دورية أكاديمية
أعرض في EDS

Efficacy of intranasal dexmedetomidine versus oral midazolam for paediatric premedication.

التفاصيل البيبلوغرافية
العنوان: Efficacy of intranasal dexmedetomidine versus oral midazolam for paediatric premedication.
المؤلفون: Kumar L; Department of Anaesthesiology, Amrita Institute of Medical Sciences, Amrita University, Kochi, Kerala, India., Kumar A; Department of Anaesthesiology, Amrita Institute of Medical Sciences, Amrita University, Kochi, Kerala, India., Panikkaveetil R; Department of Anaesthesiology, Amrita Institute of Medical Sciences, Amrita University, Kochi, Kerala, India., Vasu BK; Department of Anaesthesiology, Amrita Institute of Medical Sciences, Amrita University, Kochi, Kerala, India., Rajan S; Department of Anaesthesiology, Amrita Institute of Medical Sciences, Amrita University, Kochi, Kerala, India., Nair SG; Department of Anaesthesiology, Amrita Institute of Medical Sciences, Amrita University, Kochi, Kerala, India.
المصدر: Indian journal of anaesthesia [Indian J Anaesth] 2017 Feb; Vol. 61 (2), pp. 125-130.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Medknow Country of Publication: India NLM ID: 0013243 Publication Model: Print Cited Medium: Print ISSN: 0019-5049 (Print) Linking ISSN: 00195049 NLM ISO Abbreviation: Indian J Anaesth Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: Mumbai : Medknow
Original Publication: Varanasi : A. Lal on behalf of The Indian Society Of Anaesthetists
مستخلص: Background and Aims: Premedication is an integral component of paediatric anaesthesia which, when optimal, allows comfortable separation of the child from the parent for induction and conduct of anaesthesia. Midazolam has been accepted as a safe and effective oral premedicant. Dexmedetomidine is a selective alpha-2 agonist with sedative and analgesic effects, which is effective through the transmucosal route. We compared the efficacy and safety of standard premedication with oral midazolam versus intranasal dexmedetomidine as premedication in children undergoing elective lower abdominal surgery.
Methods: This was a prospective randomised double-blinded trial comparing the effects of premedication with 0.5 mg/kg oral midazolam versus 1 μg/kg intranasal dexmedetomidine in children between 2 and 12 years undergoing abdominal surgery. Sedation scores at separation and induction were the primary outcome measures. Behaviour scores and haemodynamic changes were secondary outcomes. Student's t -test and Chi-square were used for analysis of the variables.
Results: Sedation scores were superior in Group B (dexmedetomidine) than Group A (midazolam) at separation and induction ( P < 0.001). The behaviour scores at separation, induction and wake up scores at extubation were similar between the two groups. The heart rate and blood pressure showed significant differences at 15, 30 and 45 min in Group B but did not require pharmacological intervention for correction.
Conclusion: Intranasal dexmedetomidine at a dose of 1 μg/kg produced superior sedation scores at separation and induction but normal behavioural scores in comparison to oral midazolam in paediatric patients.
Competing Interests: There are no conflicts of interest.
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فهرسة مساهمة: Keywords: Intranasal dexmedetomidine; oral midazolam; paediatric premedication
تواريخ الأحداث: Date Created: 20170303 Latest Revision: 20200930
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC5330068
DOI: 10.4103/0019-5049.199850
PMID: 28250480
قاعدة البيانات: MEDLINE
الوصف
تدمد:0019-5049
DOI:10.4103/0019-5049.199850