دورية أكاديمية
Study of Age-Dependent Structural and Functional Changes of Mitochondria in Skeletal Muscles and Heart of Naked Mole Rats (Heterocephalus glaber).
| العنوان: | Study of Age-Dependent Structural and Functional Changes of Mitochondria in Skeletal Muscles and Heart of Naked Mole Rats (Heterocephalus glaber). |
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| المؤلفون: | Holtze S; Leibniz Institute for Zoo and Wildlife Research, Department of Reproduction Management, Berlin, 10315, Germany. holtze@izw-berlin.de., Eldarov CM, Vays VB, Vangeli IM, Vysokikh MY, Bakeeva LE, Skulachev VP, Hildebrandt TB |
| المصدر: | Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2016 Dec; Vol. 81 (12), pp. 1429-1437. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MAIK Nauka/Interperiodica Country of Publication: United States NLM ID: 0376536 Publication Model: Print Cited Medium: Internet ISSN: 1608-3040 (Electronic) Linking ISSN: 00062979 NLM ISO Abbreviation: Biochemistry (Mosc) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2007->: Moscow : MAIK Nauka/Interperiodica Original Publication: New York, Consultants Bureau [etc.] |
| مواضيع طبية MeSH: | Aging*, Mitochondria, Muscle/*ultrastructure , Muscle, Skeletal/*ultrastructure, Animals ; Female ; Male ; Mice, Inbred C57BL ; Mitochondria, Heart/metabolism ; Mitochondria, Heart/ultrastructure ; Mitochondria, Muscle/metabolism ; Mole Rats ; Oxygen Consumption ; Rats, Wistar |
| مستخلص: | Morphometric analysis of mitochondria in skeletal muscles and heart of 6- and 60-month-old naked mole rats (Heterocephalus glaber) revealed a significant age-dependent increase in the total area of mitochondrial cross-sections in studied muscle fibers. For 6- and 60-month-old animals, these values were 4.8 ± 0.4 and 12.7 ± 1.8%, respectively. This effect is mainly based on an increase in the number of mitochondria. In 6-month-old naked mole rats, there were 0.23 ± 0.02 mitochondrial cross-sections per µm 2 of muscle fiber, while in 60-month-old animals this value was 0.47 ± 0.03. The average area of a single mitochondrial cross-section also increased with age in skeletal muscles - from 0.21 ± 0.01 to 0.29 ± 0.03 µm 2 . Thus, naked mole rats show a drastic enlargement of the mitochondrial apparatus in skeletal muscles with age due to an increase in the number of mitochondria and their size. They possess a neotenic type of chondriome accompanied by specific features of mitochondrial functioning in the state of oxidative phosphorylation and a significant decrease in the level of matrix adenine nucleotides. |
| تواريخ الأحداث: | Date Created: 20170306 Date Completed: 20170314 Latest Revision: 20170314 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1134/S000629791612004X |
| PMID: | 28259120 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1608-3040 |
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| DOI: | 10.1134/S000629791612004X |