دورية أكاديمية
Antiparasitic activity of 1,3-dioxolanes containing tellurium in Trichomonas vaginalis.
| العنوان: | Antiparasitic activity of 1,3-dioxolanes containing tellurium in Trichomonas vaginalis. |
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| المؤلفون: | Sena-Lopes Â; Laboratório de Biotecnologia Infecto-parasitária, Centro de Desenvolvimento Tecnológico, Biotecnologia, UFPel, Pelotas, RS 96010-900, Brazil. Electronic address: angelasena@ymail.com., das Neves RN; Laboratório de Biotecnologia Infecto-parasitária, Centro de Desenvolvimento Tecnológico, Biotecnologia, UFPel, Pelotas, RS 96010-900, Brazil., Bezerra FSB; Laboratório de Biotecnologia Infecto-parasitária, Centro de Desenvolvimento Tecnológico, Biotecnologia, UFPel, Pelotas, RS 96010-900, Brazil., de Oliveira Silva MT; Laboratório de Biotecnologia Infecto-parasitária, Centro de Desenvolvimento Tecnológico, Biotecnologia, UFPel, Pelotas, RS 96010-900, Brazil., Nobre PC; LASOL-CCQFA, Universidade Federal de Pelotas-UFPel, P.O. Box 354, Pelotas, RS 96010-900, Brazil., Perin G; LASOL-CCQFA, Universidade Federal de Pelotas-UFPel, P.O. Box 354, Pelotas, RS 96010-900, Brazil., Alves D; LASOL-CCQFA, Universidade Federal de Pelotas-UFPel, P.O. Box 354, Pelotas, RS 96010-900, Brazil., Savegnago L; Laboratório de Neurobiotecnologia, Centro de Desenvolvimento Tecnológico, Biotecnologia, UFPel, Pelotas, RS 96010-900, Brazil., Begnini KR; Laboratório de Biotecnologia do Câncer, Centro de Desenvolvimento Tecnológico, Biotecnologia, UFPel, Pelotas, RS 96010-900, Brazil., Seixas FK; Laboratório de Biotecnologia do Câncer, Centro de Desenvolvimento Tecnológico, Biotecnologia, UFPel, Pelotas, RS 96010-900, Brazil., Collares T; Laboratório de Biotecnologia do Câncer, Centro de Desenvolvimento Tecnológico, Biotecnologia, UFPel, Pelotas, RS 96010-900, Brazil., Borsuk S; Laboratório de Biotecnologia Infecto-parasitária, Centro de Desenvolvimento Tecnológico, Biotecnologia, UFPel, Pelotas, RS 96010-900, Brazil. |
| المصدر: | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2017 May; Vol. 89, pp. 284-287. Date of Electronic Publication: 2017 Feb 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Paris : Editions Scientifiques Elsevier Original Publication: New York, N.Y. : Masson Pub. USA, Inc., c1982- |
| مواضيع طبية MeSH: | Antiparasitic Agents/*pharmacology , Dioxolanes/*pharmacology , Tellurium/*pharmacology , Trichomonas vaginalis/*drug effects, Animals ; CHO Cells ; Cell Line ; Cricetulus ; Parasitic Sensitivity Tests/methods ; Trichomonas Infections/drug therapy ; Trophozoites/drug effects |
| مستخلص: | The increased prevalence of metronidazole-resistant infections has resulted in a search for alternative drugs for the treatment of trichomoniasis. In the present study, we report the preparation and in vitro activity of three 1,3-dioxolanes that contain tellurium (PTeDOX 01, PTeDOX 02, and PTeDOX 03) against Trichomonas vaginalis. Six concentrations of these compounds were analyzed for in vitro activity against ATCC 30236 isolate of T. vaginalis. PTeDOX 01 reported a cytotoxic effect against 100% of T. vaginalis trophozoites at a final concentration of 90μM with an IC (Copyright © 2017 Elsevier Masson SAS. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Antiparasitic; Organic tellurium; Trichomonas vaginalis |
| المشرفين على المادة: | 0 (Antiparasitic Agents) 0 (Dioxolanes) NQA0O090ZJ (Tellurium) Y57RBG19JL (formal glycol) |
| تواريخ الأحداث: | Date Created: 20170226 Date Completed: 20180214 Latest Revision: 20180214 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.biopha.2017.01.173 |
| PMID: | 28236702 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1950-6007 |
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| DOI: | 10.1016/j.biopha.2017.01.173 |