دورية أكاديمية
أعرض في EDS

Genital-Systemic Chemokine Gradients and the Risk of HIV Acquisition in Women.

التفاصيل البيبلوغرافية
العنوان: Genital-Systemic Chemokine Gradients and the Risk of HIV Acquisition in Women.
المؤلفون: Liebenberg LJ; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa; †Department of Medical Microbiology, University of KwaZulu-Natal, Durban, South Africa; ‡Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa; §Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA; ‖Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI; ¶Department of Epidemiology, Columbia University, New York City, NY; and #National Health Laboratory Service, Johannesburg, South Africa., Masson L, Arnold KB, Mckinnon LR, Werner L, Proctor E, Archary D, Mansoor LE, Lauffenburger DA, Abdool Karim Q, Abdool Karim SS, Passmore JS
المصدر: Journal of acquired immune deficiency syndromes (1999) [J Acquir Immune Defic Syndr] 2017 Mar 01; Vol. 74 (3), pp. 318-325.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins, Inc Country of Publication: United States NLM ID: 100892005 Publication Model: Print Cited Medium: Internet ISSN: 1944-7884 (Electronic) Linking ISSN: 15254135 NLM ISO Abbreviation: J Acquir Immune Defic Syndr Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Hagerstown, MD : Lippincott Williams & Wilkins, Inc., c1999-
مواضيع طبية MeSH: Immunity, Mucosal*, Chemokines/*analysis , Genitalia, Female/*immunology , HIV Infections/*epidemiology, Adult ; Female ; Humans ; Risk Assessment ; Young Adult
مستخلص: Background: Mucosal and systemic immune mediators have been independently associated with HIV acquisition risk, but the relationship between compartments remains unclear.
Methods: To address this, the concentrations of 12 cytokines were compared in matched plasma and cervicovaginal lavages (CVLs) from 57 HIV-positive women before their acquisition of HIV (cases) and 50 women who remained uninfected (controls) during the CAPRISA 004 trial.
Results: Although genital IP-10 concentrations were significantly higher in cases, plasma IP-10 concentrations were inversely associated with HIV risk. Comparing differences in mucosal and systemic cytokine concentrations between cases and controls, mucosa-biased gradients indicating higher cervicovaginal lavage relative to plasma concentrations were observed for all 5 chemokines in the panel. Four were significantly associated with HIV acquisition, including IP-10 (odds ratio [OR] 1.73, 95% confidence interval [CI]: 1.27 to 2.36), macrophage inflammatory protein-1β (OR 1.72, 95% CI: 1.23 to 2.40), interleukin (IL)-8 (OR 1.50, 95% CI: 1.09 to 2.05), and monocyte chemotactic protein-1 (OR 1.36, 95% CI: 1.01 to 1.83). None of the other 7 cytokines tested predicted HIV risk. Decision tree analyses confirmed this association, with gradients of IP-10, IL-8, and granulocyte-macrophage colony-stimulating factor concentrations correctly classifying 77% of HIV outcomes.
Conclusions: Our findings suggest that mucosa-biased gradients of IP-10, macrophage inflammatory protein-1β, IL-8, and monocyte chemotactic protein-1 are associated with an increased risk of HIV infection.
Competing Interests: The authors have no conflicts of interest to disclose.
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المشرفين على المادة: 0 (Chemokines)
تواريخ الأحداث: Date Created: 20170211 Date Completed: 20170612 Latest Revision: 20200930
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5305292
DOI: 10.1097/QAI.0000000000001218
PMID: 28187085
قاعدة البيانات: MEDLINE
الوصف
تدمد:1944-7884
DOI:10.1097/QAI.0000000000001218