دورية أكاديمية
Levels of l-arginine and l-citrulline in patients with erectile dysfunction of different etiology.
| العنوان: | Levels of l-arginine and l-citrulline in patients with erectile dysfunction of different etiology. |
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| المؤلفون: | Barassi A; Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milano, Italy., Corsi Romanelli MM; Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milano, Italy.; Unità Operativa Medicina di Laboratorio -1 Patologia Clinica, IRCCS Policlinico San Donato, San Donato Milanese, Milano, Italy., Pezzilli R; Dipartimento di Malattie dell'Apparato Digerente e Medicina Interna, Ospedale Sant'Orsola-Malpighi, Alma Mater Studiorum, Università degli Studi di Bologna, Bologna, Italy., Damele CA; Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milano, Italy., Vaccalluzzo L; ISES - Istituto per la Sterilità e la Sessualità, Milano, Italy., Goi G; Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Università degli Studi di Milano, Milano, Italy., Papini N; Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, Milano, Italy., Colpi GM; ISES - Istituto per la Sterilità e la Sessualità, Milano, Italy., Massaccesi L; Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Università degli Studi di Milano, Milano, Italy., Melzi d'Eril GV; Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milano, Italy. |
| المصدر: | Andrology [Andrology] 2017 Mar; Vol. 5 (2), pp. 256-261. Date of Electronic Publication: 2017 Feb 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101585129 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-2927 (Electronic) Linking ISSN: 20472919 NLM ISO Abbreviation: Andrology Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford : Wiley-Blackwell, 2013- |
| مواضيع طبية MeSH: | Arginine/*blood , Citrulline/*blood , Erectile Dysfunction/*blood , Penile Erection/*physiology, Adult ; Erectile Dysfunction/diagnostic imaging ; Erectile Dysfunction/etiology ; Humans ; Male ; Middle Aged ; Severity of Illness Index ; Ultrasonography, Doppler, Color |
| مستخلص: | Nitric oxide is a physiologic signal essential to penile erection. l-citrulline (l-Cit) is converted into l-arginine (l-Arg), the precursor from which nitric oxide is generated. The level of l-Arg and l-Cit in the field of male sexual function remains relatively underexplored. The aim of the study was to evaluate the level of serum l-Arg and of l-Cit in a group of patients with erectile dysfunction. Diagnosis and severity of erectile dysfunction was based on the IIEF-5 and its etiology was classified as arteriogenic (A-ED), borderline (BL-ED), and non-arteriogenic (NA-ED) with penile echo-color-Doppler in basal condition and after intracaversous injection of prostaglandin E1. Serum l-Arg and l-Cit concentrations were measured by a cation-exchange chromatography system. l-Arg and l-Cit levels of men with A-ED were compared with those of male with BL-ED and NA-ED. Median level of l-Arg and l-Cit in 122 erectile dysfunction patients (41 A-ED, 23 ED-BL, 58 NA-ED) was 82.7 and 35.4 μmol/L, respectively. l-Arg and l-Cit levels in control patients were not significantly different (p = 0.233 and p = 0.561, respectively) than in total erectile dysfunction patients. l-Arg and l-Cit levels in control patients were significantly higher (p < 0.001 and p < 0.018, respectively) than in A-ED patients, but no difference (p > 0.50) was observed in controls and in both BL-ED and NA-ED patients. Patients with severe/complete-erectile dysfunction (IIEF-5 < 10) had l-Arg or l-Cit level significantly lower (-17%, p < 0.03; -13%, p < 0.04) and were more frequent (p < 0.01 and p < 0.04) under the respective median level (82.7 and 35.4 μmol/L) than those with mild-erectile dysfunction (IIEF-5 = 16-20). l-Arg and l-Cit levels in A-ED were significantly lower (p < 0.007 and p < 0.001, respectively) than in NA-ED patients. Penile echo-color-Doppler revealed that A-ED (peak systolic velocity ≤ 25 cm/sec) was more frequent in men with l-Arg under 82.7 μmol/L or l-Cit under 35.4 μmol/L and in the same population, the median peak systolic velocity values were lower in l-Arg deficient (29 vs. 35; p < 0.04) and also in l-Cit deficient (31 vs. 33, p > 0.3) but without reaching the statistical significance. Our study shows that a significant proportion of erectile dysfunction patients have low l-Arg or l-Cit level and that this condition is more frequent in patients with arteriogenic etiology. Low levels of these nitric oxide synthase substrates might increase the erectile dysfunction risk by reducing the concentration of nitric oxide. (© 2017 American Society of Andrology and European Academy of Andrology.) |
| فهرسة مساهمة: | Keywords: erectile dysfunction; l-arginine; l-citrulline |
| المشرفين على المادة: | 29VT07BGDA (Citrulline) 94ZLA3W45F (Arginine) |
| تواريخ الأحداث: | Date Created: 20170209 Date Completed: 20171207 Latest Revision: 20180226 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1111/andr.12293 |
| PMID: | 28178400 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2047-2927 |
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| DOI: | 10.1111/andr.12293 |