دورية أكاديمية
Multiple functional therapeutic effects of TnP: A small stable synthetic peptide derived from fish venom in a mouse model of multiple sclerosis.
العنوان: | Multiple functional therapeutic effects of TnP: A small stable synthetic peptide derived from fish venom in a mouse model of multiple sclerosis. |
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المؤلفون: | Komegae EN; Immunoregulation Unit, Special Laboratory of Applied Toxinology, Butantan Institute, São Paulo, Brazil., Souza TA; Immunoregulation Unit, Special Laboratory of Applied Toxinology, Butantan Institute, São Paulo, Brazil., Grund LZ; Immunoregulation Unit, Special Laboratory of Applied Toxinology, Butantan Institute, São Paulo, Brazil., Lima C; Immunoregulation Unit, Special Laboratory of Applied Toxinology, Butantan Institute, São Paulo, Brazil., Lopes-Ferreira M; Immunoregulation Unit, Special Laboratory of Applied Toxinology, Butantan Institute, São Paulo, Brazil. |
المصدر: | PloS one [PLoS One] 2017 Feb 24; Vol. 12 (2), pp. e0171796. Date of Electronic Publication: 2017 Feb 24 (Print Publication: 2017). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: San Francisco, CA : Public Library of Science |
مواضيع طبية MeSH: | Encephalomyelitis, Autoimmune, Experimental/*drug therapy , Fish Venoms/*chemistry , Immunologic Factors/*pharmacology , Peptides/*pharmacology , Spinal Cord/*drug effects , T-Lymphocytes, Regulatory/*drug effects, Amino Acid Sequence ; Animals ; Antigens, Differentiation/genetics ; Antigens, Differentiation/immunology ; Brazil ; Cuprizone ; Disease Models, Animal ; Encephalomyelitis, Autoimmune, Experimental/chemically induced ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Encephalomyelitis, Autoimmune, Experimental/pathology ; Female ; Gene Expression Regulation ; Immunologic Factors/isolation & purification ; Interferon-gamma/genetics ; Interferon-gamma/immunology ; Interleukin-10/genetics ; Interleukin-10/immunology ; Interleukin-17/genetics ; Interleukin-17/immunology ; Macrophages/drug effects ; Macrophages/immunology ; Macrophages/pathology ; Matrix Metalloproteinase 9/genetics ; Matrix Metalloproteinase 9/immunology ; Mice ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/immunology ; Multiple Sclerosis/pathology ; Peptides/isolation & purification ; Perciformes/metabolism ; Spinal Cord/immunology ; Spinal Cord/pathology ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/pathology ; Th1 Cells/drug effects ; Th1 Cells/immunology ; Th1 Cells/pathology ; Th17 Cells/drug effects ; Th17 Cells/immunology ; Th17 Cells/pathology |
مستخلص: | The pathological condition of multiple sclerosis (MS) relies on innate and adaptive immunity. New types of agents that beneficially modify the course of MS, stopping the progression and repairing the damage appear promising. Here, we studied TnP, a small stable synthetic peptide derived from fish venom in the control of inflammation and demyelination in experimental autoimmune encephalomyelitis as prophylactic treatment. TnP decreased the number of the perivascular infiltrates in spinal cord, and the activity of MMP-9 by F4/80+ macrophages were decreased after different regimen treatments. TnP reduces in the central nervous system the infiltration of IFN-γ-producing Th1 and IL-17A-producing Th17 cells. Also, treatment with therapeutic TnP promotes the emergence of functional Treg in the central nervous system entirely dependent on IL-10. Therapeutic TnP treatment accelerates the remyelination process in a cuprizone model of demyelination. These findings support the beneficial effects of TnP and provides a new therapeutic opportunity for the treatment of MS. |
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المشرفين على المادة: | 0 (Antigens, Differentiation) 0 (Fish Venoms) 0 (Immunologic Factors) 0 (Interleukin-17) 0 (Peptides) 0 (monocyte-macrophage differentiation antigen) 130068-27-8 (Interleukin-10) 5N16U7E0AO (Cuprizone) 82115-62-6 (Interferon-gamma) EC 3.4.24.35 (Matrix Metalloproteinase 9) |
تواريخ الأحداث: | Date Created: 20170225 Date Completed: 20170817 Latest Revision: 20190208 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC5325231 |
DOI: | 10.1371/journal.pone.0171796 |
PMID: | 28235052 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1932-6203 |
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DOI: | 10.1371/journal.pone.0171796 |