دورية أكاديمية
أعرض في EDS

The Antidiabetic Activity of Nigella sativa and Propolis on Streptozotocin-Induced Diabetes and Diabetic Nephropathy in Male Rats.

التفاصيل البيبلوغرافية
العنوان: The Antidiabetic Activity of Nigella sativa and Propolis on Streptozotocin-Induced Diabetes and Diabetic Nephropathy in Male Rats.
المؤلفون: El Rabey HA; Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia; Bioinformatics Department, Genetic Engineering and Biotechnology Institute, University of Sadat City, Sadat City, Monufia, Egypt., Al-Seeni MN; Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia., Bakhashwain AS; Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
المصدر: Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2017; Vol. 2017, pp. 5439645. Date of Electronic Publication: 2017 Feb 16.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub Country of Publication: United States NLM ID: 101215021 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1741-427X (Print) Linking ISSN: 1741427X NLM ISO Abbreviation: Evid Based Complement Alternat Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2011- : New York, NY : Hindawi Pub.
Original Publication: Oxford, UK : Oxford University Press, c2004-
مستخلص: This study was conducted to compare the ameliorative effect of Nigella sativa and propolis methanol extract on streptozotocin -induced diabetic male rats and treating diabetic nephropathy. Forty male Albino rats were divided into four groups; the first group was the negative control fed standard diet. The other 30 rats were injected with streptozotocin to induce diabetes by a single intravenous injection and then divided equally into three groups; the second group was the positive diabetic control; the third and the fourth groups were treated orally with 20% w/w Nigella sativa seeds methanol extract and propolis methanol extract (20% w/w), respectively. The rats of the second group showed increased glucose levels and lipid peroxide accompanied with reduction in superoxide dismutase, catalase, and glutathione-S-transferase enzyme activities compared with the negative control. Carboxymethyl lysine, interleukin-6, and immunoglobulins were also increased as a result of diabetes. Kidney function parameters were also elevated, while potassium and sodium levels were decreased. Moreover, tissues of kidney and pancreas showed severe histopathological changes. Treating the diabetic rats with Nigella sativa and propolis methanol extract in the third and fourth groups, respectively, ameliorated all altered biochemical and pathological examinations approaching the negative control. Propolis was more effective than Nigella sativa .
Competing Interests: The authors of this paper declare that they have no competing interests.
References: Diabetologia. 2004 Aug;47(8):1385-95. (PMID: 15309289)
Molecules. 2015 May 26;20(6):9560-74. (PMID: 26016547)
Cardiovasc Diabetol. 2013 Oct 10;12:146. (PMID: 24112518)
Iran J Pharm Res. 2015 Winter;14(1):131-40. (PMID: 25561919)
Analyst. 1972 Feb;97(151):142-5. (PMID: 5037807)
Cardiovasc Diabetol. 2013 Oct 17;12:149. (PMID: 24134530)
Res Vet Sci. 2004 Oct;77(2):123-9. (PMID: 15196902)
Biomed Res Int. 2015;2015:381040. (PMID: 25629046)
World J Clin Cases. 2014 Oct 16;2(10):488-96. (PMID: 25325058)
Chin J Physiol. 2011 Apr 30;54(2):79-86. (PMID: 21789888)
Clin Exp Immunol. 2008 Jan;151(1):42-50. (PMID: 18005364)
Pharmacol Res Commun. 1988 Apr;20(4):323-8. (PMID: 3387460)
Am J Chin Med. 2011;39(6):1075-91. (PMID: 22083982)
Med Sci Monit. 2007 Dec;13(12):BR286-92. (PMID: 18049430)
J Immunol. 1965 Jan;94:84-90. (PMID: 14253527)
Eur J Pharmacol. 2008 Jun 10;587(1-3):296-301. (PMID: 18474366)
Food Chem Toxicol. 2010 Jan;48(1):76-82. (PMID: 19766694)
J Clin Pathol. 1960 Mar;13:156-9. (PMID: 13821779)
Am J Clin Pathol. 1958 Jan;29(1):86-9. (PMID: 13508608)
Phytother Res. 2010 Oct;24(10):1554-61. (PMID: 20878710)
PLoS One. 2013 Jun 12;8(6):e66611. (PMID: 23776688)
Evid Based Complement Alternat Med. 2013;2013:983923. (PMID: 23365614)
Evid Based Complement Alternat Med. 2013;2013:215391. (PMID: 23861699)
J Diabetes. 2010 Dec;2(4):256-66. (PMID: 20923501)
Pharm Res. 1993 Jul;10(7):1093-5. (PMID: 8378254)
BMC Immunol. 2015 Sep 15;16:54. (PMID: 26370805)
Biochem Biophys Res Commun. 1972 Jan 31;46(2):849-54. (PMID: 4400444)
J Mol Med (Berl). 1996 Jan;74(1):1-12. (PMID: 8834766)
Anaerobe. 2010 Dec;16(6):566-71. (PMID: 20934525)
Endocr Relat Cancer. 2009 Dec;16(4):1103-23. (PMID: 19620249)
Physiol Res. 2001;50(6):537-46. (PMID: 11829314)
Korean J Physiol Pharmacol. 2014 Feb;18(1):1-14. (PMID: 24634591)
Pak J Pharm Sci. 2009 Apr;22(2):205-10. (PMID: 19339234)
Anal Biochem. 1979 Jun;95(2):351-8. (PMID: 36810)
Biol Trace Elem Res. 2011 Dec;144(1-3):463-8. (PMID: 21818670)
BMC Complement Altern Med. 2014 Jul 16;14:243. (PMID: 25026962)
Evid Based Complement Alternat Med. 2012;2012:580104. (PMID: 22991571)
Clin Chem. 1980 Feb;26(2):227-31. (PMID: 7353268)
J Diabetes Metab Disord. 2013 Dec 23;12(1):60. (PMID: 24364898)
Science. 1984 Jan 13;223(4632):175-8. (PMID: 6318318)
J Mol Histol. 2009 Apr;40(2):107-15. (PMID: 19484499)
Phytother Res. 2010 Jan;24 Suppl 1:S20-8. (PMID: 19472427)
Clin Chim Acta. 1972 Mar;37:193-7. (PMID: 5022083)
J Biol Chem. 1974 Nov 25;249(22):7130-9. (PMID: 4436300)
Tohoku J Exp Med. 2003 Dec;201(4):213-9. (PMID: 14690013)
Methods Enzymol. 1984;105:121-6. (PMID: 6727660)
Indian J Clin Biochem. 2014 Apr;29(2):221-6. (PMID: 24757306)
تواريخ الأحداث: Date Created: 20170317 Latest Revision: 20231104
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC5337387
DOI: 10.1155/2017/5439645
PMID: 28298934
قاعدة البيانات: MEDLINE
الوصف
تدمد:1741-427X
DOI:10.1155/2017/5439645