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The roles of K Ca , K ATP , and K V channels in regulating cutaneous vasodilation and sweating during exercise in the heat.

التفاصيل البيبلوغرافية
العنوان: The roles of K Ca , K ATP , and K V channels in regulating cutaneous vasodilation and sweating during exercise in the heat.
المؤلفون: Louie JC; Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada; and., Fujii N; Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada; and.; Institute of Health and Sports Sciences, University of Tsukuba, Tsukuba, Japan., Meade RD; Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada; and., McNeely BD; Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada; and., Kenny GP; Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada; and gkenny@uottawa.ca.
المصدر: American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2017 May 01; Vol. 312 (5), pp. R821-R827. Date of Electronic Publication: 2017 Mar 02.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901230 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1490 (Electronic) Linking ISSN: 03636119 NLM ISO Abbreviation: Am J Physiol Regul Integr Comp Physiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Bethesda, Md. : American Physiological Society
مواضيع طبية MeSH: Skin Physiological Phenomena*, Exercise/*physiology , Heat-Shock Response/*physiology , Potassium Channels/*metabolism , Sweating/*physiology , Vasodilation/*physiology, Blood Flow Velocity/physiology ; Humans ; KATP Channels/metabolism ; Male ; Potassium Channels, Calcium-Activated/metabolism ; Potassium Channels, Voltage-Gated/metabolism ; Regional Blood Flow/physiology ; Skin/blood supply ; Young Adult
مستخلص: We recently showed the varying roles of Ca 2+ -activated (K Ca ), ATP-sensitive (K ATP ), and voltage-gated (K V ) K + channels in regulating cholinergic cutaneous vasodilation and sweating in normothermic conditions. However, it is unclear whether the respective contributions of these K + channels remain intact during dynamic exercise in the heat. Eleven young (23 ± 4 yr) men completed a 30-min exercise bout at a fixed rate of metabolic heat production (400 W) followed by a 40-min recovery period in the heat (35°C, 20% relative humidity). Cutaneous vascular conductance (CVC) and local sweat rate were assessed at four forearm skin sites perfused via intradermal microdialysis with: 1 ) lactated Ringer solution (control); 2 ) 50 mM tetraethylammonium (nonspecific K Ca channel blocker); 3 ) 5 mM glybenclamide (selective K ATP channel blocker); or 4 ) 10 mM 4-aminopyridine (nonspecific K V channel blocker). Responses were compared at baseline and at 10-min intervals during and following exercise. K Ca channel inhibition resulted in greater CVC versus control at end exercise ( P = 0.04) and 10 and 20 min into recovery (both P < 0.01). K ATP channel blockade attenuated CVC compared with control during baseline ( P = 0.04), exercise (all P ≤ 0.04), and 10 min into recovery ( P = 0.02). No differences in CVC were observed with K V channel inhibition during baseline ( P = 0.15), exercise (all P ≥ 0.06), or recovery (all P ≥ 0.14). With the exception of K V channel inhibition augmenting sweating during baseline ( P = 0.04), responses were similar to control with all K + channel blockers during each time period (all P ≥ 0.07). We demonstrated that K Ca and K ATP channels contribute to the regulation of cutaneous vasodilation during rest and/or exercise and recovery in the heat.
(Copyright © 2017 the American Physiological Society.)
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فهرسة مساهمة: Keywords: KATP; KCa; KV; cutaneous vasodilation; exercise; heat loss; hyperpolarization; sweat
المشرفين على المادة: 0 (KATP Channels)
0 (Potassium Channels)
0 (Potassium Channels, Calcium-Activated)
0 (Potassium Channels, Voltage-Gated)
تواريخ الأحداث: Date Created: 20170304 Date Completed: 20170825 Latest Revision: 20200930
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC5451568
DOI: 10.1152/ajpregu.00507.2016
PMID: 28254750
قاعدة البيانات: MEDLINE
الوصف
تدمد:1522-1490
DOI:10.1152/ajpregu.00507.2016