دورية أكاديمية
Preoperative albumin level is a marker of alveolar echinococcosis recurrence after hepatectomy.
| العنوان: | Preoperative albumin level is a marker of alveolar echinococcosis recurrence after hepatectomy. |
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| المؤلفون: | Joliat GR; Gaëtan-Romain Joliat, Ismail Labgaa, Nicolas Demartines, Nermin Halkic, Department of Visceral Surgery, University Hospital CHUV, 1011 Lausanne, Switzerland., Labgaa I; Gaëtan-Romain Joliat, Ismail Labgaa, Nicolas Demartines, Nermin Halkic, Department of Visceral Surgery, University Hospital CHUV, 1011 Lausanne, Switzerland., Demartines N; Gaëtan-Romain Joliat, Ismail Labgaa, Nicolas Demartines, Nermin Halkic, Department of Visceral Surgery, University Hospital CHUV, 1011 Lausanne, Switzerland., Halkic N; Gaëtan-Romain Joliat, Ismail Labgaa, Nicolas Demartines, Nermin Halkic, Department of Visceral Surgery, University Hospital CHUV, 1011 Lausanne, Switzerland. |
| المصدر: | World journal of gastroenterology [World J Gastroenterol] 2017 Feb 07; Vol. 23 (5), pp. 853-858. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 100883448 Publication Model: Print Cited Medium: Internet ISSN: 2219-2840 (Electronic) Linking ISSN: 10079327 NLM ISO Abbreviation: World J Gastroenterol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2014- : Pleasanton, CA : Baishideng Publishing Group Original Publication: Beijing : WJG Press, c1998- |
| مواضيع طبية MeSH: | Echinococcosis, Hepatic/*blood , Serum Albumin/*metabolism, Aged ; Biomarkers/blood ; Cohort Studies ; Disease-Free Survival ; Echinococcosis ; Echinococcosis, Hepatic/surgery ; Female ; Hepatectomy ; Humans ; Male ; Middle Aged ; Preoperative Period ; Recurrence ; Retrospective Studies ; Risk Factors |
| مستخلص: | Aim: To identify a preoperative blood marker predictive of alveolar echinococcosis (AE) recurrence after hepatectomy. Methods: All consecutive patients who underwent operation for liver AE at the Lausanne University Hospital (CHUV) between January 1992 and December 2015 were included in this retrospective study. Preoperative laboratory values of leukocytes, mean corpuscular volume (MCV), red blood cell distribution width (RDW), thrombocytes, C-reactive protein (CRP) and albumin were collected and analyzed. Univariate and multivariate Cox regression analyses were performed to determine the risk factors for AE recurrence after liver resection. A receiver operating characteristic (ROC) curve was used to define the best discrimination threshold of the blood marker. Moreover, recurrence-free survival curves were calculated using the Kaplan-Meier method. Results: The cohort included 68 adult patients (37 females) with median age of 61 years [interquartile range (IQR): 46-71]. Eight of the patients (12%) presented a recurrence over a median follow-up time of 76 mo (IQR: 34-128). Median time to recurrence was 10 mo (IQR: 6-11). Median preoperative leukocyte, MCV, RDW, thrombocyte and CRP levels were similar between recurrent and non-recurrent cases. Median preoperative albumin level was 43 g/L (IQR: 41-45) for non-recurrent cases and 36 g/L (IQR: 33-42) for recurrent cases ( P = 0.005). The area under the ROC curve for preoperative albumin level to predict recurrence was 0.840 (95%CI: 0.642-1, P = 0.002). The cut-off albumin level value was 37.5 g/L for sensitivity of 94.5% and specificity of 75%. In multivariate analysis, preoperative albumin and surgical resection margins were independent predictors of AE recurrence (HR = 0.099, P = 0.007 and HR = 0.182, P = 0.045 respectively). Conclusion: Low preoperative albumin level was associated with AE recurrence in the present cohort. Thus, preoperative albumin may be a useful biomarker to guide follow-up. Competing Interests: Conflict-of-interest statement: All the authors state that they have no conflict of interest related to this manuscript. |
| References: | Gastroenterol Res Pract. 2016;2016:8743187. (PMID: 26880899) J Am Coll Surg. 2011 May;212(5):804-12. (PMID: 21398158) Parasitol Int. 2006;55 Suppl:S283-7. (PMID: 16343985) Clin Microbiol Rev. 2004 Jan;17(1):107-35. (PMID: 14726458) Int J Clin Exp Pathol. 2015 Sep 01;8(9):11192-8. (PMID: 26617841) World J Surg. 2015 Nov;39(11):2641-51. (PMID: 26243563) World J Surg. 2015 Oct;39(10):2529-34. (PMID: 26067633) Dig Liver Dis. 2016 May;48(5):559-61. (PMID: 26818186) Gastroenterol Rep (Oxf). 2016 Jul 6;:null. (PMID: 27389416) Dig Liver Dis. 2015 Jun;47(6):488-94. (PMID: 25864774) Oncol Res Treat. 2014;37(4):192-7. (PMID: 24732643) Lancet. 2003 Oct 18;362(9392):1295-304. (PMID: 14575976) Acta Trop. 2010 Apr;114(1):1-16. (PMID: 19931502) Ann Surg. 2004 Aug;240(2):205-13. (PMID: 15273542) Hepatogastroenterology. 2015 Mar-Apr;62(138):393-8. (PMID: 25916070) Ann Surg. 2015 Nov;262(5):787-92; discussion 792-3. (PMID: 26583667) Ann Surg. 2016 Jun;263(6):1207-12. (PMID: 26135695) |
| فهرسة مساهمة: | Keywords: Albumin; Alveolar echinococcosis; Liver surgery; Predictive marker; Recurrence |
| المشرفين على المادة: | 0 (Biomarkers) 0 (Serum Albumin) |
| SCR Disease Name: | Alveolar echinococcosis |
| تواريخ الأحداث: | Date Created: 20170223 Date Completed: 20170807 Latest Revision: 20181202 |
| رمز التحديث: | 20240513 |
| مُعرف محوري في PubMed: | PMC5296201 |
| DOI: | 10.3748/wjg.v23.i5.853 |
| PMID: | 28223729 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2219-2840 |
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| DOI: | 10.3748/wjg.v23.i5.853 |