دورية أكاديمية
The Gut Microbiome, Energy Homeostasis, and Implications for Hypertension.
العنوان: | The Gut Microbiome, Energy Homeostasis, and Implications for Hypertension. |
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المؤلفون: | Riedl RA; Department of Pharmacology, University of Iowa, 51 Newton Rd., 2-307 BSB, Iowa City, IA, 52242, USA., Atkinson SN; Department of Informatics, subtract Bioinformatics, University of Iowa, Iowa City, IA, USA.; Department of Microbiology & Immunology, Medical College of Wisconsin, BSB - 2nd Floor - Room 230, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA., Burnett CML; Department of Internal Medicine, University of Iowa, Iowa City, IA, USA., Grobe JL; Department of Pharmacology, University of Iowa, 51 Newton Rd., 2-307 BSB, Iowa City, IA, 52242, USA. justin-grobe@uiowa.edu.; Iowa Microbiology Microbiome Initiative, University of Iowa, Iowa City, IA, USA. justin-grobe@uiowa.edu.; Obesity Research & Education Initiative, University of Iowa, Iowa City, IA, USA. justin-grobe@uiowa.edu.; Center for Hypertension Research, University of Iowa, Iowa City, IA, USA. justin-grobe@uiowa.edu.; Fraternal Order of Eagles' Diabetes Research Center, University of Iowa, Iowa City, IA, USA. justin-grobe@uiowa.edu., Kirby JR; Department of Microbiology, University of Iowa, Iowa City, IA, USA. jkirby@mcw.edu.; Iowa Microbiology Microbiome Initiative, University of Iowa, Iowa City, IA, USA. jkirby@mcw.edu.; Obesity Research & Education Initiative, University of Iowa, Iowa City, IA, USA. jkirby@mcw.edu.; Fraternal Order of Eagles' Diabetes Research Center, University of Iowa, Iowa City, IA, USA. jkirby@mcw.edu.; Department of Microbiology & Immunology, Medical College of Wisconsin, BSB - 2nd Floor - Room 230, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA. jkirby@mcw.edu. |
المصدر: | Current hypertension reports [Curr Hypertens Rep] 2017 Apr; Vol. 19 (4), pp. 27. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Current Science, Inc Country of Publication: United States NLM ID: 100888982 Publication Model: Print Cited Medium: Internet ISSN: 1534-3111 (Electronic) Linking ISSN: 15226417 NLM ISO Abbreviation: Curr Hypertens Rep Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Philadelphia, PA : Current Science, Inc., c1999- |
مواضيع طبية MeSH: | Gastrointestinal Microbiome* , Homeostasis* , Hypertension*, Animals ; Cardiovascular Diseases ; Gastrointestinal Tract ; Humans ; Obesity |
مستخلص: | Purpose of Review: The influence of gut bacteria upon host physiology is increasingly recognized, but mechanistic links are lacking. Diseases of energetic imbalance such as obesity and diabetes represent major risk factors for cardiovascular diseases such as hypertension. Thus, here, we review current mechanistic contributions of the gut microbiota to host energetics. Recent Findings: Gut bacteria generate a multitude of small molecules which can signal to host tissues within and beyond the gastrointestinal tract to influence host physiology, and gut bacteria can also influence host digestive efficiency by altering the bioavailability of polysaccharides, yet the quantitative energetic effects of these processes remain unclear. Recently, our team has demonstrated that gut bacteria constitute a major anaerobic thermogenic biomass, which can quantitatively account for obesity. Quantitative understanding of the mechanisms by which gut bacteria influence energy homeostasis may ultimately inform the relationship between gut bacteria and cardiovascular dysfunction. |
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معلومات مُعتمدة: | R01 HL134850 United States HL NHLBI NIH HHS; T35 HL007485 United States HL NHLBI NIH HHS; R00 HL098276 United States HL NHLBI NIH HHS; P01 HL084207 United States HL NHLBI NIH HHS; K99 HL098276 United States HL NHLBI NIH HHS; R01 AI108255 United States AI NIAID NIH HHS |
فهرسة مساهمة: | Keywords: Bacteria; Energetics; Energy; Metabolism; Microbiome; Microbiota |
تواريخ الأحداث: | Date Created: 20170320 Date Completed: 20180313 Latest Revision: 20190610 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC5773096 |
DOI: | 10.1007/s11906-017-0721-6 |
PMID: | 28316052 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1534-3111 |
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DOI: | 10.1007/s11906-017-0721-6 |