دورية أكاديمية
Expression of human nerve growth factor receptor on cells derived from all three germ layers.
| العنوان: | Expression of human nerve growth factor receptor on cells derived from all three germ layers. |
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| المؤلفون: | Thomson TM; Laboratory of Human Cancer Immunology, Sloan-Kettering Institute, New York, New York 10021., Rettig WJ, Chesa PG, Green SH, Mena AC, Old LJ |
| المصدر: | Experimental cell research [Exp Cell Res] 1988 Feb; Vol. 174 (2), pp. 533-9. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 0373226 Publication Model: Print Cited Medium: Print ISSN: 0014-4827 (Print) Linking ISSN: 00144827 NLM ISO Abbreviation: Exp Cell Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Orlando Fl : Academic Press Original Publication: New York, Academic Press. |
| مواضيع طبية MeSH: | Nerve Growth Factors/*metabolism , Neurons/*analysis , Receptors, Cell Surface/*analysis, Cell Differentiation ; Cell Survival ; Cells, Cultured ; Flow Cytometry ; Fluorescent Antibody Technique ; Hemadsorption ; Humans ; Immunohistochemistry ; Neurons/cytology ; Receptors, Cell Surface/immunology ; Receptors, Nerve Growth Factor ; Tumor Cells, Cultured |
| مستخلص: | Nerve growth factor (NGF) is a protein which promotes the survival and differentiation of neuronal cells in vitro and plays an important role in neuronal development. In this study, we have examined the expression of the receptor for NGF (NGFR) in human neuronal and nonneuronal cells, both in tissue culture and in vivo. In addition to cell lines derived from neuroblastoma, astrocytoma, and melanoma, all of which share a common neuroectodermal origin, NGFR was detected in a number of cultured cells of mesenchymal, epithelial, and hematopoietic derivation. Immunohistochemical analysis showed that NGFR is expressed in several nonneural human tissues, and the cell types in which NGFR was found include derivatives from all three germ layers. Thus, our findings demonstrate that NGFR is much more widely expressed in human cells and tissues than was previously thought. |
| معلومات مُعتمدة: | CA-08784 United States CA NCI NIH HHS; CA-25803 United States CA NCI NIH HHS; NS-16036 United States NS NINDS NIH HHS |
| المشرفين على المادة: | 0 (Nerve Growth Factors) 0 (Receptors, Cell Surface) 0 (Receptors, Nerve Growth Factor) |
| تواريخ الأحداث: | Date Created: 19880201 Date Completed: 19880323 Latest Revision: 20190707 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/0014-4827(88)90323-0 |
| PMID: | 2828087 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0014-4827 |
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| DOI: | 10.1016/0014-4827(88)90323-0 |