دورية أكاديمية
[Correlation of Th17 Cells and IL-17 Level in Multiple Myeloma Patients with Pathogenesis of Multiple Myeloma].
| العنوان: | [Correlation of Th17 Cells and IL-17 Level in Multiple Myeloma Patients with Pathogenesis of Multiple Myeloma]. |
|---|---|
| المؤلفون: | DU CY; Department of Hematology, The Center Hospital of Nanyang, Nanyang 473001, Henan Province, China., Yang RY; Department of Hematology, The Center Hospital of Nanyang, Nanyang 473001, Henan Province, China. E-mail: doctor681@163.com., Li C; Department of Hematology, The Center Hospital of Nanyang, Nanyang 473001, Henan Province, China., Duan LJ; Department of Hematology, The Center Hospital of Nanyang, Nanyang 473001, Henan Province, China. |
| المصدر: | Zhongguo shi yan xue ye xue za zhi [Zhongguo Shi Yan Xue Ye Xue Za Zhi] 2017 Feb; Vol. 25 (1), pp. 147-150. |
| نوع المنشور: | Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Zhongguo shi yan xue za zhi she Country of Publication: China NLM ID: 101084424 Publication Model: Print Cited Medium: Print ISSN: 1009-2137 (Print) Linking ISSN: 10092137 NLM ISO Abbreviation: Zhongguo Shi Yan Xue Ye Xue Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Beijing : Zhongguo shi yan xue za zhi she, |
| مواضيع طبية MeSH: | Th17 Cells*, Interleukin-17/*analysis , Multiple Myeloma/*immunology, Flow Cytometry ; Humans ; Multiple Myeloma/drug therapy ; Multiple Myeloma/metabolism |
| مستخلص: | Objective: To explore the correlation of Th17 cell rate and IL-17 level with pathogenetis of multiple myeloma(MM). Methods: Forty-five cases of MM were enrolled in MM group, while 45 healthy volunteers were selected in control group. The rate of Th17 cells, levels of IL-17 and β2-microglobulin(β2-MG) in patients subgrouping according to ISS staging and treatment were detected by using flow cytometer and IL-17 assay kit. The correlation of Th17 cell rate and IL-17 level with MM was analyzed. Results: The rate of Th17 cells and level of IL-17 in MM group were higher than those in control group(P<0.05), the rate of Th17 cells and level of IL-17 in ISS III stage patients were higher than those in ISS I and II stage patients(P<0.05); the rate of Th17 cells and level of IL-17 in ISS I and ISS II stage patients were not significant difference (P>0.05); the rate of Th17 cells and level of IL-17 in firstly treated, retreated/refractory patients were significantly higher than those in patients with effective treatment(P<0.05), while the rate of Th17 cells and level of IL-17 between firstly treated patients and retreated/refractory patients were not significant difference (P>0.05). The Th17 rate and IL-17 level in MM patients positively correlated with β2-MG level (r=0.422, r=0.416, P<0.05). Conclusion: The obvious increase of Th17 rate, IL-17 and β2-MG levels closely relates with pathogenesis of MM. The Th17 rate and IL-17 level may be used as important evidence for evaluation of ISS stage and therapeutic efficacy of MM. |
| المشرفين على المادة: | 0 (Interleukin-17) |
| تواريخ الأحداث: | Date Created: 20170301 Date Completed: 20180711 Latest Revision: 20181202 |
| رمز التحديث: | 20240628 |
| DOI: | 10.7534/j.issn.1009-2137.2017.01.026 |
| PMID: | 28245392 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1009-2137 |
|---|---|
| DOI: | 10.7534/j.issn.1009-2137.2017.01.026 |