دورية أكاديمية
أعرض في EDS

Seed and peel essential oils obtained from Campomanesia adamantium fruit inhibit inflammatory and pain parameters in rodents.

التفاصيل البيبلوغرافية
العنوان: Seed and peel essential oils obtained from Campomanesia adamantium fruit inhibit inflammatory and pain parameters in rodents.
المؤلفون: Zuntini Viscardi D; College of Exact and Technological Sciences, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., Arrigo JD; College of Exact and Technological Sciences, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., Correia CA; College of Exact and Technological Sciences, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., Kassuya CA; College of Health Sciences, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., Cardoso CA; Course of Chemistry, State University of Mato Grosso do Sul, Dourados, Mato Grosso do Sul, Brazil., Maldonade IR; Brazilian Agricultural Research Agency (Embrapa), Brasília, Federal District, Brazil., Argandoña EJ; College of Food Engineering, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.
المصدر: PloS one [PLoS One] 2017 Feb 21; Vol. 12 (2), pp. e0157107. Date of Electronic Publication: 2017 Feb 21 (Print Publication: 2017).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Analgesics/*pharmacology , Anti-Inflammatory Agents/*pharmacology , Oils, Volatile/*pharmacology , Pimenta/*chemistry, Analgesics/isolation & purification ; Animals ; Anti-Inflammatory Agents/isolation & purification ; Carrageenan/toxicity ; Chemotaxis, Leukocyte/drug effects ; Cold Temperature/adverse effects ; Drug Evaluation, Preclinical ; Edema/drug therapy ; Female ; Formaldehyde/toxicity ; Fruit/chemistry ; Hyperalgesia/drug therapy ; Hyperalgesia/etiology ; Male ; Mice ; Oils, Volatile/isolation & purification ; Oils, Volatile/toxicity ; Pain/chemically induced ; Pain/drug therapy ; Pain/etiology ; Plants, Medicinal/chemistry ; Pleurisy/drug therapy ; Rats ; Rats, Wistar ; Seeds/chemistry
مستخلص: Campomanesia adamantium (Myrtaceae) is popularly known as "gabiroba" and has been used in folk medicine as antirheumatic, antidiarrheal, hypocholesterolemic and anti-inflammatory. This study evaluated the anti-inflammatory and antinociceptive activities and toxicology of essential oils from peel (EOP) and seed (EOS) of C. adamantium fruits in animal models. Different groups were treated with doses of 100 and 300 mg/kg and the inflammatory parameters were evaluated in carrageenan induced paw oedema and leukocyte migration in pleurisy model, while antinociceptive activity was evaluated using formalin method in rodents. The major constituent of EOP and EOS was limonene with 13.07% and 20.89%, respectively. No clinical signs of toxicity have been observed in animals. It was observed a significant decreased (P<0.01) in leukocyte migration at the dose of 300 mg/kg of EOP and EOS, with maximal inhibition of 89±3% for EOP and 80±6% for EOS. Paw oedema was inhibited at all times, and maximal inhibition was at the dose of 100 mg/kg at 2 h after carrageenan injection with 72±2% for EOP and 74±2% for EOS. EOS and EOP also reduced the first and second phases of formalin-induced nociception test. In the first formalin-phase, maximal inhibitions were at 48±5% for EOP and 66±4% for EOS (300 mg/kg). At the inflammatory phase induced by formalin, maximal inhibitions were 72±2% for EOP and 80±2% for EOS at the dose of 100 mg/kg. Seed and peel essential oils from C. adamantium fruit inhibited leukocyte migration, inflammatory and neurogenic pain and oedema suggesting their use as nutraceutical or pharmacological agent.
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المشرفين على المادة: 0 (Analgesics)
0 (Anti-Inflammatory Agents)
0 (Oils, Volatile)
1HG84L3525 (Formaldehyde)
9000-07-1 (Carrageenan)
تواريخ الأحداث: Date Created: 20170222 Date Completed: 20170821 Latest Revision: 20211204
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC5319778
DOI: 10.1371/journal.pone.0157107
PMID: 28222179
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0157107