دورية أكاديمية
أعرض في EDS

Validation of 3D volumetric-based renal function prediction calculator for nephron sparing surgery.

التفاصيل البيبلوغرافية
العنوان: Validation of 3D volumetric-based renal function prediction calculator for nephron sparing surgery.
المؤلفون: Corradi R; Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Kabra A; Department of Urology, University of Texas Health Science Center San Antonio, 7703, Floyd Curl Drive, San Antonio, TX, USA., Suarez M; Department of Urology, University of California-Irvine, Irvine, CA, USA., Oppenheimer J; Department of Urology, University of Texas Health Science Center San Antonio, 7703, Floyd Curl Drive, San Antonio, TX, USA., Okhunov Z; Department of Urology, University of California-Irvine, Irvine, CA, USA., White H; Department of Radiology, University of Texas Health Science Center San Antonio, San Antonio, TX, USA., Nougaret S; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; INSERM, U1194, Institut de Recherche en Cancérologie de Montpellier (IRCM), Montpellier, France.; Service de Radiologie, Institut Régional du Cancer de Montpellier, Montpellier, France., Vargas HA; Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Landman J; Department of Urology, University of California-Irvine, Irvine, CA, USA., Coleman J; Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Liss MA; Department of Urology, University of Texas Health Science Center San Antonio, 7703, Floyd Curl Drive, San Antonio, TX, USA. liss@uthscsa.edu.
المصدر: International urology and nephrology [Int Urol Nephrol] 2017 Apr; Vol. 49 (4), pp. 615-621. Date of Electronic Publication: 2017 Feb 04.
نوع المنشور: Journal Article; Multicenter Study; Validation Study
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Netherlands NLM ID: 0262521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2584 (Electronic) Linking ISSN: 03011623 NLM ISO Abbreviation: Int Urol Nephrol Subsets: MEDLINE
أسماء مطبوعة: Publication: Amsterdam : Springer
Original Publication: Budapest, Akademiai Kiadó
مواضيع طبية MeSH: Glomerular Filtration Rate*, Carcinoma, Renal Cell/*diagnostic imaging , Carcinoma, Renal Cell/*surgery , Kidney/*physiopathology , Kidney Neoplasms/*diagnostic imaging , Kidney Neoplasms/*surgery, Aged ; Carcinoma, Renal Cell/pathology ; Clinical Decision-Making ; Female ; Humans ; Imaging, Three-Dimensional ; Internet ; Kidney Neoplasms/pathology ; Male ; Middle Aged ; Multidetector Computed Tomography ; Nephrectomy/methods ; Nephrons/surgery ; Organ Sparing Treatments ; Postoperative Period ; Predictive Value of Tests ; Preoperative Period ; Retrospective Studies ; Software ; Tumor Burden
مستخلص: Objective: To evaluate a recently published volume-based renal function prediction calculator intended to be used in small renal mass surgical counseling.
Methods: Retrospective data collection included three-dimensional calculation of renal mass and parenchyma of patients who have undergone extirpative therapy. The predicted glomerular filtration rate (GFR) was calculated using the online calculator. The predicted GFR was compared with the actual 6-month GFR. The Pearson correlation coefficient, paired t test and root-mean-square error (RMSE) are utilized for statistical analysis.
Results: After institutional review board approval, three institutions provided data for analysis. After patients with renal mass size >300 cc, renal size >400 cc or preoperative CKD ≥stage 3 had been excluded, we retrospectively analyzed data from 136 patients. The median mass volume was 22.2 cc (IQR 7-49). In multiple linear regression analysis, the most significant variables predicting postoperative GFR were partial versus radical nephrectomy and preoperative GFR with an overall R 2 of .68 (F = 26.13, P < .001). The predicted GFR was 75.4 mL/min/1.73 m 2 compared to an actual GFR of 70.7 mL/min/1.73 m 2 (P < .001, paired t test). The predicted GFR was highly correlated with the actual postoperative GFR at 6 months (Pearson correlation, r = .65, P < .001). RMSE of the validation cohort was 16.87.
Conclusions: The predictive tool to determine renal function benefit of nephron sparing surgery compared to radical nephrectomy online calculator effectively predicts GFR and could potentially be used to help urologists and patients discuss renal function prior to extirpative renal surgery.
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معلومات مُعتمدة: P30 CA008748 United States CA NCI NIH HHS
فهرسة مساهمة: Keywords: Calculator; Chronic kidney disease; Partial nephrectomy; Renal cancer; Renal mass
تواريخ الأحداث: Date Created: 20170206 Date Completed: 20171024 Latest Revision: 20191210
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5589462
DOI: 10.1007/s11255-017-1525-y
PMID: 28161843
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-2584
DOI:10.1007/s11255-017-1525-y