دورية أكاديمية
Predicting serious complications in patients with cancer and pulmonary embolism using decision tree modelling: the EPIPHANY Index.
| العنوان: | Predicting serious complications in patients with cancer and pulmonary embolism using decision tree modelling: the EPIPHANY Index. |
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| المؤلفون: | Carmona-Bayonas A; Department of Hematology and Medical Oncology, Hospital Universitario Morales Meseguer, Instituto Murciano de Investigación Biosanitaria (IMIB), Murcia, Spain., Jiménez-Fonseca P; Department of Medical Oncology, H. Universitario Central de Asturias, Oviedo, Spain., Font C; Department of Medical Oncology, H. Universitario Clinic, Barcelona, Spain., Fenoy F; Department of Physiology, Facultad de Medicina, Universidad de Murcia, Murcia, Spain., Otero R; Department of Pneumology, H. Universitario Virgen del Rocío, CIBER de Enfermedades Respiratorias, Seville, Spain., Beato C; Department of Medical Oncology, Hospital Nisa-Aljarafe, Seville, Spain., Plasencia JM; Department of Radiology, Hospital Universitario Morales Meseguer, Murcia, Spain., Biosca M; Department of Medical Oncology, H. Universitario Vall d' Hebron, Barcelona, Spain., Sánchez M; Department of Radiology, H. Universitario Clinic, Barcelona, Spain., Benegas M; Department of Radiology, H. Universitario Clinic, Barcelona, Spain., Calvo-Temprano D; Department of Radiology, H. Universitario Central de Asturias, Oviedo, Spain., Varona D; Department of Radiology, H. Universitario Vall D' Hebron, Barcelona, Spain., Faez L; Department of Medical Oncology, H. Universitario Central de Asturias, Oviedo, Spain., de la Haba I; Department of Internal Medicine, ICO Duran i Reynals, Barcelona, Spain., Antonio M; Department of Medical Oncology, ICO Duran i Reynals, Barcelona, Spain., Madridano O; Department of Internal Medicine, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, Spain., Solis MP; Department of Medical Oncology, H. Universitario Central de Asturias, Oviedo, Spain., Ramchandani A; Department of Medical Oncology, Hospital Universitario Insular de Gran Canaria, Las Palmas, Spain., Castañón E; Department of Medical Oncology, Clínica Universidad de Navarra, Pamplona, Spain., Marchena PJ; Department of Internal Medicine, Parc Sanitari Sant Joan of Déu, Esplugues de Llobregat, Barcelona, Spain., Martín M; Department of Internal Medicine, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, Spain., Ayala de la Peña F; Department of Hematology and Medical Oncology, Hospital Universitario Morales Meseguer, Instituto Murciano de Investigación Biosanitaria (IMIB), Murcia, Spain., Vicente V; Department of Hematology and Medical Oncology, Hospital Universitario Morales Meseguer, Instituto Murciano de Investigación Biosanitaria (IMIB), Murcia, Spain. |
| المصدر: | British journal of cancer [Br J Cancer] 2017 Apr 11; Vol. 116 (8), pp. 994-1001. Date of Electronic Publication: 2017 Mar 07. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2002- : London : Nature Publishing Group on behalf of Cancer Research UK Original Publication: London, Lewis. |
| مواضيع طبية MeSH: | Decision Support Techniques* , Decision Trees* , Severity of Illness Index*, Neoplasms/*complications , Pulmonary Embolism/*diagnosis , Risk Assessment/*methods, Area Under Curve ; Female ; Follow-Up Studies ; Health Status Indicators ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Prognosis ; Pulmonary Embolism/etiology ; Pulmonary Embolism/mortality ; Registries ; Survival Rate |
| مستخلص: | Background: Our objective was to develop a prognostic stratification tool that enables patients with cancer and pulmonary embolism (PE), whether incidental or symptomatic, to be classified according to the risk of serious complications within 15 days. Methods: The sample comprised cases from a national registry of pulmonary thromboembolism in patients with cancer (1075 patients from 14 Spanish centres). Diagnosis was incidental in 53.5% of the events in this registry. The Exhaustive CHAID analysis was applied with 10-fold cross-validation to predict development of serious complications following PE diagnosis. Results: About 208 patients (19.3%, 95% confidence interval (CI), 17.1-21.8%) developed a serious complication after PE diagnosis. The 15-day mortality rate was 10.1%, (95% CI, 8.4-12.1%). The decision tree detected six explanatory covariates: Hestia-like clinical decision rule (any risk criterion present vs none), Eastern Cooperative Group performance scale (ECOG-PS; <2 vs ⩾2), O Conclusions: We have developed and internally validated a prognostic index to predict serious complications with the potential to impact decision-making in patients with cancer and PE. |
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| تواريخ الأحداث: | Date Created: 20170308 Date Completed: 20170606 Latest Revision: 20181113 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC5396106 |
| DOI: | 10.1038/bjc.2017.48 |
| PMID: | 28267709 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1532-1827 |
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| DOI: | 10.1038/bjc.2017.48 |