دورية أكاديمية
The inhibitory receptor toll interleukin-1R 8 (TIR8/IL-1R8/SIGIRR) is downregulated in chronic lymphocytic leukemia.
| العنوان: | The inhibitory receptor toll interleukin-1R 8 (TIR8/IL-1R8/SIGIRR) is downregulated in chronic lymphocytic leukemia. |
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| المؤلفون: | Vilia MG; a Division of Experimental Oncology , IRCCS San Raffaele Scientific Institute , Milano , Italy., Fonte E; a Division of Experimental Oncology , IRCCS San Raffaele Scientific Institute , Milano , Italy., Veliz Rodriguez T; a Division of Experimental Oncology , IRCCS San Raffaele Scientific Institute , Milano , Italy., Tocchetti M; a Division of Experimental Oncology , IRCCS San Raffaele Scientific Institute , Milano , Italy., Ranghetti P; a Division of Experimental Oncology , IRCCS San Raffaele Scientific Institute , Milano , Italy., Scarfò L; a Division of Experimental Oncology , IRCCS San Raffaele Scientific Institute , Milano , Italy.; b Vita-Salute San Raffaele University , Milano , Italy., Papakonstantinou N; c Institute of Applied Biosciences, CERTH , Thessaloniki , Greece.; d Department of Immunology, Genetics and Pathology, Rudbeck Laboratory , Uppsala University , Uppsala , Sweden., Ntoufa S; c Institute of Applied Biosciences, CERTH , Thessaloniki , Greece.; d Department of Immunology, Genetics and Pathology, Rudbeck Laboratory , Uppsala University , Uppsala , Sweden., Stamatopoulos K; c Institute of Applied Biosciences, CERTH , Thessaloniki , Greece.; d Department of Immunology, Genetics and Pathology, Rudbeck Laboratory , Uppsala University , Uppsala , Sweden., Ghia P; a Division of Experimental Oncology , IRCCS San Raffaele Scientific Institute , Milano , Italy.; b Vita-Salute San Raffaele University , Milano , Italy., Muzio M; a Division of Experimental Oncology , IRCCS San Raffaele Scientific Institute , Milano , Italy. |
| المصدر: | Leukemia & lymphoma [Leuk Lymphoma] 2017 Oct; Vol. 58 (10), pp. 2419-2425. Date of Electronic Publication: 2017 Feb 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 9007422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1029-2403 (Electronic) Linking ISSN: 10268022 NLM ISO Abbreviation: Leuk Lymphoma Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: [Philadelphia, PA] : Taylor & Francis Original Publication: Chur ; New York : London, UK : Harwood Academic Publishers ; Distributed by STBS, 1989- |
| مواضيع طبية MeSH: | Antimetabolites, Antineoplastic*/administration & dosage , Azacitidine*/administration & dosage , Leukemia, Lymphocytic, Chronic, B-Cell*/drug therapy , Leukemia, Lymphocytic, Chronic, B-Cell*/genetics , Leukemia, Lymphocytic, Chronic, B-Cell*/metabolism , Receptors, Interleukin-1*/metabolism, Animals ; DNA Methylation ; Disease Models, Animal ; Humans ; Inflammation ; Mice |
| مستخلص: | Toll interleukin-1 receptor 8 (also known as TIR8, SIGIRR, or IL1R8) is a transmembrane receptor that inhibits inflammation. Accordingly, genetic inactivation of this protein exacerbates chronic inflammation and inflammation-associated tumors in mice. In particular, lack of TIR8 triggers leukemia progression in a mouse model of chronic lymphocytic leukemia (CLL), supporting its role as a novel tumor restrainer. The aim of this study was to measure the amount of TIR8 mRNA and protein in CLL cells, and to analyze its regulation of expression. Circulating leukemic cells expressed lower levels of TIR8 compared to normal B-lymphocytes. Treatment of CLL cells with Azacytidine restored higher levels of TIR8 suggesting that DNA methylation may be involved in modulating TIR8 expression, with implications for novel therapeutic strategies. |
| فهرسة مساهمة: | Keywords: Azacytidine; SIGIRR; TIR8; Toll like receptors; chronic lymphocytic leukemia; toll interleukin-1 receptor 8 |
| المشرفين على المادة: | 0 (Antimetabolites, Antineoplastic) 0 (Receptors, Interleukin-1) 0 (SIGIRR protein, human) 0 (SIGIRR protein, mouse) M801H13NRU (Azacitidine) |
| تواريخ الأحداث: | Date Created: 20170311 Date Completed: 20190426 Latest Revision: 20190426 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1080/10428194.2017.1295142 |
| PMID: | 28278705 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1029-2403 |
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| DOI: | 10.1080/10428194.2017.1295142 |