دورية أكاديمية
Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.
العنوان: | Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease. |
---|---|
المؤلفون: | Pishesha N; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115., Bilate AM; Whitehead Institute for Biomedical Research, Cambridge, MA 02142., Wibowo MC; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142., Huang NJ; Whitehead Institute for Biomedical Research, Cambridge, MA 02142., Li Z; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115., Deshycka R; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142., Bousbaine D; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142., Li H; Whitehead Institute for Biomedical Research, Cambridge, MA 02142., Patterson HC; Whitehead Institute for Biomedical Research, Cambridge, MA 02142., Dougan SK; Whitehead Institute for Biomedical Research, Cambridge, MA 02142., Maruyama T; Whitehead Institute for Biomedical Research, Cambridge, MA 02142., Lodish HF; Whitehead Institute for Biomedical Research, Cambridge, MA 02142; lodish@wi.mit.edu hidde.ploegh@childrens.harvard.edu.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142., Ploegh HL; Whitehead Institute for Biomedical Research, Cambridge, MA 02142; lodish@wi.mit.edu hidde.ploegh@childrens.harvard.edu.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142. |
المصدر: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 Mar 21; Vol. 114 (12), pp. 3157-3162. Date of Electronic Publication: 2017 Mar 07. |
نوع المنشور: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Washington, DC : National Academy of Sciences |
مستخلص: | Current therapies for autoimmune diseases rely on traditional immunosuppressive medications that expose patients to an increased risk of opportunistic infections and other complications. Immunoregulatory interventions that act prophylactically or therapeutically to induce antigen-specific tolerance might overcome these obstacles. Here we use the transpeptidase sortase to covalently attach disease-associated autoantigens to genetically engineered and to unmodified red blood cells as a means of inducing antigen-specific tolerance. This approach blunts the contribution to immunity of major subsets of immune effector cells (B cells, CD4 + and CD8 + T cells) in an antigen-specific manner. Transfusion of red blood cells expressing self-antigen epitopes can alleviate and even prevent signs of disease in experimental autoimmune encephalomyelitis, as well as maintain normoglycemia in a mouse model of type 1 diabetes. |
التعليقات: | Comment in: Sci Transl Med. 2017 Mar 22;9(382):. (PMID: 28330859) Erratum in: Proc Natl Acad Sci U S A. 2017 Apr 25;114(17 ):E3583. Dhesycka, Rhogerry [corrected to Deshycka, Rhogerry]. (PMID: 28396403) |
References: | Ann N Y Acad Sci. 2007 Sep;1110:99-111. (PMID: 17911425) Transfusion. 2016 Apr;56(4):905-16. (PMID: 26843479) Eur J Microbiol Immunol (Bp). 2016 Jan 27;6(1):1-8. (PMID: 27141310) Vaccine. 2014 Sep 29;32(43):5681-9. (PMID: 25149432) Immunol Cell Biol. 1998 Feb;76(1):34-40. (PMID: 9553774) Sci Transl Med. 2015 May 27;7(289):289ra81. (PMID: 26019217) ACS Nano. 2014 Mar 25;8(3):2148-60. (PMID: 24559284) Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11399-404. (PMID: 21697512) Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):E60-8. (PMID: 23248266) Biotechnol Bioeng. 2012 Dec;109(12):2955-61. (PMID: 22729808) Gene Ther. 2003 May;10(10):844-53. (PMID: 12732870) Arthritis Res Ther. 2008;10(1):R11. (PMID: 18221522) Nat Rev Immunol. 2007 Sep;7(9):665-77. (PMID: 17690713) Nat Chem Biol. 2007 Nov;3(11):707-8. (PMID: 17891153) Blood. 2011 Nov 10;118(19):5071-9. (PMID: 21885599) Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10131-6. (PMID: 24982154) Int J Pharm. 2013 Feb 25;443(1-2):39-49. (PMID: 23305866) J Immunol. 2007 Feb 15;178(4):2212-20. (PMID: 17277126) Jikken Dobutsu. 1980 Jan;29(1):1-13. (PMID: 6995140) Sci Transl Med. 2013 Jun 5;5(188):188ra75. (PMID: 23740901) Nat Biotechnol. 2015 May;33(5):538-42. (PMID: 25798939) J Immunol. 2013 Nov 15;191(10):5278-90. (PMID: 24123688) J Neuroinflammation. 2012 Jun 22;9:139. (PMID: 22727044) Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3842-7. (PMID: 10097125) Sci Rep. 2015 Oct 29;5:15907. (PMID: 26511151) J Immunol. 2008 Sep 15;181(6):3750-4. (PMID: 18768826) Ann N Y Acad Sci. 2004 Dec;1029:211-24. (PMID: 15681760) ACS Chem Biol. 2015 Feb 20;10(2):460-5. (PMID: 25360987) J Clin Invest. 2007 Aug;117(8):2268-78. (PMID: 17657313) J Immunol. 2011 Sep 1;187(5):2405-17. (PMID: 21821796) Annu Rev Biomed Eng. 2016 Jul 11;18:181-205. (PMID: 26928211) J Exp Med. 2014 Feb 10;211(2):365-79. (PMID: 24493799) Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3031-6. (PMID: 8610163) Traffic. 2012 Jun;13(6):780-9. (PMID: 22348280) J Immunol. 1999 Mar 15;162(6):3336-41. (PMID: 10092787) J Immunol. 2013 Sep 15;191(6):2938-47. (PMID: 23945139) Annu Rev Immunol. 2014;32:579-608. (PMID: 24499272) Nature. 2005 Jun 2;435(7042):612-9. (PMID: 15931214) Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):444-8. (PMID: 8290546) Nat Rev Immunol. 2009 May;9(5):353-63. (PMID: 19365408) Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13739-44. (PMID: 22869725) Immunol Cell Biol. 1995 Feb;73(1):89-94. (PMID: 7768549) Eur J Immunol. 1994 Sep;24(9):2104-9. (PMID: 7522160) Nat Rev Immunol. 2015 Aug;15(8):486-99. (PMID: 26205583) Ann N Y Acad Sci. 2003 Nov;1005:109-18. (PMID: 14679045) J Exp Med. 2016 May 30;213(6):887-96. (PMID: 27185856) Blood. 2013 Apr 18;121(16):3246-53. (PMID: 23422750) Immunity. 2001 Jul;15(1):15-22. (PMID: 11485734) Blood. 2015 Apr 9;125(15):2418-27. (PMID: 25700434) Immunity. 2011 Oct 28;35(4):456-66. (PMID: 22035838) Nat Biotechnol. 2012 Dec;30(12):1217-24. (PMID: 23159881) PLoS One. 2012;7(11):e49994. (PMID: 23166807) Vaccine. 2010 Apr 9;28(17):2965-72. (PMID: 20188177) Sci Adv. 2015 Jul 17;1(6):e1500112. (PMID: 26601215) |
معلومات مُعتمدة: | K08 GM102718 United States GM NIGMS NIH HHS; P01 HL032262 United States HL NHLBI NIH HHS; R01 AI087879 United States AI NIAID NIH HHS; United States HHMI Howard Hughes Medical Institute |
فهرسة مساهمة: | Keywords: antigen-specific tolerance; autoimmune diseases; engineered red blood cells; sortase |
تواريخ الأحداث: | Date Created: 20170309 Date Completed: 20180423 Latest Revision: 20220718 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC5373388 |
DOI: | 10.1073/pnas.1701746114 |
PMID: | 28270614 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1091-6490 |
---|---|
DOI: | 10.1073/pnas.1701746114 |