دورية أكاديمية
أعرض في EDS

Platelet-independent adhesion of calcium-loaded erythrocytes to von Willebrand factor.

التفاصيل البيبلوغرافية
العنوان: Platelet-independent adhesion of calcium-loaded erythrocytes to von Willebrand factor.
المؤلفون: Smeets MW; Department of Molecular Cell Biology, Sanquin-Academic Medical Center Landsteiner Laboratory, Amsterdam, The Netherlands., Bierings R; Department of Plasma Proteins, Sanquin-Academic Medical Center Landsteiner Laboratory, Amsterdam, The Netherlands., Meems H; Department of Plasma Proteins, Sanquin-Academic Medical Center Landsteiner Laboratory, Amsterdam, The Netherlands., Mul FP; Department of Molecular Cell Biology, Sanquin-Academic Medical Center Landsteiner Laboratory, Amsterdam, The Netherlands., Geerts D; Department of Pediatric Oncology/Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands., Vlaar AP; Department of Intensive Care Medicine, Amsterdam Medical Center, Amsterdam, The Netherlands., Voorberg J; Department of Plasma Proteins, Sanquin-Academic Medical Center Landsteiner Laboratory, Amsterdam, The Netherlands., Hordijk PL; Department of Molecular Cell Biology, Sanquin-Academic Medical Center Landsteiner Laboratory, Amsterdam, The Netherlands.; Department of Physiology, VU University Medical Center, Amsterdam, The Netherlands.
المصدر: PloS one [PLoS One] 2017 Mar 01; Vol. 12 (3), pp. e0173077. Date of Electronic Publication: 2017 Mar 01 (Print Publication: 2017).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Cell Adhesion*, Calcium/*metabolism , Erythrocytes/*metabolism , Thrombosis/*metabolism , von Willebrand Factor/*metabolism, ADAMTS13 Protein/metabolism ; Blood Platelets/physiology ; Cells, Cultured ; Erythrocytes/physiology ; Human Umbilical Vein Endothelial Cells/physiology ; Humans ; von Willebrand Factor/genetics
مستخلص: Adhesion of erythrocytes to endothelial cells lining the vascular wall can cause vaso-occlusive events that impair blood flow which in turn may result in ischemia and tissue damage. Adhesion of erythrocytes to vascular endothelial cells has been described in multiple hemolytic disorders, especially in sickle cell disease, but the adhesion of normal erythrocytes to endothelial cells has hardly been described. It was shown that calcium-loaded erythrocytes can adhere to endothelial cells. Because sickle erythrocyte adhesion to ECs can be enhanced by ultra-large von Willebrand factor multimers, we investigated whether calcium loading of erythrocytes could promote binding to endothelial cells via ultra-large von Willebrand factor multimers. We used (immunofluorescent) live-cell imaging of washed erythrocytes perfused over primary endothelial cells at venular flow rate. Using this approach, we show that calcium-loaded erythrocytes strongly adhere to histamine-stimulated primary human endothelial cells. This adhesion is mediated by ultra-large von Willebrand factor multimers. Von Willebrand factor knockdown or ADAMTS13 cleavage abolished the binding of erythrocytes to activated endothelial cells under flow. Platelet depletion did not interfere with erythrocyte binding to von Willebrand factor. Our results reveal platelet-independent adhesion of calcium-loaded erythrocytes to endothelium-derived von Willebrand factor. Erythrocyte adhesion to von Willebrand factor may be particularly relevant for venous thrombosis, which is characterized by the formation of erythrocyte-rich thrombi.
التعليقات: Erratum in: PLoS One. 2018 Mar 21;13(3):e0194958. (PMID: 29561911)
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المشرفين على المادة: 0 (von Willebrand Factor)
EC 3.4.24.87 (ADAMTS13 Protein)
EC 3.4.24.87 (ADAMTS13 protein, human)
SY7Q814VUP (Calcium)
تواريخ الأحداث: Date Created: 20170302 Date Completed: 20170817 Latest Revision: 20181113
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5332109
DOI: 10.1371/journal.pone.0173077
PMID: 28249049
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0173077