was an analysis of prospectively collected data of treatment-naive subjects initiating either stavudine or tenofovir diphosphate fumarate or zidovudine-based antiretroviral therapy (ART) regimens from January 2008 to August 2012. Polyneuropathy was characterised as burning sensation, numbness, or dysesthesia. The study used arithmetic means of weight (kg) and height (cm) measured in duplicates using calibrated scales. Results: After exclusion of duplicate data sets and un-confirmed cases of polyneuropathy, the study identified 212 patients without polyneuropathy, 14 pre-ART and 94 post-ART related polyneuropathy cases. Polyneuropathy cases were older but did not differ in demographic, clinical and laboratory parameters at baseline. There was a significant difference in first-line ART regimens with more patients on tenofovir disoproxil fumarate in the post-ART group (p=0.017). Conclusion: Polyneuropathy is a common disorder among HIV-infected Kenyan sex workers. These data cannot support the postulated increased risk by height after matching for gender and ART duration. Though stavudine is associated with polyneuropathy, in this study many patients previously not exposed to stavudine developed polyneuropathy. This suggests the involvement of unknown risk factors such as genetic and metabolite differences in the development of polyneuropathy. Competing Interests: The authors declare no competing interest. |
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فهرسة مساهمة: | Keywords: Antiretroviral therapy; height; polyneuropathy; resource-limited settings; risk factor; sex workers; stavudine; tenofovir disoproxil fumarate |
المشرفين على المادة: | 0 (Anti-HIV Agents) 4B9XT59T7S (Zidovudine) 99YXE507IL (Tenofovir) BO9LE4QFZF (Stavudine) |
تواريخ الأحداث: | Date Created: 20170204 Date Completed: 20170322 Latest Revision: 20231112 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC5268751 |
DOI: | 10.11604/pamj.2016.25.14.9699 |
PMID: | 28154706 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1937-8688 |
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DOI: | 10.11604/pamj.2016.25.14.9699 |