دورية أكاديمية
Opiate Analgesia Treatment Reduced Early Inflammatory Response After Severe Chest Injuries.
| العنوان: | Opiate Analgesia Treatment Reduced Early Inflammatory Response After Severe Chest Injuries. |
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| المؤلفون: | Krdzalic G; Department of Thoracic Surgery, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina., Musanovic N; Department of Thoracic Surgery, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina., Krdzalic A; Department of Cardio Anesthesia and Intensive Care, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina., Mehmedagic I; Department of Hepatobiliary Surgery, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina., Kesetovic A; Department of Thoracic Surgery, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina. |
| المصدر: | Medical archives (Sarajevo, Bosnia and Herzegovina) [Med Arch] 2016 Dec; Vol. 70 (6), pp. 457-459. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academy of Medical Sciences of Bosnia and Herzegovina Country of Publication: Bosnia and Herzegovina NLM ID: 101635337 Publication Model: Print Cited Medium: Print ISSN: 0350-199X (Print) Linking ISSN: 0350199X NLM ISO Abbreviation: Med Arch Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Sarajevo, Bosnia and Herzegovina : Academy of Medical Sciences of Bosnia and Herzegovina Original Publication: Sarajevo, Bosnia and Herzegovina : Avicena, 2012- |
| مواضيع طبية MeSH: | Analgesia*/methods, Analgesics, Opioid/*therapeutic use , Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use , Dipyrone/*therapeutic use , Thoracic Injuries/*therapy , Tramadol/*therapeutic use, Hospitals, University ; Humans ; Length of Stay ; Prospective Studies ; Treatment Outcome |
| مستخلص: | Background: The frequency of severe chest injuries are increased. Their high morbidity is followed by systemic inflammatory response. The efficacy of pharmacological blockade of the response could prevent complications after chest injures. Aim: The aim of the study was to show an inflammatory response level, its prognostic significant and length of hospital stay after chest injures opiate analgesia treatment. Methods: Sixty patients from Department of Thoracic Surgery with severe chest injures were included in the prospective study. With respect of non opiate or opiate analgesia treatment, the patients were divided in two groups consisted of 30 patients. As a inflammatory markers, serum values of leukocytes, neutrophils, C-reactive protein (CRP) and fibrinogen in three measurements: at the time of admission, 24hours and 48 hours after admission, were followed. Results: Statistically significant differences were found between the examined groups in mean serum values of neutrophils (p=0.026 and p=0.03) in the second and the third measurement, CRP (p=0.05 and 0.25) in the second and the third measurement and leukocytes in the third measurement (p=0.016). 6 patients in group I and 3 in group II had initial stage of pneumonia, 13 patients in group I and 6 in group II had atelectasis and 7 patients from group I and 4 from group II had pleural effusion. The rate of complications was lower in group of patient who were under opiate analgesia treatment but without significant difference. The length of hospital stay for the patients in group I was 7.3±1.15 days and for the patients in group II it was 6.1±0.87 days with statistically significant difference p=0.017. Conclusion: The opiate analgesia in patients with severe chest injures reduced level of early inflammatory response, rate of intra hospital complications and length of hospital stay. Competing Interests: • Conflict of interest: none declared. |
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| فهرسة مساهمة: | Keywords: inflammatory response; opiate analgesia; severe chest injuries |
| المشرفين على المادة: | 0 (Analgesics, Opioid) 0 (Anti-Inflammatory Agents, Non-Steroidal) 39J1LGJ30J (Tramadol) 6429L0L52Y (Dipyrone) |
| تواريخ الأحداث: | Date Created: 20170218 Date Completed: 20180308 Latest Revision: 20181113 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC5292224 |
| DOI: | 10.5455/medarh.2016.70.457-459 |
| PMID: | 28210021 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0350-199X |
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| DOI: | 10.5455/medarh.2016.70.457-459 |