دورية أكاديمية
Genome-wide analysis of LPS-induced inflammatory response in the rat ventral hippocampus: Modulatory activity of the antidepressant agomelatine.
| العنوان: | Genome-wide analysis of LPS-induced inflammatory response in the rat ventral hippocampus: Modulatory activity of the antidepressant agomelatine. |
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| المؤلفون: | Rossetti AC; a Department of Pharmacological and Biomolecular Sciences , University of Milan , Milan , Italy., Paladini MS; b Department of Medical Biotechnology and Translational Medicine , University of Milan , Milan , Italy., Racagni G; a Department of Pharmacological and Biomolecular Sciences , University of Milan , Milan , Italy., Riva MA; a Department of Pharmacological and Biomolecular Sciences , University of Milan , Milan , Italy., Cattaneo A; c Biological Psychiatry Unit , IRCCS Centro San Giovanni di Dio - Fatebenefratelli , Brescia , Italy.; d Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience , King's College London , London , UK., Molteni R; b Department of Medical Biotechnology and Translational Medicine , University of Milan , Milan , Italy. |
| المصدر: | The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry [World J Biol Psychiatry] 2018 Aug; Vol. 19 (5), pp. 390-401. Date of Electronic Publication: 2017 Mar 24. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 101120023 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1814-1412 (Electronic) Linking ISSN: 15622975 NLM ISO Abbreviation: World J Biol Psychiatry Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Glasgow : WFSBP, 2000- |
| مواضيع طبية MeSH: | Acetamides/*pharmacology , Antidepressive Agents/*pharmacology , Hippocampus/*drug effects , Hippocampus/*immunology , Inflammation/*prevention & control , Transcription, Genetic/*drug effects , Transcription, Genetic/*immunology, Acetamides/administration & dosage ; Animals ; Antidepressive Agents/administration & dosage ; Disease Models, Animal ; Genome ; Inflammation/chemically induced ; Lipopolysaccharides/pharmacology ; Male ; Microarray Analysis ; Rats ; Rats, Sprague-Dawley |
| مستخلص: | Objectives: Several studies reported that antidepressant drugs have immune-regulatory effects by acting on specific inflammatory mediators. However, considering the highly complex nature of the inflammatory response, we have adopted an unbiased genome-wide strategy to investigate the immune-regulatory activity of the antidepressant agomelatine in modulating the response to an acute inflammatory challenge. Methods: Microarray analysis was used to identify genes modulated in the ventral hippocampus of adult rats chronically treated with agomelatine (40 mg/kg, os) before being challenged with a single injection of lipopolysaccharide (LPS; 250 μg/kg, i.p.). Results: The administration of LPS induced the transcription of 284 genes mainly associated with pathways related to the immune/inflammatory system. Agomelatine modulated pathways not only connected to its antidepressant activity, but was also able to prevent the activation of genes induced by LPS. Further comparisons between gene lists of the diverse experimental groups led to the identification of a few transcripts modulated by LPS on which agomelatine has the larger effect of normalisation. Among them, we found the pro-inflammatory cytokine Il-1β and, interestingly, the metabotropic glutamatergic transporter Grm2. Conclusions: These results are useful to better characterise the association between depression and inflammation, revealing new potential targets for pharmacological intervention for depression associated to inflammation. |
| فهرسة مساهمة: | Keywords: Microarray; agomelatine; antidepressant; lipopolysaccharide; neuroinflammation |
| المشرفين على المادة: | 0 (Acetamides) 0 (Antidepressive Agents) 0 (Lipopolysaccharides) 137R1N49AD (agomelatine) |
| تواريخ الأحداث: | Date Created: 20170325 Date Completed: 20181017 Latest Revision: 20220328 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1080/15622975.2017.1298839 |
| PMID: | 28337940 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1814-1412 |
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| DOI: | 10.1080/15622975.2017.1298839 |