دورية أكاديمية
أعرض في EDS

FAM13A is associated with non-small cell lung cancer (NSCLC) progression and controls tumor cell proliferation and survival.

التفاصيل البيبلوغرافية
العنوان: FAM13A is associated with non-small cell lung cancer (NSCLC) progression and controls tumor cell proliferation and survival.
المؤلفون: Eisenhut F; Department of Molecular Pneumology, Friedrich-Alexander-Universität Erlangen-Nürnberg , Erlangen, Germany., Heim L; Department of Molecular Pneumology, Friedrich-Alexander-Universität Erlangen-Nürnberg , Erlangen, Germany., Trump S; Department of Molecular Pneumology, Friedrich-Alexander-Universität Erlangen-Nürnberg , Erlangen, Germany., Mittler S; Department of Molecular Pneumology, Friedrich-Alexander-Universität Erlangen-Nürnberg , Erlangen, Germany., Sopel N; Department of Molecular Pneumology, Friedrich-Alexander-Universität Erlangen-Nürnberg , Erlangen, Germany., Andreev K; Department of Molecular Pneumology, Friedrich-Alexander-Universität Erlangen-Nürnberg , Erlangen, Germany., Ferrazzi F; Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg , Erlangen, Germany., Ekici AB; Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg , Erlangen, Germany., Rieker R; Institute of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg , Erlangen, Germany., Springel R; Department of Molecular Pneumology, Friedrich-Alexander-Universität Erlangen-Nürnberg , Erlangen, Germany., Assmann VL; Department of Immune Modulation, Department of Dermatology, Friedrich-Alexander-Universität Erlangen-Nürnberg , Erlangen, Germany., Lechmann M; Department of Immune Modulation, Department of Dermatology, Friedrich-Alexander-Universität Erlangen-Nürnberg , Erlangen, Germany., Koch S; Department of Molecular Pneumology, Friedrich-Alexander-Universität Erlangen-Nürnberg , Erlangen, Germany., Engelhardt M; Department of Molecular Pneumology, Friedrich-Alexander-Universität Erlangen-Nürnberg , Erlangen, Germany., Warnecke C; Department of Medicine 4, Nephrology and Hypertension, Friedrich-Alexander-Universität Erlangen-Nürnberg , Erlangen, Germany., Trufa DI; Department of Thoracic Surgery, Friedrich-Alexander-Universität Erlangen-Nürnberg , Erlangen, Germany., Sirbu H; Department of Thoracic Surgery, Friedrich-Alexander-Universität Erlangen-Nürnberg , Erlangen, Germany., Hartmann A; Institute of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg , Erlangen, Germany., Finotto S; Department of Molecular Pneumology, Friedrich-Alexander-Universität Erlangen-Nürnberg , Erlangen, Germany.
المصدر: Oncoimmunology [Oncoimmunology] 2016 Dec 14; Vol. 6 (1), pp. e1256526. Date of Electronic Publication: 2016 Dec 14 (Print Publication: 2017).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101570526 Publication Model: eCollection Cited Medium: Print ISSN: 2162-4011 (Print) Linking ISSN: 21624011 NLM ISO Abbreviation: Oncoimmunology Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2015- : Philadelphia, PA : Taylor & Francis
Original Publication: Austin, TX : Landes Bioscience
مستخلص: Genome-wide association studies (GWAS) associated Family with sequence similarity 13, member A (FAM13A) with non-small cell lung cancer (NSCLC) occurrence. Here, we found increased numbers of FAM13A protein expressing cells in the tumoral region of lung tissues from a cohort of patients with NSCLC. Moreover, FAM13A inversely correlated with CTLA4 but directly correlated with HIF1α levels in the control region of these patients. Consistently, FAM13A RhoGAP was found to be associated with T cell effector molecules like HIF1α and Tbet and was downregulated in immunosuppressive CD4 + CD25 + Foxp3 + CTLA4 + T cells. TGFβ, a tumor suppressor factor, as well as siRNA to FAM13A, suppressed both isoforms of FAM13A and inhibited tumor cell proliferation. RNA-Seq analysis confirmed this finding. Moreover, siRNA to FAM13A induced TGFβ levels. Finally, in experimental tumor cell migration, FAM13A was induced and TGFβ accelerated this process by inducing cell migration, HIF1α, and the FAM13A RhoGAP isoform. Furthermore, siRNA to FAM13A inhibited tumor cell proliferation and induced cell migration without affecting HIF1α. In conclusion, FAM13A is involved in tumor cell proliferation and downstream of TGFβ and HIF1α, FAM13A RhoGAP is associated with Th1 gene expression and lung tumor cell migration. These findings identify FAM13A as key regulator of NSCLC growth and progression.
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فهرسة مساهمة: Keywords: FAM13A; Non-Small Cell Lung Cancer (NSCLC); TGFβ1; metastasis; proliferation; regulatory T Cells
تواريخ الأحداث: Date Created: 20170216 Latest Revision: 20210112
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5283630
DOI: 10.1080/2162402X.2016.1256526
PMID: 28197372
قاعدة البيانات: MEDLINE
الوصف
تدمد:2162-4011
DOI:10.1080/2162402X.2016.1256526