دورية أكاديمية
أعرض في EDS

Changing trend in bacterial etiology and antibiotic resistance in sepsis of intramural neonates at a tertiary care hospital.

التفاصيل البيبلوغرافية
العنوان: Changing trend in bacterial etiology and antibiotic resistance in sepsis of intramural neonates at a tertiary care hospital.
المؤلفون: Roy MP; Department of Pediatrics, VMMC and Safdarjung Hospital, New Delhi, India., Bhatt M; Department of Pediatrics, VMMC and Safdarjung Hospital, New Delhi, India., Maurya V; Department of Microbiology, VMMC and Safdarjung Hospital, New Delhi, India., Arya S; Department of Pediatrics, VMMC and Safdarjung Hospital, New Delhi, India., Gaind R; Department of Microbiology, VMMC and Safdarjung Hospital, New Delhi, India., Chellani HK; Department of Pediatrics, VMMC and Safdarjung Hospital, New Delhi, India.
المصدر: Journal of postgraduate medicine [J Postgrad Med] 2017 Jul-Sep; Vol. 63 (3), pp. 162-168.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Medknow Publications Country of Publication: India NLM ID: 2985196R Publication Model: Print Cited Medium: Internet ISSN: 0972-2823 (Electronic) Linking ISSN: 00223859 NLM ISO Abbreviation: J Postgrad Med Subsets: MEDLINE
أسماء مطبوعة: Publication: Mumbai : Medknow Publications
Original Publication: Bombay, India.
مواضيع طبية MeSH: Intensive Care Units, Neonatal*, Anti-Bacterial Agents/*pharmacology , Bacteria/*drug effects , Bacteria/*isolation & purification , Sepsis/*drug therapy , Sepsis/*microbiology, Bacteria/classification ; Drug Resistance, Microbial ; Female ; Humans ; India/epidemiology ; Infant, Newborn ; Male ; Microbial Sensitivity Tests ; Retrospective Studies ; Sepsis/epidemiology ; Tertiary Care Centers
مستخلص: Background: Septicemia is an important cause of neonatal morbidity and mortality. However, organized data on causative organisms and their resistant pattern are scanty from developing countries. The changing trend in causative organisms and their antibiotic resistance is yet to be documented in India. The present study examines the trends in bacterial profile and antibiotic resistance of the organisms causing sepsis in hospitalized neonates.
Materials and Methods: A retrospective laboratory-based analysis of blood cultures obtained from Neonatal Intensive Care Unit of a tertiary care hospital in New Delhi was done for the period of 1999-2014, divided into five phases.
Results: A total of 4700 isolates were considered. Over time, Gram-negative organisms have replaced Gram-positives as frequent isolates. Initially, there was predominance of Klebsiella pneumoniae, then of Staphylococcus aureus which recently has been changed with coagulase negative-Staphylococcus and Acinetobacter. Growing resistance against the first and second line of drugs has been noted, including methicillin-resistant S. aureus and vancomycin-resistant Enterococcus.
Conclusion: The etiological profile of neonatal sepsis has changed tremendously in the past 15 years. High resistance against common drugs necessitates continued surveillance and review of empirical antibiotic policy for neonatal sepsis. These steps are important to effectively curtail the surge of further antibiotic resistance.
References: J Med Assoc Thai. 2009 Mar;92(3):413-9. (PMID: 19301737)
Indian J Pediatr. 1988 Nov-Dec;55(6):955-60. (PMID: 3235146)
J Commun Dis. 2005 Sep;37(3):227-32. (PMID: 17080707)
J Infect Dev Ctries. 2009 Nov 13;4(1):55-7. (PMID: 20130381)
Indian J Pediatr. 2011 Apr;78(4):413-7. (PMID: 21165715)
Pediatrics. 2005 Sep;116(3):595-602. (PMID: 16140698)
Lancet. 2005 Mar 26-Apr 1;365(9465):1147-52. (PMID: 15794969)
J Trop Pediatr. 2010 Apr;56(2):90-6. (PMID: 19608665)
N Engl J Med. 2002 Jul 25;347(4):240-7. (PMID: 12140299)
Am J Infect Control. 2008 Jun;36(5):309-32. (PMID: 18538699)
Indian J Pediatr. 2001 Aug;68(8):715-7. (PMID: 11563247)
Jpn J Infect Dis. 2009 Jan;62(1):46-50. (PMID: 19168958)
JAMA. 2004 Nov 17;292(19):2357-65. (PMID: 15547163)
Indian J Public Health. 2010 Oct-Dec;54(4):213-5. (PMID: 21372371)
Indian J Pediatr. 2014 Aug;81(8):785-90. (PMID: 24408399)
Lancet. 2005 Mar 26-Apr 1;365(9465):1175-88. (PMID: 15794973)
J Trop Pediatr. 2015 Feb;61(1):1-13. (PMID: 25604489)
East Mediterr Health J. 2000 Mar-May;6(2-3):483-6. (PMID: 11556040)
J Lab Physicians. 2010 Jul;2(2):85-8. (PMID: 21346903)
Indian J Med Res. 2013 Feb;137(2):363-9. (PMID: 23563381)
Pediatr Clin North Am. 2013 Apr;60(2):367-89. (PMID: 23481106)
Int J Infect Dis. 2009 Jul;13(4):499-505. (PMID: 19058989)
Ann Trop Paediatr. 2007 Mar;27(1):45-54. (PMID: 17469732)
المشرفين على المادة: 0 (Anti-Bacterial Agents)
تواريخ الأحداث: Date Created: 20170309 Date Completed: 20190902 Latest Revision: 20190902
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5525480
DOI: 10.4103/0022-3859.201425
PMID: 28272077
قاعدة البيانات: MEDLINE
الوصف
تدمد:0972-2823
DOI:10.4103/0022-3859.201425